BPro ® Real-Life Case Study #2 Nocturnal Hypertension BPro 24-hr Ambulatory Blood Pressure Monitoring ® [ABPM] Live Experience. Patient Profile Before undergoing ABPM Age : 64 years Sex : Female Race : Chinese Medical History : Hypertension for 3 years. Also high cholesterol Medication : On statin for cholesterol and calcium channel blocker (CCB) & B-blocker for hypertension for the last 3 years. Clinic BP : 145/85 mmHg Heart Rate : 61 bpm BP measurements relied on sphymo cuff measurement. First BPro® ABPM Profile • Date: 14 January 2006 Diagnosis: The 24-hr ABPM profile indicated that the patient has border-line hypertension. This patient also manifested as non-dipper i.e. the night time sleep BP does not dip between 10% - 15% (see arrow indicated on chart above). The medication provided is obviously not effective, and further remedial actions are not implemented due to lack of availability of evidence-based data on the efficacy of the prescribed medication and blood pressure. HealthSTATS International Proprietary Information

BPro ® Action taken: The patient was taken off B-blocker and calcium channel blocker. Angiotensin Receptor blocker was prescribed to be taken for the morning and diuretics for the evening. Second BPro® ABPM Profile – 3 months later • Date: 15 April 2006 Diagnosis: The 24-hr ABPM profile indicated that this patient night time sleep BP pattern has returned to normal i.e. it dips to between 10% - 15%. Furthermore, the borderline hypertension is also well controlled. Conclusions: The above case illustrated the power of evidence-based approach in the treatment of hypertension in using 24-hr ABPM incorporating...