Biomark HD Amplify your productivity Biomark™ HD is an automated, high-performance PCR system that uses microfluidics technology to process samples at nanoliter-scale volumes for gene expression, genotyping, sample identification, copy number variation analysis and digital PCR. Ideal for labs performing PCR on hundreds to thousands of samples, the Biomark HD provides significant cost and time advantages over alternate technologies. And with a wide range of integrated fluidic circuit (IFC) formats available, scaling from mid- to high throughput on a single system is easily achievable. Efficient—Reduce costs with nanoliter-scale reaction volumes and walkaway automation. Fast—Analyze 96 samples with up to 96 markers in as little as four hours. Flexible—Perform gene expression, genotyping, sample identification, CNV analysis and digital PCR, all on a single system. A. Multiple applications on a single system GENE EXPRESSION Gene SAMPLE IDENTIFICATION Sample COPY NUMBER VARIATION Copy number Scalable—Easily scale from 144 to 9,216 reactions per run without changing technologies. identification variation B. Efficient assay workflow Select panel. Prepare samples Transfer to and assays. IFC. Figure 1. The Biomark HD advantage. (A) Easily perform multiple different applications on a single system using microfluidics technology. (B) Efficiently run up to 96 samples at a time using the automated Juno™ IFC controller and Biomark HD systems. Other IFC loaders are also a

Assay flexibility Biomark HD workflows are compatible with TaqMan® Assays and reagents as well as a number of other commercial assays, including Fluidigm SNP Type™ for genotyping and Delta Gene™ for gene expression. Easily move your existing panels to the Biomark HD to achieve immediate cost efficiencies or take advantage of commercially available panels including the Advanta™ Sample ID Genotyping Panel and Advanta IO Gene Expression Assay. Supported TaqMan, TaqMan TaqMan, TaqMan, TaqMan, TaqMan, chemistries SNP Type, SNP Type, SNP Type, SNP Type SNP Type, Delta Gene Delta Gene Delta Gene Delta...