Bone Graft Substitute Product Overview Inion BioRestore™

Inion BioRestore™ Introduction Inion BioRestore™ is a synthetic bone graft This apatite layer provides scaffolding onto which substitute, which remodels into bone and is the patient’s new bone will grow allowing repair easy to use. Inion BioRestore™ is made from of the defect. Inion BioRestore™ is gradually degradable bioactive glass which once in contact resorbed and replaced by new bone during with the natural body fluids forms a silica gel the healing process, this process is estimated and calcium phosphate layer which provides to take 6 months in vivo (based on preclinical scaffolding for...

Inion BioRestore™ works by osteostimulation which is defined Scaffolds are composed of fibres which are welded together as the active stimulation of osteoblast proliferation and to form an interconnected, fully open three dimensional structure differentiation.* As shown during in vitro studies by increased that allows for the bone cells to weave between the scaffold and levels of alkaline phosphatase, Inion BioRestore™ supports lay down a solid matrix of new bone tissue. How Inion BioRestore™ works? higher osteoblast activity and expression and acts as a scaffold around and through which new...

The modified surface of the Inion BioRestore™ immediately In a continuing chemical reaction occurring over the next few begins to interact with the bodies own proteins, cells and days, a temporary scaffold of hydroxyapatite crystals forms on the growth factors for tissue regeneration. surface of the Inion BioRestore™ particles which traps and bonds these building blocks to create a bed for new tissue growth. Scaffold material Scaffold material Bony tissue formation Bony tissue formation Bony tissue a degraded fibre inside formation Bony tissue formation inside the 3D structure inside a degraded...

Advantages of Inion BioRestore™ Comparison of synthetic HA, TCP and Inion BioRestore™ as bone graft substitutes HA Bioactive Glass Physical Form Porous/bulk blocks and granules. Porous blocks, morsels and granules. Bulk blocks and granules Basic Mechanism Serves as osteoconductive surface. Serves as osteoconductive surface. Forms chemical bonding with ongrowing new bone. Osteostimulative in addition to osteoconductive. Molecular Mechanism of Action In Vivo Induce high local bone turnover. Material dependent. Material dependent. Tailored by varying composition. Resorption Rate Slowly / very slowly...

Choose appropriate Inion BioRestore™ product. Preoperative radiographic evaluation of the defect site is essential to accurately assess the extent of the defect and to aid in the selection and placement of the graft material. The Inion BioRestore™ should be wet with patient’s blood or marrow, or sterile saline or water before application. While the Inion BioRestore™ can be moistened with either sterile saline or water, osseous regeneration may occur more rapidly by using the patient’s osteogenic blood or marrow obtained by scoring the surface or drilling into the cortical bone at the surgical...

INION OY Lääkärinkatu 2 FI-33520 Tampere, FINLAND tel: +358-10-830 6600 fax: +358-10-830 6601 email: [email protected] internet: www.inion.com INION INC 2800 Glades Circle Suite 138, Weston FL 33327 USA Toll-free tel: 866-INION-US tel: 954-659-9224 fax: 954-659-7997