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BEHAVIORAL RESEARCH

BEHAVIORAL RESEARCH

Product catalog summary

Overview: This document is a catalog from Harvard Bioscience, Inc., detailing a range of products and solutions for behavioral research, electrophysiology, and neuroscience. It highlights the company's commitment to high-quality products and customer support, emphasizing their adaptability to the evolving research market.

Main Sections:

Product Offerings: The catalog lists various tools and systems for research, including video tracking systems, operant conditioning setups, and electrophysiology solutions. Key products include the SMART Video Tracking System V3.0, Modular Operant Box, and TBSI Solutions for neural recording.
Research Applications: The products are designed for diverse applications such as studying brain functions, pathologies like Alzheimer's and Parkinson's, and screening therapeutic compounds. The catalog also covers tools for analyzing behavior in small laboratory animals.
Technical Support: Harvard Bioscience offers extensive pre- and post-sales support, with technical staff available to assist with system configurations and answer questions.
Innovative Solutions: The document highlights the integration of new technologies and the synergy created by combining behavioral analysis with in vivo neuronal recording and stimulation.
Detailed Product Descriptions: Each product section provides detailed descriptions, including key features, parameters measured, and specific applications. For example, the SMART Video Tracking System V3.0 is noted for its flexibility, reliability, and advanced data analysis capabilities.

Key Features and Benefits:

Modular and Flexible Systems: Products like the SMART Video Tracking System offer modular structures to fit various experimental needs and budgets.
Advanced Data Analysis: The systems provide customizable data reports and calculations for a wide range of behavioral paradigms.
Comprehensive Support: The company emphasizes its commitment to customer service and high-quality standards.

Conclusion: Harvard Bioscience, Inc. positions itself as a leader in providing comprehensive and trusted solutions for behavioral and neuroscience research, continuously evolving to meet the needs of the research community.

SMART Packages Overview: The document outlines various SMART packages designed for animal behavioral experiments. The packages include:

SMART Basic Pack: Suitable for one animal in one arena, includes essential modules like SMART V3.0, SMART-RC, SMART-CS, CONVANAUSB, and SMART-GA.
SMART Super Pack: Builds on the Basic Pack with additional modules such as SMART-MA and SMART-TW.
SMART Premium Pack: Offers maximum flexibility by adding modules like SMART-OF, SMART-CPP, SMART-WM, SMART-FST, SMART-PM, SMART-SI, and SMART-TY to the Super Pack.

Video Tracking System: The SMART Video Tracking System V3.0 is highlighted for its capabilities in tracking and analyzing animal behavior. Key features include:

Tracking calculations in various zones and specific calculations like first arm choice and spontaneous alternation triplets.
Time evolution reports and group evolution graphs for comprehensive analysis.

Digital Video Recording Systems: The RECORD-IT! systems provide options for digital video recording to ensure traceability and security. Features include:

Compatibility with multiple cameras and the ability to generate independent digital video files.
Integration with the SMART system and compatibility with other tracking programs.

LimeLight Video Tracking Software: LimeLight is a flexible video tracking system suitable for various applications like Open Field and Plus Maze. It offers:

Simultaneous tracking of up to four arenas with no special lighting required.
Easy zone creation and behavior scoring with export options to Excel for analysis.

Ordering Information: The document provides detailed ordering information for various SMART V3.0 packs, platforms, extensions, and accessories, as well as RECORD-IT! digital video recording systems.

References: The document cites several studies utilizing the SMART system in various experimental setups, highlighting its application in cognitive and behavioral research.

Overview: The document provides detailed information on various video tracking software and behavioral test systems used in animal research. It includes descriptions of LimeLight and WaterMaze software, as well as the Habitest Modular Behavioral Test Systems.

LimeLight Video Tracking Software: LimeLight is a video tracking software that allows users to analyze animal trials. Key features include the ability to view trial movies, analyze trial data in various formats, and export data to Excel. Users can customize grid displays, track animal movements based on body parts, and perform complex analyses. Batch exporting and group analysis are also supported.

