About GeneseeqPrime >/ GeneseeqPrime is a comprehensive genomic profiling (CGP) test designed for advanced-stage patients with solid tumors. The test identifies alterations in 437 genes and evaluates tumor mutational burden and microsatellite instability using tissue or liquid biopsy samples. f Covers of critical exons and translocation-related introns in 437 known actionable genes of solid tumors, including guideline-recommended biomarkers. Ulitizes ctDNA-based liquid biopsy to monitor disease progression and assess the risk of tumor recurrence and metastasis following surgery or treatment. Targeted Therapy - Identifies crucial genes to inform targeted treatments, such as EGFR, BRAF, ALK, RET, ROS1, KRAS, ERBB2, MET, and NTRK, and access wide range of genes associated with drug resistance to guide treatment options at progression. - Immunotherapy Decision-Making - Identifies Microsatellite Instability (MSI) through alterations in microsatellite sites, Mismatch Repair (MMR) genes (MLH1, MSH2, MSH6, PMS2), and POLD1/POLEgenes, and calculate Tumor Mutational Burden (TMB) using a validated algorithm. ,-PARP Inhibitors - Assesses somatic and germline BRCA1/2 alterations, along with homologous recombination repair (HRR) genes, to optimize PARP inhibitor therapy. r Hereditary Cancer Risk Assessment- Informs and guide early cancer screening and intervention strategies by identification of crucial germline mutations. Sample Requirement* Tumor Tissues: •y FFPE slides: 5-15 slides "S Extracted gDNA: at least 100ng Liquid Biopsies: y Peripheral blood: 8-10ml of whole blood -•/ Extracted ctDNA: at least 8ng total amount and 4ng/mL y Test adapted to other body fluids, such as pleural effusion, cerebrospinal fluid, aqueous humor, and urine (Please consult for sample collection requirements) *Please see sample requirement information sheet for sample collection, storage, and shipment details. Copyright © 2025. GENESEEQ Technology Inc. All rights reserved.

COMPREHENSIVE GENOMIC PROFILING Turnaround Time Report expected in 5-7days from sample receipt. ‡ Variant Types Small Insertion and Deletion Variants (indels) Gene Translocations Single Nucleotide Variants (SNVs) Copy Numbervariants (CNVs) Tumor Mutational Burden (TMB) IVD/RUO Reagent Kits Kits contain reagents required for entire NGS workflow Built-in analysis solutions Customer service Nucleic acid extraction Library preparation Targeted enrichment Validated workstation adpated for NGS experiments GENESIS software for automated bioinformatic analysis and reporting Lab space design & setup consultation,...