n/ GeneseeqHRD (PanaseeGP™) is a CE-marked in vitro diagnostic solution designed for evaluating homologous recombination deficiency (HRD) in solid tumor patients. This test analyzes genomic instability and mutations in Homologous Recombination Repair (HRR) pathway genes to thoroughly assess HRD status. f r PARP Inhibitor Therapy - Provides a genome-wide HRD assessment to optimize the use of PARP inhibitors. This includes: Detection of HRR gene alterations: Identifies deleterious alterations in HRR pathway genes, including both somatic and germline mutations in BRCA1/2. Genomic Instability Analysis: Evaluates HRR-related genomic instability markers such as loss of heterozygosity (LOH), telomeric allelic imbalance (TAI), and large-scale state transitions (LST) to determine HRD status. Validated HRD score: Offers an HRD score validated by whole genome sequencing and clinical samples to effectively match patients with PARP inhibitor therapy. r Comprehensive Coverage and Broad Clinical Applicability - Covers critical exons and translocation-related introns in 437 known actionable genes of solid tumors, aligning with guideline-recommended biomarkers. Suitable for patients with ovarian cancer, breast cancer, prostate cancer, pancreatic cancer, and other solid tumors. P Targeted Therapy Decisions Identify crucial genes to inform targeted treatments, such as EGFR, BRAF, ALK, RET, ROS1, KRAS, ERBB2, MET, and NTRK. Microsatellite Instability (MSI): Detects alterations in POLD1/POLEgenes, DNA mismatch repair (MMR) genes (MLH1, MSH2, MSH6, PMS2), and microsatellite sites. Tumor Mutational Burden (TMB): allow calculation of TMB using a validated algorithm. Copyright © 2025. GENESEEQ Technology Inc. All rights reserved.

COMPREHENSIVE GENOMIC PROFILING ‘Please see sample requirement Information sheet for sample collection, storage, and shipment details. -/ Report expected in 5-7 days form sample receipt.}: Copy Numbervariants Tumor Mutational Burden(CNVs) (TMB) IVD/RUO Reagent Kits Kits contain reagents required for entire NGS workflow Customer service Lab space design & setup consultation, staff training and technical support Nucleic acid extraction Library preparation Targeted enrichment Automated NGS workflow Validated workstation adpated for NGS experiments Built-in analysis solutions GENESIS software for...