PRODUCT DATASHEET PLGA MICROPARTICLE PRODUCTION STATION Standard Pack, P/N: 1DPPL01 Automation Pack, P/N: 1DPPL02 Full Pack, P/N: 1DPPL03 The Fluigent PLGA particle station is a robust and a high-quality system for producing monodispersed PLGA particles with flexibility to rapidly change particle sizes and production rates without interrupting production. Its performance results from the combination of Fluigent’s high precision LineUPTM microfluidic pumps and the RayDrop, a breakthrough technology for high-quality particle production device.

I description When PLGA is used as active pharmaceutical ingredient (API) carrier, the size of the particle is critical as it affects drug release characteristics. It is then essential to produce highly monodispersed particle for drug release reproducibility. The most common production process of PLGA particles is solvent based and can involve hazardous solutions. Ethyl acetate has been referenced as a less hazardous solvent than other conventional ones (dichloromethane for instance). Specifically designed for ethyl acetate solvent-based particle formation, it shows highly reproducible results...

PRODUCT DATASHEET DETAILED CONTENTS Standard Pack P/N: 1DPPL01 Content 2 * Flow EZTM (2000 mbar) 1 * Link 2 * FLOW UNIT (M and L) 3 * P-CAP (2 * 15 mL and 1 * 50 mL) 1 * RayDrop 1 * Support RayDrop A-i-O Software Standard connector and tubing kit Flow EZTM supply kit Figure 1: PLGA microparticle production station, standard pack content Set-up overview Figure 2: PLGA microparticle production station, standard pack set-up

PRODUCT DATASHEET Automation Pack P/N: 1DPPL02 Content 2 * Flow EZTM (2000 mbar) 1 * Link 2 * FLOW UNIT (M and L) 3 * P-CAP (2 * 15 mL and 1 * 50 mL) 2 * 2-SWITCHTM 1 * Switchboard 1 * RayDrop 1 * Support RayDrop A-i-O Software MAT Software Automation connector and tubing kit Flow EZTM supply kit Figure 3: PLGA microparticle production station, automation pack content Set-up overview Figure 4: PLGA microparticle production station, automation pack set-up

PRODUCT DATASHEET Full Pack P/N: 1DPPL03 Content 2 * Flow EZTM (2000 mbar) 1 * Link 2 * FLOW UNIT (M and L) 3 * P-CAP (2 * 15 mL and 1 * 50 mL) 2 * 2-SWITCHTM 1 * Switchboard 1 * RayDrop 1 * Support RayDrop 1 * Digital high-speed microscope A-i-O Software MAT Software Full connector and tubing kit Flow EZTM supply kit Figure 5: PLGA microparticle production station, full pack content Set-up overview Figure 6: PLGA microparticle production station, full pack set-up

Please refer to the Good Practice Guide. ^Depending on PLGA concentration (see PLGA microparticle synthesis application note) **For detailed specification: download LineUP™ User Manual, ESS™ User Manual.