WaterMaze Video Tracking Software: WaterMaze is designed for Morris water maze experiments. It features a Project Manager for organizing complex trial sequences and supports robust tracking with standard CCD cameras. The software measures parameters like thigmotaxis and quadrant times, and allows for easy export of data and swim paths. It is user-friendly and integrates seamlessly with experimental routines.

Habitest Modular Behavioral Test Systems: Habitest offers a flexible system for implementing various behavioral test protocols. It includes modular test arenas and stimulus-response devices for experiments like mazes, operant conditioning, and fear conditioning. The system is highly configurable and supports a wide range of stimuli and response sensors.

Ordering Information: The document lists product codes and descriptions for ordering LimeLight, WaterMaze, and Habitest systems, along with their accessories.

References: The document cites several scientific studies that have utilized these systems in research, highlighting their application in neuroscience and behavioral studies.

Overview: This document provides detailed information on various equipment and software used for behavioral research, particularly focusing on operant conditioning systems for mice and rats. It includes specifications, ordering information, and references to scientific studies.

Specifications and Equipment:

Shock Level Tester: A13-16 model with a 25 ft. shock cable.
Gustatory Stimuli: Pellet delivery troughs and feeders for mice and rats, with specific models for different pellet sizes.
Levers and Lickometers: Various models for mice and rats, including retractable and optical versions.
Response Sensors: Contact sensors and infrared activity monitors are available.

Operant Conditioning Systems:

Habitest Modular Behavioral Test Systems: Suitable for a range of experiments including self-administration, variable interval, and operant conditioning.
Graphic State® 4 Software: Enhanced software for designing complex experiments with a user-friendly interface and advanced data analysis capabilities.
Modular Operant Box: A flexible system that can be customized for different experimental needs, supporting up to 8 stations connected to a PC.

Software and Upgrades:

Packwin V2.0 Software: A versatile platform for conducting behavioral experiments, offering advanced reporting and analysis features.

References: The document cites various studies related to behavioral research, providing context and validation for the equipment and methodologies discussed.

Ordering Information: Detailed product numbers and descriptions are provided for easy ordering of equipment and software upgrades.

Overview: The document provides detailed information on the Packwin software and Tru Scan system, both designed for behavioral research experiments. Packwin offers customizable and pre-configured modules for various operant conditioning protocols, while Tru Scan is used for monitoring open field activity in rodents.

Packwin Software:

Customized Module: Allows researchers to create complex protocols without programming knowledge. It supports a variety of operant procedures such as associative learning, memory tasks, addiction studies, attention tests, and anxiety/depression assessments.
Pre-Configured Test Modules: These modules come with ready-to-use templates and data reports for specific experiments like the 5-Choice Serial Reaction Time Test, Vogel Test, fear conditioning, and startle response evaluation.
Parameters Measured: Includes detailed reports on experiment duration, response patterns, and specific metrics for each type of test module.

Tru Scan System:

Key Features: Offers precision tracking in small arenas for mice and rats, with the ability to conduct various behavioral tests. The system is scalable and allows for controlled presentation of stimuli.
Data Analysis: Automated data analysis with results presented in tables or graphs. Raw data can be re-analyzed to discover new behaviors or effects.
Versatility: The system supports multiple experimental protocols and is compatible with various accessories to enhance functionality.

Ordering Information: The document lists product codes and descriptions for ordering Packwin software modules and Tru Scan components, including control and data acquisition systems, arenas, sensor rings, and accessories for both mice and rats.

References: The document cites various studies that have utilized these systems, highlighting their application in research on addiction, memory, attention, and other behavioral studies.

Overview: The document provides detailed information on various systems and software used for monitoring and analyzing locomotor activity and circadian rhythms in rodents. It includes specifications, key features, parameters measured, and ordering information for different products.

Specifications: The systems are designed with interchangeable frames for rearing activity or poking modes and can operate independently or with a computer. They support simultaneous recording of multiple cages or infrared (IR) frames and are compatible with both open field and home cage environments. The systems measure various parameters such as stereotypies, rearings, nose-pokes, and global activity.

