Introduction
The study explores the enhancement of microneedling results through the Oxyneedling® technique, which combines microneedling with medical oxygen infusion. This non-ablative procedure aims to stimulate collagen and elastic fiber synthesis.

Methodology
The study involved 30 female participants aged 35-45, all with similar morphological features and medical histories. The procedure was applied to areas such as the saddlebags, abdomen, and face. Classic needling was performed using a DTS roller with needles of varying lengths, followed by MBE Oxygen Infusion. Key variables evaluated included skin hydration, sebum content, skin elasticity, and dermal restoration.

Evaluation Criteria
Measurements were taken at four intervals: before treatment, one week after, 45 days after, and six months after treatment. Histological evaluations involved biopsies fixed in a 4% pFA solution, dehydrated, and stained for analysis.

Results
Classic needling showed improvements in fibroblast replication, skin hydration, elasticity, and sebum production. The combination with oxygen infusion significantly enhanced results, with a 55.3% improvement in elasticity and 39.4% in hydration. The study confirmed the effectiveness of both techniques, with Oxyneedling® showing superior results.

Conclusions
The study concludes that microneedling, especially when combined with oxygen infusion, effectively improves skin elasticity and hydration. The process induces fibroblast migration and proliferation, leading to the development of granulation tissue, which is remodeled over time.

Key Findings
- Oxyneedling® significantly enhances skin elasticity and hydration compared to classic needling.
- The procedure is non-ablative and economically advantageous.
- The combination of needling and oxygen infusion is innovative and effective.

Contact Information
Dr. Domenico Amuso: [email protected]

References
The document cites various studies on transcutaneous oxygen measurements and their implications for skin treatment.