hydrosun®TWH1500 hyperthermia and irradiation
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Thermography-controlled Water-filtered Infrared-A Superficial Hyperthermia and (Re-)Irradiation New Option for Effective Control of Locally Recurrent Breast Cancer Thermography-controlled Water-filtered lnfrared A superficial Hyperthermia

Locally Recurrent Breast Cancer (LRBC) Although the general therapeutic options and treatment results of breast cancer have remarkably improved, the treatment of locally recurrent breast cancer (LRBC) – especially in cases of pre-irradiation and resistance to chemoand hormone therapy – is still a major problem. Patients suffer from a horrible loss of quality of life (pain, ulceration, bleeding, thoracic constriction, lymphoedema, nerve infiltration). The therapeutic aim is effective local control for improvement of quality of life for longer survival and even cure in cases without...

Hyperthermia & (re-)irradiation In a systematic review, superficial hyperthermia (HT) combined with radiotherapy (RT) in the treatment of LRBC proved efficacy in achieving local control with lower total radiation doses: Proven efficacy in LRBC Datta NR, Puric E, Klingbiel D, Gomez S, Bodis S: Hyperthermia and radiation therapy in locoregional recurrent breast cancers: A systematic review and meta-analysis. lnt J Radiat Oncol Biol Phys. 2016 Apr 1;94(5):1073-87. In randomized controlled studies (RCT) the CR rate in the combined RT/HT group was significantly higher than in the RT group alone...

Thermography-controlled Water-filtered lnfrared A superficial Hyperthermia The world-first device for effective contact-free superficial hyperthermia High Efficacy and Extremely Low Toxicity even for the treatment of large-sized and inflammatory lesions Water-filtered lnfrared A (wlRA) with a high and most compliant energy input Covering large treatment areas independant of heterogenous body contours Continous real-time thermographic control with automatic switch on and off control functions allowing an optimal and safe energy input, achieving an effective heating depth (>39°C) of at least...

A computer-controlled feedback system registers the detailed temperature distribution of the treated skin area, whereby a ROI can be defined. The programme provides a real-time control of the wlRA radiation unit by switching off and on in a defined range of maximum temperature (42°C - 43°C). Treatment data will be documented and stored. Visual inspections of the colour-coded temperature images could be additionally used to guide the correct adjustment of the wlRA-radiator position and to avoid the potential occurrence of hotspots. Hotspots chiefly occurring in scar tissue with poor...

wlRA Hyperthermia + Hypofractionated re-irradiation From September 2009 on, heavily pre-irradiated patients with LRBC have been treated using a new treatment schedule with high efficacy and extremely low radiotherapy- and hyperthermia-related toxicity. Results till 07/2015 resp. 09/2019 are published in: Clinical Results Thermography-controlled wlRA superficial Hyperthermia 45 - 60 min. Hypofractionated (re-)irradiation 1 x/week à 4Gy Total dose: 5 x 4 Gy = 20 Gy High efficacy Complete remission (CR) Partial remission (PR) No change (NC) Progressive disease (PD) Local control after CR Local...

Clinical Results Extended recurrent breast cancer: Former RT-dose chest wall 50 Gy + 10 Gy boost scar Before re-RT & wlRA 6 weeks after 5 x 4 Gy + wIRA, 1x/wk Recurrent breast cancer en cuirasse: former RT-dose both chest walls: 54 Gy Before re-RT & wlRA 6 weeks after 5 x 4 Gy + wIRA, 1x/wk 1st recurrence: 54 Gy + 9 x MW-hyperthermia. 2nd recurrence 4 months later. Before re-RT & wlRA 6 weeks after 5 x 4 Gy + wIRA, 1x/wk Low toxicity Acute toxicity occurred in 43% of the patients and was mostly limited to grade 1, few cases of grade 2, no cases of ≥ Grade 3. Thermal skin damage (Grade 2)...

hydrosun® TWH1500 is developed and manufactured by Hydrosun Medizintechnik GmbH, Müllheim/Germany, a pioneer and world market leader in water-filtered infrared-A technique. heckel is the exclusive distributor for the superficial hyperthermia device hydrosun® TWH1500 and the whole-body hyperthermia device heckel-HT3000. hydrosun medizintechnik GmbH Mauchener Strasse 14 79379 Müllheim / Germany www.heckel-hyperthermia.com info@heckel-hyperthermia.com © Image page 2: Alexander Raths/Shutterstock.com, Image page 5: TWH1500 at Ordensklinikum Linz / Austria Hydrosun has a certified Full Quality...