Tablet-Compression-171069

Tablet-Compression-171069
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Tablet-Compression-171069

Product catalog summary
Introduction
This document explores advancements in tablet compression technology, emphasizing systems that independently measure and control tablet weight and hardness. The goal is to improve productivity and product quality for pharmaceutical and industrial sectors.
Innovative Technology
The Air Compensator is a key innovation, ensuring consistent pre-compression force for uniform tablet density and weight. It offers benefits like higher sensitivity at low compression forces, extended dwell times, and enhanced tablet quality.
Operational Excellence
GEA integrates Six Sigma and lean manufacturing to minimize process variation and waste, enhancing tablet quality and profitability. Collaboration with customers is emphasized to optimize processes and expedite market entry.
Higher Weight Sensitivity and Extended Dwell Time
The Air Compensator provides precise control over tablet weight and hardness, improving de-aeration, reducing hardness issues, and increasing output. It also allows for rapid changeovers and greater flexibility.
Dual Process Control
GEA's dual control system separates weight and hardness control into independent loops, improving tablet safety and quality. It automatically rejects tablets that do not meet specifications.
Existing Tablet Weight Control Loops
Traditional systems lack precision at lower forces. GEA's displacement-controlled system measures thickness variations at pre-compression, offering improved control loop precision.
Independent Weight and Hardness Control
A secondary hardness control loop maintains constant tablet hardness by adjusting the main compression height, ensuring all parameters remain within tolerance limits despite changes in powder characteristics.
Advanced Dual Control
The PERFORMA™ P and MODUL™ P tablet presses feature advanced dual control for precise weight and hardness control, crucial for medium-volume production and R&D. The dual reject feature maintains batch consistency by rejecting out-of-tolerance tablets, reducing wastage.
Benefits of Dual Control
  • Individual control of tablet weight and hardness.
  • High sensitivity weight control for small tablets.
  • Consistent dwell time regardless of machine speed.
  • Improved tablet quality and productivity.
  • Reduced capping and sticking.
  • High-speed operation with dual reject feature.
PERFORMA™ Range of Tablet Presses
The PERFORMA™ Lite is a high-performance tablet press for heavy-duty applications, featuring an exchangeable turret for quick changeovers. The MULTI-CONTROL 5 system ensures regulatory compliance and comprehensive process control.
PERFORMA™ P Features
  • Exchangeable turret and die disc for quick changeover.
  • High sensitivity weight control and dual reject feature.
  • Optional bilayer operation for flexible production.
  • Medium throughput up to 286,000 tablets/h.
MODUL™ Range of Tablet Presses
The MODUL™ range features the Exchangeable Compression Module (ECM) for unmatched productivity and flexibility, ideal for operations with potent APIs. The WOL-ECM variant enhances safety and contamination control.
MODUL™ P Features
  • Standard or Wash-off-Line ECM for high containment.
  • Single and bilayer capabilities.
  • Choice of compression modes and high sensitivity weight control.
  • Fast product changeover and improved productivity.
Overview of MODUL™ Tablet Presses
GEA's MODUL™ series of rotary tablet presses are highlighted for their advanced features and efficiency, suitable for various pharmaceutical manufacturing needs. Models include MODUL™ P, Q, S, and D, each designed for specific production scales.
Key Features Across MODUL™ Series
  • Advanced Dual Control for precise tablet weight and hardness control.
  • Exchangeable Compression Module (ECM) for quick changeovers and high containment.
  • High throughput capabilities and reduced risk of capping and lamination.
  • Comprehensive containment solutions for handling potent APIs.
Case Study: Haupt Pharma
