Innovative Solutions for Process Analytics in Biotechnological and Pharmaceutical Industries
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Innovative Solutions for Process Analytics in Biotechnological and Pharmaceutical Industries - 1

Innovative Solutions for Process Analytics in Biotechnological and Pharmaceutical Industries

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Innovative Solutions for Process Analytics in Biotechnological and Pharmaceutical Industries - 2

Continuous Process Improvement More measurement parameters and less measurement error yield tighter process control Take advantage of our demonstration program to see firsthand how the right sensor can improve your process Process Understanding Hamilton maintains an intense focus on new technologies that address the upcoming needs of our biopharmaceutical customers. Our goal is to provide new online sensing technologies that are robust and provide actionable data to improve process understanding. Process Improvement It is not always simple to evaluate new sensor technologies. The cost of...

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Tomorrow’s Innovations Coming soon: new online sensors for common offline measurements No preparation, sterilization, or calibration by customers; gamma sterilizable sensor capable of dry storage Online Viable Cell Density Process optimization and control based on real-time measurement of viable cells Intelligent Sensors Integrated transmitter reduces installation, troubleshooting, and calibration costs 2007 Optical Oxygen Sensors No polarization reduces maintenance and troubleshooting time Prepressurized pH Sensors 6 bar internal pressure minimizes reference and process contamination Glass...

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The Intelligent Sensor Revolution Over 95% of process engineers surveyed find value in using smart sensors Less than half of engineers felt they fully utilized their smart sensor. The key to getting the most out of your smart sensor is choosing the implementation that best fits your application. Hamilton offers two versions of smart sensors each equipped with our best-in-class measurement technology. Cost Comparison  Analog Sensors HIGH Traditional analog sensors offer the lowest sensor cost which is ideal for implementations that discard the sensor after each run. They rely on a...

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Grab Sensor Grab buffers and head to reactor Attach sensor and calibrate Failed calibration Attach new sensor and calibrate Document sensor history Troubleshoot active process Recertify sensor at metrology Document current health of sensor Lower Operating Costs Transmitters are large and bulky, requiring them to be permanently installed at-line. Intelligent sensors have an integrated transmitter thanks to advances in microprocessors. The result is a profound improvement in the sensor handling workflow. ■■    Reduce installation costs by eliminating transmitters can happen anywhere and can...

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The top bioreactor manufacturers deliver reactors with Hamilton sensors installed Bioreactor performance is dependent on having reliable access to actionable data. Manufacturers choose Hamilton’s diverse product offering to deliver to their customers relevant process parameters with exceptional life and low maintenance. Retrofitting Existing Bioreactors Hamilton offers sensors that are compatible with any bioreactor and provide improved measurement stability and sensor life. Upgrading to an intelligent sensor will lower operating costs with automatic reporting, batched in-lab calibration,...

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New Tools Viable Cell Density (VCD) Incyte Arc Sensors Cell counting and trypan blue staining, as well as other offline measurements of viable cell density are labor intensive, prone to contamination, and provide limited data. Instead of two measurements per day Incyte provides continuous data resulting in faster optimization of feeding and harvesting strategies. Total Cell Density (TCD) Dencytee Sensors Most Optical Density probes lose linearity as cell density increases. Dencytee’s variable NIR light source increases intensity to maintain sensitivity with low- and high-density cultures....

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Seamless Scale-up to Production Sensors that last longer and require less maintenance Hamilton is known for high quality materials and craftsmanship that result in exceptional sensor life. With the introduction of the Arc sensors Hamilton took ownership of the measurement loop and pioneered advances in sensor calibration, troubleshooting, connectivity, and documentation.

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Hamilton assists you to better understand the functionality and use of your sensors with a familiarization demonstration. Trained service engineers are available to commission, qualify, and verify your sensor installation and deliver audit-quality reports that can be shared with your regulatory body. On-site calibrations require a lot of preparation and logistic effort. Arc sensors can be calibrated in the lab and stored ready to use on the shelf. Maintenance and Troubleshooting Cleaning Cleaning in Place (CIP) and Sterilization in Place (SIP) are very challenging treatments for the...

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Product Offering Equipment, sensors, and accessories for complete loops For more than 25 years, Hamilton has developed sensors, housings, and buffers to meet the evolving needs of pharmaceutical and biotechnology customers. Our extensive product selection is certified to meet or exceed all FDA and GMP regulatory standards. Measurement Parameters All relevant measurement parameters for BioPharma applications are part of the Hamilton portfolio. Electrical Connectors Regardless of which electrical connector, analog or digital, Hamilton provides sensors with the compatible head. Visi Family

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Process Insertions Sensors can only perform as they ought to with the appropriate process connection or housing. Hamilton housings are designed to fulfill aIl cleanability and sterilization requirements. If special solutions are required, Hamilton’s application engineering team is more than happy to develop a customized solution. Calibration & Validation All calibration procedures assume that the labeled values of the calibration buffers are correct. But buffer values can change over time and so can the results. A complete range of patented buffer solutions provides pH stability up to 5...

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Biopharmaceutical Roadmap Every step of the biopharmaceutical process has specific requirements for sensors to monitor and control it precisely. The roadmap below shows the individual recommendations from the Hamilton portfolio. Pharmaceutical Grade Water (PW, UPW, WFI) Media Prep Tank pH: EasyFerm Plus, EasyFerm Bio, Polilyte Plus Conductivity: Conducell 4USF pH: Polilyte Plus Conductivity: Conducell UPW Bioreactor pH: EasyFerm Plus, EasyFerm Bio DO: VisiFerm, OxyFerm FDA Viable Cell Density: Incyte Arc Total Cell Density: Dencytee UPSTREAM Heat Sterilizer Receiver Tank Air Filter Seed...

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