Software: The SEDACOM software allows data export to Excel and can be used with ActiTrack for enhanced analysis of animal trajectories. ActiTrack software provides detailed tracking analysis, including distance, speed, and permanence time in selected zones. ClockLab software is highlighted for circadian biology studies, offering sophisticated data analysis tools and compatibility with various sensors.

Key Features: The systems offer flexibility with interchangeable frames, independent operation without a dedicated PC, and compatibility with multiple cages. The ActiTrack software supports up to 32 frames and provides detailed spatial and movement analysis. ClockLab software supports up to 448 channels and offers real-time viewing and analysis of circadian data.

Applications: The systems are applicable in studies involving circadian rhythms, exercise, cognition, and various disease models such as Huntington’s, ADHD, and addiction. The rodent activity wheel is particularly useful for quantifying voluntary exercise in home cage environments.

Ordering Information: The document lists various models and accessories available for purchase, including IR frames, activity wheels, software licenses, and adapters. It also provides references to scientific studies that have utilized these systems.

Overview: The document provides detailed information on various laboratory equipment designed for sensory motor and coordination experiments in small animals. It includes specifications, ordering information, and optional accessories for treadmills, rotameters, rodent shockers, and data transfer software.

Specifications: The equipment features adjustable parameters such as current range (0 to 2 mA), belt speed (5 to 150 cm/sec), and slope adjustment (-25° to 25°). The shock grid dimensions are 190 mm x 100 mm. Power requirements are 110 or 220 Vac, 50/60 Hz, and the equipment is CE compliant.

Procedures: The document outlines the use of electrical shocks and air-puff options as aversive stimuli for forced exercise in laboratory animals. It also describes the use of rotameters for evaluating rotational behavior in rodents, particularly in Parkinson’s disease models.

Norms and Recommendations: The document emphasizes the ethical use of air-puff options over electrical shocks and provides safety features for the rodent shocker, including a security circuit and a security key for trained personnel only.

Ordering Information: Detailed product codes and descriptions are provided for single, double, and 5-lane treadmills, rotameters, rodent shockers, and accessories. The document also lists optional accessories like SeDacom V2.0 software for data acquisition.

Data Transfer Software: SEDACOM V2.0 is highlighted as a versatile data collection software compatible with various devices. It offers both GENERIC and DEVICE modes for data export and device control, enhancing experimental tracking and analysis.

Key References: The document cites studies utilizing the equipment, demonstrating its application in research on exercise modulation, myophosphorylase dysfunction, and anticonvulsant drug testing.

Overview: This document provides detailed information on various devices used for evaluating thermal analgesia in laboratory animals. It includes specifications, key features, components, and options for each device, along with references to scientific studies.

1. Tail Flick Meter:

Key Features: Optimal detection with perfect alignment of heat stimulus and photo beam trigger, adjustable sensitivity, manual and remote timer, automatic cut-off, and optional data transfer software (SEDACOM V2.0).
Parameters Measured: Time latency response to thermal stimulus.
Components Included: Control unit, stimulation unit, mouse tail adapter, holder for rat or mouse, footswitch, instruction manual, calibration certificate, cables, connectors, and spare fuses.
Options: Tail-temperature recorder, SEDACOM software, RS-232/USB adapter.

2. Hot-Plate for Evaluating Thermal Analgesia:

Key Features: Digital set point, built-in electronic timer, foot switch timing operation, and optional data transfer software (SEDACOM V2.0).
Parameters Measured: Time latency to 'paw licking' and 'jumping'.
Components Included: Base with heating plate, footswitch, cables, connectors, calibration certificate, instruction manual, and spare fuses.
Specifications: Temperature range from 45 to 62°C, reaction time precision of 0.01 sec, and CE compliant.