A case study of Haupt Pharma demonstrates the efficiency and containment performance of MODUL™ presses in processing highly potent APIs.
Conclusion
GEA's MODUL™ tablet presses provide advanced solutions for pharmaceutical manufacturing, combining high productivity with robust containment and flexibility, particularly suited for challenging formulations and potent APIs.
Overview of GEA's ECM Technology
GEA's ECM technology reduces tablet press cleaning downtime from 8-12 hours to less than 2 hours, using an isolated dust-tight module for product-contact parts. The Wash-off-Line (WOL) ECM allows off-line cleaning, enhancing productivity.
Benefits of WOL System
  • No special room requirements, reducing infrastructure costs.
  • Lower water consumption and waste treatment needs.
  • Minimized risk of corrosion and contamination.
  • High containment level and cost efficiency.
MUPS Production Challenges and Solutions
GEA's system minimizes segregation in Multiple Unit Pellet System (MUPS) tablets, enhancing yield and quality through continuous dosing, blending, and compression.
Patented GEA MUPS Solution
  • Two feeders for pellets and excipients ensure uniform mixing.
  • A powder dosing valve (PDV) prevents segregation during transfer.
  • Modified feeder design reduces pellet damage.
Enhanced Process Yield and Content Uniformity
  • Stable content uniformity reduces batch rejection risk.
  • Significant reduction in start-up losses.
  • Efficient process control with minimal product loss.
A-Type Tooling for MODUL™ and PERFORMA™ Presses
A-type tooling increases production capacity by accommodating more stations, optimizing quality and reducing powder loss.
Control Systems
The GEA MULTI-CONTROL 5 system offers comprehensive monitoring and control, compliant with 21 CFR PART 11, enhancing operational efficiency and compliance.
Data Acquisition and Analysis System (DAAS)
DAAS provides in-depth analysis of the tableting process, aiding in troubleshooting and ensuring full traceability of compression events.
Tablet Weight Control
The system uses tablet thickness variations to adjust die fill depth, offering precise weight control and reducing operator dependency.
Integrated Systems and Services
GEA offers integrated production lines with complementary equipment, reducing costs and enhancing communication. Training and remote assistance are available to maximize productivity.
Technical Specifications
  • Single-Layer Setup: Maximum fill depth is 19-20 mm, top punch penetration ranges from 1 to 4 mm, with a maximum pre-compression force of 10 kN and main compression force of 80 kN. Output capacity varies from 126,000 to 244,800 tablets per hour.
  • Bilayer Setup: Top punch penetration for the second layer is 9 mm, with a maximum pre-compression force of 2.5 kN and main compression force of 80 kN. Output capacity ranges from 37,800 to 81,600 tablets per hour.
Machine Specifications/Requirements:
  • Electrical: 3 phase + PE; 380V/400V/415V/460V/480V — 50Hz/60Hz, nominal consumption 6 kW, power installed 11.9 kVA.
  • Compressed Air: Clean & dry; 7–8 bar; 500 L/min.
  • Dust Extraction: 150 m³/h at 15 mbar.
  • Dimensions & Weight: W = 1030 mm x D = 1555 mm x H = 2170 mm — 2500 kg.
Tooling Specifications:
  • Maximum tablet diameter ranges from 11 mm to 35 mm depending on tooling type (D35, D, B, BB, BBS).
  • Punch body diameter ranges from 12 mm to 35 mm.
  • Maximum output capacity ranges from 118,000 to 1,069,000 tablets per hour depending on tooling and setup.
GEA Service Overview:
  • GEA provides comprehensive support throughout the lifecycle of equipment, ensuring optimal performance and operational excellence.
  • Services include installation support, regular maintenance, equipment upgrades, and process optimization.
  • Commitment to enhancing productivity, reducing downtime, and ensuring business success through innovative service models.
Company Information:
  • GEA is a global technology company with operations in over 50 countries, specializing in innovative equipment and process technology.
  • Listed in the STOXX® Europe 600 Index and included in selected MSCI Global Sustainability Indexes.
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Catalog excerpts

