Comprehensive Tumor Profiling of Immune Response and Systems Biology
8Pages

Comprehensive Tumor Profiling of Immune Response and Systems Biology HTG EdgeSeq Immuno-Oncology Assay HTG EdgeSeq Oncology Biomarker Panel

HTG provides multiplexed gene expression assays and automation platforms that leverage the power and sensitivity of next-generation sequencing (NGS). Designed to empower precision medicine, HTG's extraction-free chemistry provides more data from small samples, such as microdissected regions from FFPE sections. HTG's solutions can be used by translational and pre-clinical researchers working in the field of cancer immunology and/or cancer immunotherapy. A deeper understanding of immune response and tumor behavior allows for the research of targeted therapies with the goal of improving...

The HTG EdgeSeq Immuno-Oncology Assay characterizes the immune response in tumor microenvironments while the HTG EdgeSeq Oncology Biomarker Panel allows for comprehensive interrogation of the tumor. Sample The sensitivity and dynamic range of next-generation sequencing paired with the specificity of HTG EdgeSeq chemistry enables measurement of the expression of hundreds of genes with minimal sample input required. Profile challenging sample types, including FFPE tissue, to deliver more data from less material. Applications include: ■ Assessing the tumor microenvironment ■ Measuring total T...

Immune Response and Systems Biology Together Analyzing localized regions of tumors can provide insights into how tumors escape immune surveillance. A better understanding of the responsiveness of tumors to specific immuno-oncology-based treatments can be achieved by characterizing the behavior of these regions within the tumor and stroma. Perform analyses of multiple tumor regions using a single FFPE section. Case in Point Faced with extremely limited material from a study cohort, a pharmaceutical development company wanted to reveal the underlying biology in tumor biopsies, understand drug...

HTG A Tumor B Stroma C Peritumoral region HTGEdgeSeq assays allow assessment of individual microdissected regions from as little as 1.5 mm2 of a single 5-micron unstained FFPE tissue section CPMs Fold change Fold changes in expression across a range of FFPE tissue sample input amounts using the HTG EdgeSeq Immuno-Oncology Assay While classic immunophenotyping biomarkers show a similar profile, an analysis with the HTG EdgeSeq Immuno-Oncology Assay of interferon-related and metastasis biomarkers shows a differential response

HTG EdgeSeq Immuno-Oncology Assay Illumina 916-005-208 HTG EdgeSeq Oncology Biomarker Panel Illumina 916-002-208 HTG EdgeSeq Immuno-Oncology Assay ILM (2x8) HTG EdgeSeq Immuno-Oncology Assay ILM (4x8) HTG EdgeSeq Immuno-Oncology Assay ILM (1x24) HTG EdgeSeq Immuno-Oncology Assay ILM (4x24) HTG EdgeSeq Immuno-Oncology Assay ILM (1x96) HTG EdgeSeq Immuno-Oncology Assay IT (2x8) HTG EdgeSeq Immuno-Oncology Assay IT (4x8) HTG EdgeSeq Immuno-Oncology Assay IT (1x24) HTG EdgeSeq Immuno-Oncology Assay IT (4x 24) HTG EdgeSeq Oncology Biomarker Panel ILM (2x8) HTG EdgeSeq Oncology Biomarker Panel...

VERI/O Lab Services Our in-house VERI/O laboratory services support biomarker research and companion diagnostic development using HTG’s extraction-free technology and portfolio of profiling assays. Planned services are expected to include direct sequencing of genetic variants. CLIA-Certified Partners For prospective research, HTG has partnered with several CLIA-certified laboratories that provide profiling services using HTG systems and assays. Contact your HTG representative for more information. Partner with HTG Commitment Comprehensive, NGS-based molecular profiling is a critical tool...

HTC Molecular HTG Molecular Diagnostics, Inc. 3430 E. Global Loop, Tucson, AZ 85706 Customer Support: +1 877 507 3259 Corporate Office: +1 877 289 2615 +1 520 547 2834 Fax: +1 520 547 2837 Service and support: support@htgmolecular.com Orders: orders@htgmolecular.com More information: info@htgmolecular.com C€ HTG Edge and HTG EdgeSeq processors are CE-marked and CSA-certified. For Research Use Only. Not for use in diagnostic procedures.HI HTG EdgeSeq, HTG Edge and qNPA are trademarks of HTG Molecular Diagnostics, Inc. Any other trademarks or trade names used herein are the intellectual...