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COPAL® G+C

Product catalog summary

Introduction
Understanding patient risk factors is crucial in reducing the risk of periprosthetic joint infection (PJI) following arthroplasty. High-risk patients, identified by factors such as diabetes, cardiovascular disease, obesity, previous infections, smoking, older age, and revision surgery, require intensified preventive measures.

Risk Stratification and Prevention
Approximately 60% of patients aged 65 and older are at higher risk for infection. An integrated preventive approach, including surgical optimization and peri-operative antibiotic prophylaxis, is essential. Dual antibiotic-loaded bone cement, such as COPAL® G+C, is recommended for high-risk groups, particularly those with fractured neck of femur (FNOF).

Clinical Evidence
Clinical studies show a reduction in PJI rates with the use of COPAL® G+C in various scenarios: elective primary hip and knee arthroplasty, trauma cases like fractured neck of femur, and aseptic revision total knee arthroplasty.

Preventive Measures
Key measures include skin preparation, wound irrigation, management of anemia and malnutrition, perioperative blood management, optimization of comorbidities, systemic antibiotic prophylaxis, maintaining normothermia and oxygenation, and the use of dual antibiotic-loaded bone cement.

Dual Antibiotic-Loaded Bone Cement
This cement, containing Gentamicin and Clindamycin, is indicated for implant fixation and offers a broad spectrum of activity against pathogens relevant to PJI. It provides high local antibiotic concentrations with minimal systemic load, effectively targeting up to 90% of typical PJI pathogens, including anaerobic ones.

Conclusion
Incorporating dual antibiotic-loaded bone cement into a risk-adapted approach significantly contributes to infection prevention in high-risk arthroplasty patients.

Catalog excerpts

KNOW YOUR PATIENT – AND REDUCE PJI RISK

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– KNOW YOUR PATIENT … APPROX. 60 % OF PATIENTS AGED ≥ 65 YEARS ARE AT HIGHER RISK FOR INFECTION*1–3 rthroplasty patients benefit from an integrated preventive approach according to infection A risk stratification1 igh risk patients require intensified prevention measures that include the use of high-dose H dual antibiotic-loaded bone cement4 * Definition of high risk: at least 2 risk factors such as diabetes, cardiovascular disease, obesity, previous infection, smoking, older age, revision surg

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… AND REDUCE PJI RISK. Preventing surgical site infection and PJI following arthroplasty is challenging. Measures include both, optimisation of surgical procedures as well as peri-operative antibiotic prophylaxis.4 An integrated and effective preventive approach reduces PJI risk in patients with risk factors. Dual antibiotic-loaded bone cement COPAL® G+C can be one part in this set of measures.1,5 Skin preparation and wound irrigation Management of anaemia & malnutrition Dual antibioticloaded bone cement Perioperative blood management PJI prevention3,4,6 Preoptimization of comorbidities (e.g....

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Dual antibiotic-loaded bone cement with Gentamicin and Clindamycin Indicated for implant fixation Very broad spectrum of activity against most pathogens clinically relevant for PJI In combination, both antibiotics may target up to 90 % of all pathogens typically found in PJI Effective against anaerobic pathogens amongst others High local antibiotic concentrations with low systemic load Infection prevention as part of risk-adapted approach SOURCES 1. Sanz-Ruiz P, Berberich C. Infection Risk-Adjusted Antibiotic Prophylaxis Strategies in Arthroplasty: Short Review of Evidence and Experiences of...

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COPAL® G+C

COPAL® G+C

Catalog excerpts

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