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COPAL® G+V

Product catalog summary

Introduction
Periprosthetic joint infections (PJI) are a significant cause of revision surgeries. High-dose dual antibiotic-loaded bone cement is crucial in preventing infections post-surgical debridement by providing high local antibiotic concentrations.

Product Overview
COPAL® G+V is a high-viscosity bone cement used for anchoring prosthetic implants during septic revision surgeries, particularly effective against vancomycin-sensitive MRSA and MRSE. It contains gentamicin and vancomycin, targeting a broad spectrum of pathogens.

Pathogen Spectrum
The dual antibiotic combination in COPAL® G+V is active against various pathogens, including:

Coagulase-positive staphylococci (e.g., MSSA, MRSA)
Coagulase-negative staphylococci (e.g., MSSE, MRSE)
Streptococcus spp. (e.g., S. pneumoniae, S. pyogenes)
Enterococcus spp. (e.g., E. faecalis, E. faecium)
Enterobacteriaceae spp. (e.g., E. coli, Klebsiella spp.)
Other Gram-negative bacteria (e.g., Pseudomonas aeruginosa)
Anaerobic bacteria (e.g., Clostridium difficile)

Antibiotic Release and Efficacy
COPAL® G+V offers high initial antibiotic release for up to 28 days, crucial for preventing re-colonization. Comparative analyses show its effectiveness against E. coli and MRSA.

Advantages

Broad spectrum of activity due to dual antibiotics
Effective against vancomycin-sensitive MRSA/MRSE
Permanent anchoring of implants
Contains 0.5 g of gentamicin and 2 g of vancomycin

Ordering Information
COPAL® G+V is available from Heraeus Medical GmbH, with specific product details and reference numbers provided for ordering.

Catalog excerpts

Reducing Periprosthetic Joint Infections

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COPAL® G+V – SUCCESSFUL AGAINST INFECTION Active against most PJI causing pathogens due to the dual antibiotic combination Periprosthetic joint infections (PJI) are a common cause of revision surgery. The use of high-dose dual antibiotic loaded bone cement plays an important role in an effective preventive antibiotic concept following surgical debridement as it provides high local antibiotic concentrations. COPAL® G+V is a high-viscosity bone cement for anchoring prosthetic implants in the case of septic revision surgery in procedures with proven vancomycin-sensitive MRSA / MRSE*. It contains...

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LOCAL ANTIBIOTICS IN REVISION SURGERY Importance of an effective antibiotic combination COPAL® G+V OFFERS HIGH INITIAL ANTIBIOTIC RELEASE UP TO 28 DAYS. COMPARATIVE ANALYSES WITH DRUG-LOADED CEMENTS FOR THE USE IN REVISION ARTHROPLASTY (1) COPAL® G+V – E. coli COPAL® G+V – MRSA VancoGenx™ – E. coli VancoGenx™ – MRSA Time point of measurement (hours / days) modiﬁed from Kunzi et al. 2018 “In order to avoid re-colonisation the choice of the bone cement should be made in a considered way.”1 – JC Kunzi – (1) Kunzi et al. Medical University of Graz and Charité Universitätsmedizin Berlin. 11th Endoprothetikkongress...

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COPAL® G+V – SUCCESSFUL AGAINST INFECTION ADVANTAGES AT A GLANCE Broad spectrum of activity due to the use of two antibiotics Effective against vancomycin-sensitive MRSA / MRSE among others For permanent anchoring of implants Contains 0.5 g of gentamicin and 2 g of vancomycin High-viscosity radiopaque bone cement with gentamicin and vancomycin www.heraeus-medical.com Heraeus Medical GmbH Philipp-Reis-Str. 8/13 61273 Wehrheim Germany Simply order from Heraeu

Open the catalog to page 4

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