Xuri . Believe in better futures. ™ Finding solutions. Advancing breakthrough cell therapies.

Our commitment Engineering innovation GE Global Research Center is the hub of technology development for all of GE’s businesses with employees representing many disciplines of science and technology. Our scientists and engineers redefine what’s possible by finding answers to some of the world’s toughest problems and driving growth for our businesses. We innovate twenty-four hours a day, with sites in Niskayuna, New York; San Ramon, California; Bangalore, India; Shanghai, China; Munich, Germany; and Rio de Janeiro, Brazil. For more information visit www.ge.com/research Building the infrastructure...

Seamlessly go from research to manufacturing To bring a cell therapy product from research to the clinic and into commercial-scale manufacturing quickly, on budget, and with minimal process optimization both the regulatory and technical requirements of increasing scale should be taken into account from the initial process setup. We understand the requirements for each phase of cell therapy production and our products and services ease the progression to commercialization because they can be readily incorporated in to cell manufacturing SOPs. .■Clinical research .-Process develoment • Facilitated...

Immunotherapy: Cell isolation Making immunotherapy a reality GE Healthcare products maximize your chances of success in cell therapy manufacturing by helping to preserve as many precious cells as possible during both the initial cell separation and the expansion of immune cells. They can be readily included in cell manufacturing SOPs facilitating regulatory approval and easing the progression from research to manufacturing. Cell separation Cell selection Cell activation and expansion Cell harvest and concentration Cell infusion into patient Typical immunotherapy workflow. Cell isolation With...

Immunotherapy: Cell isolation Ficoll-Paque PREMIUM Percoll PLUS Ficoll-Paque PREMIUM products are sterile, ready-to-use density centrifugation media solutions manufactured under a Quality Management System certified to ISO 13485:2003 and follow USP <1043> standards for facilitated adoption into cell therapy manufacturing protocols*. Ficoll-Paque PREMIUM solutions are optimized to obtain different types of mononuclear cells from peripheral blood, bone marrow, and umbilical cord blood by density gradient centrifugation. For flexibility and in order to maximize recovery of precious patient cells,...

Immunotherapy: Cell expansion Cell expansion GE Healthcare cell expansion systems, bioreactors, and reagents are designed to address the technical and manufacturing needs of laboratories and units producing cells for cell therapy and progressing towards scale-out or scale-up. The systems are suitable for use in regulated environments and can be used in clinical research, process development, and manufacturing. Xuri Cell Expansion Systems help you progress the manufacture of cells from research to the clinic in a seamless way thanks to their scalability and the functionally closed Cellbag™ bioreactors....

Immunotherapy: Cell expansion Xuri Cell Expansion System W5 Xuri Cell Expansion System W5 (formerly known as WAVE Bioreactor™ 2/10 System) is ideally suited to research-scale cell culture or for the early stage of scale-up and scale-out prior to the commercial manufacture of cell-therapy products. This easy-to-use system allows production of large numbers of cells in a single-use Cellbag bioreactor more efficiently and cost-effectively than manual tissue culture flask-based systems. The system is suitable for culture volumes from as low as 300 mL up to a total of 5 L. Its use has been optimized...

Immunotherapy: Cell expansion Xuri Cell Expansion System W25 Xuri Cell Expansion System W25 has been specifically designed for cell therapy manufacturing applications. To allow for easy progress from the research environment without the need to re-validate, Xuri Cell Expansion System W25 utilizes the same single-use Cellbag bioreactors as the Xuri Cell Expansion System W5. The Xuri Cell Expansion System W25 is suitable for processing volumes from 300 mL up to 25 L using the appropriate base tray and Cellbag bioreactor. This functionally closed system is based on proven wave rocking technology...

Immunotherapy: Cell expansion Xuri Cell Expansion System W25 offers the following advantages in addition to those provided by the Xuri Cell Expansion System W5. • Advanced control of cell expansion through process monitoring and remote operation with UNICORN software. • Suitability for use in a regulated environment with full operational traceability and adherence of the software to CFR part 11 and GAMP5. • Backup storage of data in the base unit. • Minimized hands-on time with control of up to three systems simultaneously from a single UNICORN client. Connection of up to 32 systems to one database...

Immunotherapy: Cell isolation Making stem cell therapy a reality Mesenchymal stromal cell isolation The relatively easy harvesting and expansion procedures of mesenchymal stromal cells (MSCs) together with their ability to differentiate into osteoblasts, adipocytes, and chondroblasts under standard in vitro conditions, may make them suitable for several autologous and allogeneic transplantation settings. Factors challenging the adoption of MSCs for cell therapy at a commercial level are the variability in cell culture conditions, safety, and the long term supply issue, all of which result from...

Immunotherapy: Cell expansion Xuri MSC Medium Serum-free/Xeno-free has been developed to ensure sustainability of MSC cultures when reaching higher volumes and broader applicability in cell therapy. It enables safe and efficient expansion of MSCs after isolation from different tissue origins (including bone marrow, adipose tissue, and umbilical cord) without the use of animal-derived components or undefined serum (Fig 8). Xuri MSC Medium Serum-free/Xeno-free is intended for use with Xuri MSC Attachment Solution for the expansion of cells to the high numbers required for therapeutic doses, without...