3. Hot/Cold Plate for Testing Animal Sensitivity:

Key Features: Unmatched temperature stability, fast acclimation, homogeneous temperature distribution, and BSRamp software for temperature ramps.
Parameters Measured: Animal reaction time to hot or cold stimulus.
Specifications: Temperature range from -3°C to 65°C, accuracy of ±0.5°C, and automatic power requirements.

4. Thermal Place Preference:

Key Features: Monitor thermal place preference and nociceptive thresholds, unrestrained animals, and optional automatic detection software.
Parameters Measured: Time spent in each zone, time of zone trespassing, and temperature of each zone.
Specifications: Temperature range from -3°C to +65°C, accuracy of ±0.5°C, and dimensions including cage.

5. Thermal Gradient Test:

Key Features: Continuous thermal gradient over a 120 cm base plate, monitor 2 mice or 1 rat.
Parameters Measured: Up to 20 temperature zones per animal, time spent in each zone, and overall distance travelled.
Specifications: Temperature range from 5 to 55°C, stability of 1°C, and automated system with video tracking.

6. Plantar Test (Hargreaves Apparatus):

Key Features: Automatic detection of paw withdrawal, measurement of hyperalgesia, and modular animal enclosure.
Specifications: Operating temperature from 15° to 30°C, adjustable IR intensity, and universal power requirements.

7. Dynamic Plantar Anesthesiometer:

Key Features: Automatic detection of paw withdrawal, consistent force application, and data portability.
Purpose: Automates assessment of touch sensitivity on the plantar surface of rats or mice.

Certifications: All devices are CE compliant.

References: The document cites various scientific studies related to pain perception, analgesia, and thermal nociception.

Specifications and Features: The document outlines various instruments used for evaluating mechanical pain and inflammation in rodents. Key specifications include:

Dynamic Plantar Anesthesiometer: Measures force range from 0 to 50 grams with adjustable force increase rate. It connects to a PC via a DeLta 9-pin connector.
Electronic Von Frey: Measures mechanical allodynia with a range of 0 to 500 grams. It features internal statistical computations and is available with embedded video options.
Paw & Tail Pressure Meter: Utilizes the Randall & Selitto test to measure pain thresholds with a digital display and adjustable pressure rates.
Digital Water Plethysmometer: Measures small volume changes in paw volume with a resolution of 0.01 ml, useful for assessing inflammatory responses.

Procedures and Usage: Each instrument is designed for specific tests:

The Dynamic Plantar Anesthesiometer and Electronic Von Frey are used to determine pain sensitivity thresholds by applying force to the animal's paw.
The Paw & Tail Pressure Meter applies increasing pressure to measure pain response thresholds.
The Digital Water Plethysmometer measures volume displacement to assess inflammation.

Ordering Information: Each product is listed with model numbers and components included, such as disposable tips, footswitches, and carrying cases. Options for additional software and adapters are available.

Relevance and Applications: The instruments are crucial for research in analgesia and inflammation, providing precise measurements and data recording capabilities. They are used in various studies to evaluate the efficacy of analgesic and anti-inflammatory treatments.

Dynamic Weight Bearing Test: This test features a floor-instrumented cage allowing independent measurement of weight borne by each limb of a freely moving animal. Key parameters measured include weight and surface area for each paw, variability, and duration of different postures. The system includes an animal cage, sensor, USB interface, webcam, and software. Specifications vary for mice and rats, with specific dimensions, weight, and sensor accuracy detailed.

Incapacitance Meter: This test assesses spontaneous pain in animals with inflammation or nerve injury. It uses a touchscreen interface to measure weight distribution on two separate sensors, indicating postural equilibrium or imbalance due to injury. Specifications include a resolution of 0.05 grams and a control unit with dimensions of 17 x 25 x 10 cm.

Social Interaction Test: This test evaluates social behavior by allowing an experimental subject to explore an unfamiliar congener. The social box is divided into three compartments with sliding doors and grid enclosures for interaction. Specifications include dimensions of 42 x 60 x 22 cm for the box and 20 x 42 x 22 cm for each compartment.

