COMPREHENSIVE GENOMIC PROFILING EssencareTMLung Cancer CDxNMPA-approvedAbout Essencare™^ The Essencare™ Lung Cancer CDx Panel is a focused genomic profiling solution for patients with advanced lung cancer using hybrid capture-based next-generation sequencing.The panel includes six key driver genes to support therapy selection with approved targeted treatments and eight clinically relevant genes to understand disease mechanisms and aid clinical decision-making for emerging therapeutics. fKey Features v/ Panel includes 14 core lung cancer genes: EGFR, ALK, ROS1, BRAF, KRAS, HER2, RET, MET, NRAS, PIK3CA, AKT1, PTEN, NF1, MEK1 v' Four CDx indicationsv' Fully validated for SNV, Indel, CNV, Fusion with high detection sensitivityCompanion diagnostics (CDx) indications Biomarker Prevalence in NSCLC NMPA-Approved Therapy EGFR exon 19 deletion & EGFR L858R 45%-55% Iressa® (gefitinib) Conmana® (icotinib) EGFR T790M >50% Tagrisso® (osimertinib) ALK rearrangements 5%-10% Xalkori® (crizotinib) Validated through large-scale clinical studies 'Z Comparative studies with gold-standard methods, including fluorescent PCR, FISH, and Sanger sequencing, showed an overall concordance rate above 98%. ^ Consistency analysis with approved EGFR, ALK, and ROS1 companion diagnostic kits demonstrated 100% overall agreement. Retrospective clinical studies: patients with EGFR sensitizing mutations or ALK/ROS1 fusions detected by Essencare achieved therapeutic outcomes consistent with those observed in prior clinical trials. Copyright © 2025. GENESEEQ Technology Inc. All rights reserved.

COMPREHENSIVE GENOMIC PROFILING Sample Requirement Tumor Tissues: FFPE Slides: 5-15 slides (Or unstained slides of biopsy or surgical specimen) Extracted gDNA from fresh tissue or FFPE: at least 100 ng Turnaround Time Report expected in 5-7 days form sample receipt.‡ Variant Types Single Nucleotide Variants (SNVs) Small Insertion and Deletion Variants (indels) Gene Translocations IVD/RUO Reagent Kits Kits contain reagents required for entire NGS workflow Built-in analysis solutions Customer service Nucleic acid extraction Library preparation Targeted enrichment Validated workstation adpated for...