Automated Disposable Pipette Extraction Revolutionary SPE technique Fast extraction and high recovery Low limits of detection Fully automated

Add solvent, internal standard or reagent Introduce an aliquot of the DPX-eluate to the GC or LC system MAESTRO PrepBuilder page for the DPX method. All sample preparation steps are conveniently and easily selected from a drop down menu and added to the method. Disposable Pipette Extraction DPX Disposable Pipette Extraction (DPX) is a fast and efficient SPE technique used for a wide range of applications such as drugs of abuse, therapeutic drug monitoring, comprehensive screening, pharmacology studies, as well as pesticides in fruit and vegetables. DPX is based on unique and patented SPE devices:...

The DPX advantage GC/MS Applications 1 Rapid sample extraction • Equilibration and elution occur in seconds • Conditioning steps generally not required • DPX clean-up is faster than the GC or LC run and is easily performed in parallel to the analysis. The next sample is always ready for introduction when the GC or LC has finished its run for optimized productivity and throughput 2 Low detection limits • Less than 250 pL of blood or urine required to reach very low detection limits, when combined with large volume injection • Minimal elution volume, effectively providing a concentration step •...

DPX-LC/MS/MS Drug Screening Automated extraction and determination of 40 drugs in urine using automated DPX-LC/MS/MS. Samples of 276 pL hydrolyzed urine spiked with drugs were diluted with 500 pL acetonitrile, vortexed and transferred to a DPX-SC tip. After automated DPX the sample was evaporated and reconstituted using 100 pL of methanol / 0.05% formic acid (1:1 v/v). The analysis was performed using an Agilent 1200 HPLC with a Zorbax Eclipse Plus column DB-C18, 2.1x100 mm, 1.8 pm and an Agilent 6410 TripleQuad Mass Spectrometer (ESI, dynamic MRM, positive mode). LC-Conditions Injection Volume: Mobile...