for Digital Breast Tomosynthesis Challenge Digital breast tomosynthesis (DBT) is rapidly replacing full-field digital mammography in screening due to its clinical value in cancer detection. Although this advanced technology is becoming the standard of care, it presents significant challenges to radiologists. Clinicians are confronted by the workload and time required to accurately read the extensive amounts of data contained in DBT cases. Further, as incidence rates of cancer continue to rise, it is becoming increasingly more important to find cancer sooner, while reducing unnecessary recalls resulting from false positives. Solution ProFound AI™ for digital breast tomosynthesis is revolutionizing the DBT reading paradigm and presents a transformative solution to address these challenges. The high-performing, concurrent-read, cancer detection and workflow solution rapidly and accurately analyzes each tomosynthesis image, detecting both malignant soft tissue densities and calcifications with unrivaled accuracy. Built on the latest deep learning and artificial intelligence (AI) technology, ProFound AI is clinically proven to assist radiologists in addressing the challenges of reading tomosynthesis cases by: • Improving cancer detection rates • Reducing false positives and unnecessary patient recalls • Decreasing reading times Clinical Performance Benefits Workflow Benefits • 8.0% average increase in sensitivity • 52.7% reduction in reading time • 6.9% average increase in specificity • Certainty of Findings scores assist in prioritizing caseload and clinical decision-making • 7.2% average reduction in recalls • 5.7% average improvement in radiologist AUC Compatible with leading digital breast tomosynthesis systems Breast Health Solutions 1.866.280.2239 toll free | 1.603.882.5200 | [email protected] | www.icadm

Certainty of Finding and Case Scores The ProFound AI algorithm is trained to detect malignant soft tissue densities and calcifications. Certainty of Finding and Case Scores are assigned to each detection and each case respectively. Certainty of Finding and Case Scores are relative scores computed by the ProFound AI algorithm and represent the algorithm’s confidence that a detection or case is malignant. The scores are represented on a 0% to 100% scale. A higher score indicates a higher level of confidence in the malignancy of the detection or case. The scores are calibrated to a population of...