Tablet-Compression-171069-1

Tablet Compression Innovation brings challenges, but it’s a challenge we welcome

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Operational excellence For more than a hundred years, our innovation, driven by our passion for excellence, has pioneered tablet compression technology. Allowing pharmaceutical and industrial Our technology is world renowned for its companies to prosper, produce extraordinary reliability, flexibility and economy. We offer products and change people’s lives. truly rapid changeover solutions, increased productivity, flexibility and safety. But it’s much The innovations described in this more than that; it’s about how we work with brochure include a unique technology that you, the customer. We understand...

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Innovative Technology Our Beating Heart We’re constantly looking to overcome hurdles with new technology and present new, unique solutions to the pharmaceutical industry. In fact, innovation is at the heart of all our products; it’s what makes them different. The quest for continuous innovation is the force that drives us every day, and flexibility, performance, accuracy and control are the criteria that focus our thinking. Everything we do is aimed at improving these key factors to help you to make better products and improve productivity. We’re leaders, not followers. We go our own way. We...

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TABLET COMPRESSION ·

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Higher Weight Sensitivity, Extended Dwell Time Air Compensator the unique driving force behind GEA tablet presses The Air Compensator has a prosaic name; however, it’s any- • the displacement of the compression roller results in longer thing but ordinary. At the very core of GEA innovation, it’s what dwell times (up to 300%), better de-aeration, less hardness makes our tablet presses different, and better. It makes them and capping issues and much higher outputs; on some special and it’s why pharmaceutical companies all over the world press models, the main compression dwell time can be set choose...

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No other presses in the world have this technology. The Air Compensator improves product output, overcomes compression issues and facilitates the pressing of small tablets. It makes the impossible possible. The superior process control improves tablet quality by continuously controlling both tablet weight and tablet hardness — optimizing dissolution and bioavailability — as opposed to only weight in a conventional system. Offering weight control at precompression, extended dwell times for complex formulations, higher yields, cost savings and faster setup, the Air Compensator enables you to control...

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Enhanced dual process control, superior tablet quality When tablet weight is monitored at pre-compression, the main Existing Tablet Weight Control Loops compression station is available for a second permanent control Force controlled system: Unlike to the standard control systems loop, which is totally independent from the weight control loop. on most tablet presses, the GEA one does not measure the This second loop eliminates tablet hardness fluctuations and compaction force during main compression for tablet weight automatically compensates for machine warm-up effects. control; the principle...

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It is not possible to re-calibrate the primary tablet weight control loop without affecting tablet thickness or hardness. Displacement controlled system: To address any issues regarding accuracy and repeatability, GEA adopted a different tablet weight control principle for rotary presses, based on • measurement of “thickness variations under fixed compression force” instead of “force variations under fixed thickness” • measurement during pre-compression instead of main compression. The most important characteristic of this principle is the linear relationship between what is measured (thickness...

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Independent Weight and Hardness Control Enhanced dual process control, superior tablet quality The GEA Additional Hardness Control Loop The hardness control loop is re-calibrated after manual or As the GEA weight control loop measures thickness variations automatic sampling and analysis, by changing the set point of (displacement) at the pre-compression station, the main the main compaction force. The change in force set point is compression station is left unused. As such, the main compression calculated on the basis of the difference between the real average height is set to the correct tablet...

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Benefits of Dual Control • Individual control of tablet weight and hardness • High sensitivity weight control even for small tablets and those requiring low compression forces • Maintain the same dwell time regardless of the linear speed of the machine • Improved tablet quality • Improved productivity • Better tablet consistency • Reduced capping and sticking • High-speed operation • Dual reject feature. Applying the latest technologies and getting the most out of them to make our machines even better gives me a great sense of achievement. It makes me proud to be able to deliver top quality equipment,...

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The PERFORMA™ Range of Tablet Presses Original, Effective and Economical – PERFORMA™ Lite The essence of robust and reliable performance The GEA PERFORMA™ Lite is a robust, high performance, fully automatic tablet press that is ideally suited to heavy duty, high-yield applications. The PERFORMA™ Lite is the original GEA press, the technology behind the entire pharmaceutical range. It is flexible, reliable, fully accessible and offers outstanding, cost-effective productivity. The PERFORMA™ Lite includes many standard features and, as with all GEA tablet presses, it also benefits from the unique...

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The PERFORMA™ Range of Tablet Presses Exchangeable Turret A key feature is the exchangeable turret, which allows maximum • Fast product changeover flexibility and enables product changeover in just 30 minutes • Accurate tablet weight control at pre-compression using a semi-automatic exchange sequence. This minimizes • Extended dwell times and high throughput downtime, maximizes productivity and allows easy access to the compression area for cleaning and maintenance. Service Station Data Collection Customer service is much more than providing spare parts, it’s The MULTI-CONTROL 5 is the latest...

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*Prices are pre-tax. They exclude delivery charges and customs duties and do not include additional charges for installation or activation options. Prices are indicative only and may vary by country, with changes to the cost of raw materials and exchange rates.