Optimal deposition: the deciding factor Advanced technology: optimal effect multisonic LS Convincing technology: the ideal answer Inhaling with ultrasonics The success of therapy is dependent on delivery of the drug to the target site. The aerosol generated by multisonic nebulizers comprises very fine droplets which can pass through the alveoli. Clinical studies have shown that inhalation with multisonic nebulizers achieves a deposition of approx. 75% of the inhaled active ingredient in the respiratory tract. The loss of active ingredient is correspondingly low. Drug Ultrasonicwaves Coupling medium water Oscillator The ultrasonic waves from the oscillator continuously generate a very fine aerosol of the inhalation solution. This then penetrates the lungs down to the alveoli. Comparison of deposition Ultrasonic nebulizer – Jet nebulizer Frequency: 2.4 MHz MMAD: 3.5 µm Droplet size: 60% between 1 and 5 µ m Nebulizer performance: 0.2 - 1 ml per minute with Control‘Dose® and up to 3 ml per minute without Control‘Dose ® Fill volume: 2-8 ml with Control‘Dose ® 8-30 ml without Control‘Dose ® Noise level: 0 dB for LS 230 and LS 260 40 dB for LS 290 multisonic LS, the new generation of ultrasonic nebulizers which can be adapted to the needs of the individual Aerosol exit The individually-adaptable accessory sets are flexible in use (see Table) and the Control‘Dose® system ensures uniform atomization and optimal usage of the active ingredient. Measured with sodium chloride * Measurment by Dr. J. Zàhlava, University-Clinic Plzen, 23.10.1995 **Extract from Respiratory Medicine (1993) 87,461-465 Mixing chamber Control‘Dose Aerosol generation Drug Distributor: An optional convenient shoulder bag is available for transporting the unit and accessories. Mixing chamber Aerosol generation Drug SYSTAM Villeneuve sur Lot FRANCE Flores medical GmbH Hi-Tech Inalation Producer: Schill Medizintechnik Auwiesen 12 07330 Auwiesen 12 Probstzella D-07330 Probstzella GERMANY +49 36 735 463-0 Phone Fax +49 36 735 T +49 36735 463 0463-44 http://www.multisonic.de F +49e-mail: [email protected] 36735 463 44 [email protected] www.multisonic.de Kommunikationsbüro Ulm 0302/020/2764 Technical and optical operation reserve, Printed in Germany. The Control‘Dose -system ensures uniform nebulization and optimal usage of the active ingredient with a drug volume of 2-8 ml.

Inhalation made easier and more rapid: multisonic LS More and more people depend to varying degrees on inhaling drugs. The multisonic LS is an ideal means of achieving drug delivery. Its essential qualities are: Very rapid to use Thanks to the high nebulizer performance, only 5-10 minutes per sitting Effective The particles are 60% <5µm and therefore easily able to penetrate the alveoli Controlled use The patient Control‘Dose® system ensures uniform nebulizing and optimal usage of the active ingredient Power adaptable individually from 0.2 to 3 ml per minute nebulizer performance Silent in operation...