Circular Pool for Learning & Memory: The Morris Water Maze is used for spatial working memory studies. The pool is made of polypropylene and includes a water pump, heater, and control box to maintain water temperature. Specifications include heater intensity of 3000 W and temperature range of 22-32°C.

Barnes Maze: This test assesses spatial learning and memory using a round platform with peripheral holes. The goal is for the animal to locate a dark box using visuo-spatial cues. Specifications include platform diameter and height, with options for mice and rats.

T-Y Maze: Used for assessing spatial working memory, the T-Y maze is made of non-reflective, odor-resistant material. Specifications include dimensions for both mice and rat mazes, with manually removable doors for the Y-maze.

Overview: The document provides detailed information on various maze systems and software used for evaluating learning, memory, and attention in laboratory animals, specifically rats and mice. It includes specifications, features, and ordering information for different maze models and associated software.

Maze Systems:

T-Y Mazes: Used for evaluating learning and memory. They offer automated standard experiments with options for manual or automated door control and animal detection via photoelectric cells or video tracking.
Radial Mazes: Available in manual, semi-automated, and automated versions. They are used for evaluating working and reference memory. The maze consists of a central area with eight arms, and the doors can be controlled manually or automatically using the maZeSoft-8 software.
Habitest Runways & Hubs: These are modular and flexible, allowing for various configurations and the addition of stimulus-response modules. They are used in conjunction with radial arm mazes, T-mazes, and Y-mazes.

Software:

maZeSoft-8: A comprehensive software for monitoring radial maze experiments. It allows for manual or automatic control of maze doors and provides detailed data on animal behavior, including memory errors and response latency. Data can be exported to Excel for further analysis.
Graphic State Notation 4 Software: Used for control and data acquisition in conjunction with the Habitest system.

Key Features:

Automated and manual control options for maze doors.
Integrated parameters for detailed analysis of animal behavior.
Data export capabilities for further analysis.
Modular design for flexibility and reconfiguration.

Specifications:

Radial Maze Dimensions: Rat - 1690 x 1690 x 1250/1450 mm; Mouse - 867 x 867 x 1250/1450 mm.
Material Composition: Methacrylate, aluminum, stainless steel.
Power Requirement: 110/220 Vac, 50/60 Hz.

Ordering Information: The document provides specific order numbers and models for various maze systems and software, including options for customization and additional accessories.

References: The document cites several studies that have utilized these maze systems for research on learning, memory, and behavior in rats.

Overview: The document provides detailed information on modular shuttle cages and the StartFear Combined System, both designed for animal behavioral experiments, particularly focusing on learning, memory, and attention studies.

Shuttle Cages:

Designed for both mice and rats, these cages are modular and can be expanded for various applications beyond active and passive avoidance.
Features include photocell sensor systems for animal transit detection, optional guillotine doors, and easily removable floors and drop pans for cleaning.
Ordering information includes various models and accessories such as isolation cubicles, shockers, and blank panel sets.

StartFear Combined System:

This system is versatile for conducting fear conditioning and startle reflex experiments in a single enclosure for both mice and rats.
Key features include weight transducer sensitivity, USB connectivity, and various spatial context configurations for fear conditioning paradigms.
Parameters measured include freezing and startle responses, with detailed data on duration, amplitude, and latency.
Components include an experimental chamber, soundproof box, load cell amplifier, and station interface.

FreezeFrame Software:

A video-based system for fear conditioning, FreezeFrame combines human observer sensitivity with automation for precise movement detection.
It is capable of measuring minute movements and is validated with high concordance with human observers.
Features include motion detection algorithms, low-light performance, and the ability to store and export data for analysis.

Specifications and Ordering:

Detailed specifications for the StartFear system include chamber dimensions, material composition, and sound frequency capabilities.
Ordering information lists various models and accessories, including shock generators and contextual kits for fear conditioning.

References: The document cites numerous studies and references related to fear conditioning and startle response research, highlighting the scientific basis and applications of the systems described.

