GeneseeqHEM (Hemasalus™)®DNA-Seq and RNA-SeqAbout GeneseeqHEM (Hemasalus™) GeneseeqHEM (Hemasalus™) is a CE-marked in vitro diagnostic solution designed for patients with hematologic malignancies. This test integrates DNA sequencing with whole transcriptome mRNA sequencing of 475 genes related to hematologic malignancies to provide optimal coverage and comprehensive analysis of gene translocations and expression changes. f r RNA-Seq for Fusion Detection and Expression Profiling - • Covers 400+ Recombination Signal Sequences (RSSs) involved in V(D)J recombination to facilitate genomic translocation detection involving IG/TR genes. • Combination of DNA-sequencing and whole transcriptome mRNA-sequencing for optimal coverage and comprehensive evaluation of gene translocations and expression changes. • Characterizes hematologic molecular subtypes. i- Comprehensive Genomic Profiling - Selects gene translocations in 475 genes related to hematologic malignancies. r Support for Targeted Therapy - Employs DNA-sequencing to detect Single Nucleotide Variants (SNVs), small Insertion and Deletion variants (indels), Copy Number Variants (CNVs). Covers all exons and translocation-related introns of MYC, BCL2, BCL6, and CCND1. r Monitor and Hereditary Risk management - Detects minimal residual disease (MRD), monitors drug efficacy, and tracks tumor recurrence to guide ongoing treatment. Hereditary Risk Assessment: Assists in identifying hereditary cancer risks for early intervention and preventive care. Tumor Tissue (within two years): FFPE Slides: 5-15 slides ^Extracted gDNA: at least 100 ng s/Extracted RNA: at least 100ng Liquid Biopsies: Peripheral Blood: 8-10 ml of whole blood v/ Bone Marrow: 100 |jLExtracted gDNA: at least 100ng total Extracted RNA: at least 100ng *Please see sample requirement information sheet for sample collection, storage, and shipment details. Copyright © 2025. GENESEEQ Technology Inc. All rights reserved.

COMPREHENSIVE GENOMIC PROFILING Gene Fusion IG/TR Rearrangement Molecular Subtyping Turnaround Time Report expected in 5-7days from sample receipt. ‡ Single Nucleotide Variants (SNVs) Small Insertion and Deletion Variants (indels) Copy Numbervariants (CNVs) IVD/RUO Reagent Kits Kits contain reagents required for entire NGS workflow Built-in analysis solutions Customer service Nucleic acid extraction Library preparation Targeted enrichment Validated workstation adpated for NGS experiments GENESIS software for automated bioinformatic analysis and reporting Lab space design & setup consultation,...