Brochure-SmartBone-Ortho.
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THE NEXT FRONTIER OF BONE REGENERATION

UNIQUE technology... THE NEXT FRONTIER OF BONE REGENERATION IBI is an innovative hi-tech Swiss biomedical company focused on research, development and production of medical devices for tissue engineering and regenerative medicine: substitutes, grafts, 3D matrixes and 2D scaffolds. IBI believes that regenerative medicine and tissue engineering represent the future in healthcare. IBI has advanced competencies and core skills in processing materials for biomedical applications, which are used to develop proprietary technologies to build new and innovative products. IBI commits to safety and...

ORTHO KEY FEATURES SmartBone® ORTHO is a new hybrid bioactive bone substitutes specifically developed for bone regeneration in reconstructive surgery. SmartBone® ORTHO is suitable for orthopaedic indications such as, traumatology, oncology and spine surgery. SmartBone® ORTHO is produced by combining a bovine mineral bone matrix with resorbable polymers and collagen fragments. This new concept of composite biomaterial promotes a quick growth of the patient’s cells into SmartBone® ORTHO while the biopolymers degrade, providing perfect integration and osteogenesis, allowing a final complete...

ORTHO OPEN AND INTERCONNECTED POROSITY The microstructure of SmartBone® ORTHO’s composite matrix strongly resembles the human bone in terms of open, interconnected and mid-sized porosity. 100µm SmartBone® ORTHO SmartBone® ORTHO 3D render of SmartBone® ORTHO SmartBone® ORTHO is completely resorbed and replaced by the patient’s own bone within 1-2 years: this excellent outcome grants a vital, functional bone-implant integration. SmartBone® ORTHO is extremely biocompatible and is fully compliant with ISO 10993-1 requirements. FROM GRANULES TO BLOCKS AND SPECIAL SHAPES ADVANTAGES OF SMARTBONE®...

ORTHO SMARTBONE® ORTHO MECHANICAL PROPERTIES Full characterization from a torsional, flexural and compression point of view, have been run on SmartBone® ORTHO showing excellent mechanical response under each of these tests. Results are reported in the following Table. Compression Bending Torsion HIGH MECHANICAL PERFORMANCES HIGH HYDROPHILICITY HIGH TISSUE INTEGRATION SmartBone® ORTHO bears 3 times the competitor’s maximum load and is 4 times more rigid. Thanks to its microcomposition, SmartBone® ORTHO quickly reaches an average 38% w/w blood swelling, thereby allowing a robust...

ORTHO CLINICAL CASES Removal of a calcaneus cist. SmartBone® ORTHO Granules and Block. CT Scan of the initial situation. 0 Months: Post operative X-Ray. 5 Months: Good bone regeneration. 5 1/2 Months: Good bone regeneration. 6 Months: Excellent clinical condition good bone remodelling. Courtesy of Dott. M. Spezia A decomposed multifragmentary fracture of the distal diaphysis region of the fibula and a decomposed multifragmentary joint fracture of the distal diaphise-epiphyseal region of the tibia. SmartBone® ORTHO Granules and Block Rx of the initial situation: fibula and tibial fractures....

ORTHO Plurifragmentary fracture of the radial epiphysis and detachment of the ulnar styloid. CT Scan of the multifragmentary radial distal epiphysis facture. 1 Month: Follow-up after cast removal. Olecranon multifragmented fracture. 0 Months: Follow-up immediately after op with fixation device (plates, screws, figure of 8 cerclage wire with pins). 1 Month: Follow-up of multiple fracture of the olecranon and humeri capitulum fracture synthesized. Corrective tibial osteotomy opening. 0 Months: Post operative X-Ray tibial osteotomy Pre-op situation with ABC in posterior acetabular and iliac...

ORTHO SPINAL CLINICAL CASES Vertebrectomy for osteoblastoma T2. SmartBone® ORTHO Block. CT Scan of the initial situation: osteoblastoma T2. 0 Months: Post operative X-Ray after bone replacement with fixation devices. 6 Months: Good osteointegration. 1 Year: Good integration of Block in the vertebrectomy. 1 Year: Evidencing good integration and ongoing bone remodelling. Courtesy of Dott. A. Gasbarrini SmartBone® ORTHO Block. CT Scan of the intitial situation: osteoblastoma L4 0 Months: Post operative X-Ray with a fixation devices. 1 Month: Good osteointegration. 8 Months: Good integration of...

CUSTOM MADE GRAFTS FOR RECONSTRUCTIVE SURGERY ARE ONLY FOUR STEPS AWAY Diagnosis prescription Digital planning Custom made bone graft The surgeon sends the patient’s CT Scan in .dicom format with a brief clinical description. IBI designs the graft in accordance with the surgeon’s clinical prescriptions. IBI produces the custom made graft in the .stl format file. 3 weeks later you the graft is shipped ready for the surgical operation. No sterilization or extra shaping required. SMARTBONE® ON DEMANDTM ORTHO • helps you to resolve complex situations; • is a custom-made bone graft specifically...

ORTHO CATALOGUE Our most used shapes are available in the following sizes (for other shapes please check our product catalogue as they are available only on request): ORTHO ITEM ORTHO ITEM ORTHO ITEM ORTHO ITEM marked Class III Medical Device

ORTHO FAQs • What is SmartBone® ORTHO made of? It’s a composite material, made of a bovine derived mineral matrix, reinforced with biopolymers and proteins (collagen fragments of porcine origin). Which biopolymers are used? We use biodegradable polymers, namely aliphatic polyesters, the same used e.g. in resorbable sutures. What’s the biological mechanism of osteointegration of a bone graft? SmartBone® ORTHO as any other bone substitute for that matter, works as a template for bone ingrowth, where the scaffolds of the exogenous bone guide the newly produced bone. As native bone grows, it...

Industrie Biomediche Insubri SA Via Cantonale, 67 Mezzovico-Vira CH-6805 Switzerland Ph. +41 91 93 06 640 www.ibi-sa.com info@ibi-sa.com CAUTION: The law restricts the sales of these devices made by, or on the order of, a surgeon. Warning: Possible complications that can occur in any surgery might include: swelling of the operative site, intrarticular mobilization, local inflammation, bone loss, infection, pain, lack or incomplete osteointegration, partial or complete graft resorption and/or loss of mechanical performances of graft. This brochure is for healthcare professionals only,...