5/9 Hole Box for Attention Performance: The 5/9 Hole Box is designed for evaluating attention performance in laboratory animals. It features black aluminum walls, a transparent front door, and nine apertures with adjustable LED lights. The box includes a food pellet dispenser and a nose-poke detector. It is compatible with Packwin V2.0 software for experiment control and data collection, measuring parameters such as correct and incorrect responses, omissions, and response latency. The box is available for both rats and mice, with specific configurations for each.

Elevated Plus Maze & Elevated Zero Maze: These mazes are used to assess anxiety-like behavior in rodents. The Elevated Plus Maze has two open and two closed arms, exploiting rodents' fear of open spaces. The Elevated Zero Maze offers a continuous circular path without a central zone. Both mazes are compatible with video tracking systems and are available in various sizes for rats and mice.

Open Field Box: The Open Field Box is used to evaluate basal activity and responses to novel environments in rodents. It is available in square and circular designs, with high walls and non-reflective colors for video tracking. The box is easy to clean and can be customized for specific research needs.

Aron Test for Screening Anxiolytic Substances: The Aron Test, or Four Plates Test, is an anxiety model where exploration is suppressed by mild electric shocks. It measures the number of punished crossings, with anxiolytic substances increasing these crossings. The test apparatus includes a shocker unit and is made of durable materials.

Black & White Test: This test evaluates anxiety by measuring an animal's movement between contrastingly lit compartments. The box is made of perspex with separate illumination for each compartment. It can be equipped with weight transducers and photocell beams for automated detection and analysis.

Vogel Test: The Vogel Test screens potential anxiolytic properties by measuring the number of licks and shocks received in an animal's home cage. It includes a LinkBox interface and can be controlled with Packwin software, supporting up to 32 cages.

Overview: This document provides detailed information on various experimental setups and equipment used in behavioral studies related to anxiety, depression, and addiction in rodents. It includes specifications, ordering information, and key features of each system.

Vogel Test: The Vogel test is designed to assess the anxiolytic properties of drugs by punishing drinking behavior with mild shocks, leading to reduced water consumption. The setup includes a home cage with a grid floor and a special nipple for detecting drinking behavior. The system can handle up to 32 cages, interconnected via RS-232 serial communication. Key specifications include the LE3208 internal memory for up to 99 trials and the LE10025 shock generator with adjustable intensity and duration.

Immobilization Board: This board is used for inducing psychological stress in rodents through forced immobilization. It features a central board with movable arms for paw fixation and a Velcro ribbon for securing the rodent's body. The design aims to optimize restraint procedures, reduce physical stress, and enhance the quality of psychological stress.

Forced Swimming Test: The forced swimming test is a model for testing depression, where rodents are placed in a transparent cylinder and observed for immobility, which is considered a depressive-like behavior. The test is used to evaluate the effects of antidepressants.

Tail Suspension Test: This test screens the psychotropic properties of drugs by measuring the energy expended by mice trying to escape suspension. It includes features like automatic measurement of immobility, video recording options, and direct exportation of results into Excel.

Place Preference Box: The Place Preference Box is used for assessing conditioned place preference and aversion in rodents. It features compartments with different visual and tactile cues and allows for automated data storage and analysis. The system can connect up to 8 stations to a PC.

Spatial Place Preference Box: This box is designed to optimize place preference and aversion studies by incorporating visual, tactile, and spatial cues. It allows for a variety of configurations and can be used with video-tracking systems for detailed analysis.

Conclusion: The document provides comprehensive details on the equipment and methodologies used in behavioral studies, highlighting their applications in research on anxiety, depression, and addiction.

Overview: This document provides detailed information on various systems and software designed for laboratory experiments related to reward, addiction, and metabolism studies in animals. It includes descriptions of the PPCWIN software for conditioned place preference tests, the Self Administration Box for studying addiction, and the OxyletPro System for metabolic studies.

PPCWIN Software:

Designed for conditioned place preference and black and white experiments.
Features include real-time visualization of animal position, integrated results, and easy data export to Excel.
Measures parameters such as total entries into compartments, permanence time, and latency to first transition.
Includes software installation, USB license key, cables, connectors, and a digital instruction manual.

Self Administration Box:

Modular experimental enclosure for studying reward and addiction.
Features include a removable waste tray, modular components for self-administration, and compatibility with Packwin software.
Measures parameters like response rate, number of reinforcements, and response patterns.
Includes experimental chamber, instruction manual, cables, connectors, and a 2-year warranty.

OxyletPro System:

Modular system for studying respiratory metabolism, food and drink intake, and activity in laboratory animals.
Features include home cage advantage, high accuracy monitoring, and adaptability for mice and rat models.
Applications include obesity, diabetes, metabolic disorders, and drug screening.
Components include home cage, airtight lids, intake dispensers, and software modules for metabolism studies.

METABOLISM Software:

Offers modules for respiratory metabolism, intake, and activity studies.
Features include data extraction, calculation of physiological parameters, and real-time monitoring.
Allows correlation between food/drink consumption, metabolism, and activity.
Includes software installation, USB license key, cables, connectors, and a digital instruction manual.

Treadmill for Indirect Calorimetry: The OxyletPro system is a modular setup designed for integrating respiratory metabolism measurements with forced exercise training in rodents. It features a treadmill with adjustable speed and slope, and a control unit. Key features include minimal maintenance, easy cleaning, high-performance motor, and silent operation. The system allows for indirect calorimetry measurement for VOmax determination. Specifications include adjustable current range (0 to 2 mA), belt speed (0 to 150 cm/s), and slope (-25° to 25°).

PheComp System for Compulsive Food and Drink Intake: The PheComp system measures food/liquid consumption and motor activity in rodents to assess compulsive behavior. It uses weight transducer technology for precise analysis of meal patterns and registers food and drink wastage. The system is scalable, allowing up to 12 cages to be connected to one computer. It is suitable for various experimental procedures, including testing obese vs. non-obese subjects and screening anti-obesity compounds. Specifications include high accuracy (<0.03 mg) and specific dimensions for mouse and rat home cages.

In Vivo Electrophysiology & Optogenetics: Triangle BioSystems International (TBSI) offers wireless, multiplexed, and tethered recording solutions for neural recording, electrical, and optogenetic stimulation. Key features include precise data transmission, versatile software, and universal compatibility. The MCS wireless in vivo systems provide an all-in-one solution for amplifying, recording, and analyzing data from up to 32 channels. The advanced W2100-System offers additional features like optical stimulation and excellent signal-to-noise ratio.

Catalog excerpts

Behavioral Research Video Tracking Operant Conditioning Circadian Biology Sensory Motor Analgesia Social Interaction Anxiety & Depression Reward & Addiction Food & Drink / Metabolism Learning, Memory & Attention Locomotor Activity & Exploration In Vivo Electrophysiology & Optogenetics divisions of Harvard Bioscience, Inc. Call to receive other Behavioral Regenerative Medicine Electroporation & Electrofusion Animal, Organ & Cell Physiology Electrophysiology & Cell Biology Research Molecular Sample Preparation catalogs of interest Pumps Surgical Tools

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In addition to our high quality research products, we are proud to offer unparalleled pre- and post-sales support. Our technical staff scientists are happy to help answer any questions you may have or assist with system configurations. ► Product Specifications ► Instruction Manuals ► Working Procedures ► Application Sheets Coulbourn / Harvard Apparatus phone 508.893.8999 • toll free U.S. 800.272.2775 fax 508.429.5732 www.coulboum.com Panlab / Harvard Apparatus Spain +34934190709 • International +34834750697 fax +34934750699 www.panlab.com

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Our products help solve relevant problems in basic and clinical psychopharmacology. Applications include the study of brain functions (cognition, memory, emotion…), the study of related pathologies (Alzheimer’s, Parkinson’s, depression, addiction…) as well as the discovery and screening of new therapeutic compounds. Our goal has always been to offer our customers the best service and full attention which translates into a dynamic business focus, while a constant effort is made to guarantee that high quality standards are accomplished in every detail. The company is constantly renewing and evolving...

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Video Tracking Graphic State® 4 Software pages 16-17 Sensory Motor & Coordination SMART Video Tracking System V3.0 pages 4-7 Analgesia Tru Scan Activity Monitor pages 22-23 Small Animal Treadmills pages 34-35

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Species Guide for Behavioral Systems To help you become more familiar with our product line, we have added small animal icons for every product. These icons will help guide you to which species can be used with each system. Below are the animal icons you will see throughout this catalog.

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Video Tracking SMART Video Tracking System V3.0 Video Tracking • SMART Video Tracking System V3.0 } Flexibility, reliability, productivity and simplicity all } Modular structure to fit all experimental needs, basic and advanced, and budgets } Designed with the latest in both hardware and software technologies, SMART V3.0 represents over 15 years experience for increased functionality and maximum productivity for your experiments

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SMART V3.0 offers the most flexible and easy-to-learn software on the market for the automated evaluation of behavior in the widest range of pre-clinical and neuroscience applications. Utilizing advanced image analysis, SMART V3.0 allows the recording of activities, trajectories, events, social interactions and global activity. SMART V3.0 provides users the versatility of a modular system with the capabilities of a broadband package. Our enhanced data analysis includes customizable data reports and complete calculations for unlimited behavioral paradigms. Developed with the daily experimental...

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SMART Video-Tracking System V3.0 (continued) Video Tracking • SMART Video Tracking System V3.0 Running classic behavior experiments and looking to save time and expense? Opt for our experiment-targeted modules for pre-configured setup and data reports for such tests as water maze (SMART-WM), plus maze (SMART-PM), open field (SMART-OF), place preference (SMART-CPP), forced swim test (SMART-FST), etc. SMART Extensions Our Global Activity Extension - SMART-GA - is ideal for activity related experiments. This option uses frame-to-frame detection for precise monitoring of spontaneous activity and...

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• Information about Subjects, Sessions and Configuration • Tracking calculation in arms, center and total (entries, time, distance covered, speed, resting/slow/fast displacements etc.) • Specific calculations: first arm choice, first arm choice latency, spontaneous alternation triplets, Max Alternation triplet, total arm entries • Time evolution report lists (zone transitions, scored events) • Group evolution graph SMART-CPP (Conditioned Place Preference) • Information about Subjects, Sessions and Configuration • Tracking calculation in drug/placebo related compartment, corridor and total (entries,...

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RECORD-IT! Digital Video Recording Systems Video Tracking • RECORD-IT! Digital Video Recording Systems Ensure traceability ► Systems available for one to 8 cameras ► Record each camera independently as defined by the user ► Generates digital video files that can be processed with standard codecs in a Microsoft® Windows environment (no proprietary format restrictions) ► Independent video files can be generated on-the-fly ► Compatible with our SMART video tracking system, but not exclusive We offer several different options for external digital video recording for ensuring traceability and security...

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Built-in RECORD-IT! BASIC NEEDS Computer Dependency Digital Video Recording / Tracking simultaneous Process of the same Experiment Quality/Price Ratio SMART Built-In/External Solution Digital Video File specifications Image source camera Number & Productivity sMART V2-5, & smart Junior compatibility Other specific Features Video Tracking • RECORD-IT! Digital Video Recording Systems Panlab www.panlab.com iimrniHBiTs

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LimeLight Video Tracking Software Video Tracking • LimeLight Video Tracking Software key features Developed in close collaboration with behavioral neuroscientists ► Flexible and powerful video tracking system ► Ideal for: Open Field, Plus Maze, Zero Maze, Novel Object Recognition, Conditioned Place Preference parameters measured ► Distance travelled in each region (cm or %) ► Time spent in each region (sec or %) ► Crossings into each region ► Body length from nose to base tail (mm), together with stretch-attend bouts ► Pointing direction (orientation) ► Mean distance from center ► Latency to...

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