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BoneCeramic™ - 1

BoneCeramic™ Data Sheet More than a synthetic solution. Straumann® BoneCeramic™ is a biocompatible and homogenous alloplast designed to maintain volume while supporting gradual replacement by your patient’s own bone. A fully alloplastic biphasic calcium phosphate, it’s composed of hydroxylapatite, which prevents excessive resorption and preserves bone volume, and ß-tricalcium phosphate, which absorbs more quickly as it’s replaced by natural bone. EFFECTIVE REGENERATION MATERIAL • ngineered to support restoration and preservation E of bone volume • Gradually resorbs as it is replaced by new vital bone DEPENDABLE PERFORMANCE • xcellent handling characteristics E FLEXIBILITY TO MEET CLINICAL NEEDS • an be used alone or in combination with C autogenous bone • Best suited for peri-implant dehiscence defects, fenestration defects, sinus lifts, extraction sockets, and horizontal augmentations SUPPORTS ONGOING BONE REGENERATION • 8.35 % average newly formed mineralized bone 2 versus 22.27 % with bovine bone mineral, 6 to 8 months post augmentation (p = 0.6024)1 • Trend of increase in mineral bone formation over healing time1 Image by Prof. Dr. S.J. Froum. Stevenel´s blue and Van Gieson´s picro fuchsin, magnification X 200. Reproduction authorized by International Journal of Periodontics & Restorative Dentistry. NMB: New mineralized bone SBC: Straumann BoneCeramic Polarized image displays osseointegration of Straumann BoneCeramic particle in lamellar type of bone, 6 months post augmentation Image by Prof. Dr. Z. Artzi. Paragon staining, original magnification X 600. Reproduction authorized by Clin. Oral Impl. Res. % 50 45 Percentage of augmented area • Consistent and reproducible quality because it’s totally synthetic Bone Particles Mean bone area fraction, post augmentation (Artzi Z et al.) • Bone vitality was 100% in all cores harvested1 • Significant increase in mean bone area fraction over healing time in a mix with autogenous bone, in sinus floor elevation2 Froum SJ et al. Histomorphometric comparison of a biphasic bone ceramic to anorganic bovine bone for sinus augmentation: 6- to 8- month postsurgical assessment of vital bone formation. A pilot study. Int J Periodontics Restorative Dent. 2008 Jun; 28(3): 273-81. Artzi Z et al. Histomorphometric assessment of bone formation in sinus augmentation utilizing a combination of autogenous and hydroxyapatite/biphasic tricalcium phosphate graft materials: at 6 and 9 months in humans. Clin. Oral Implants Res

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BoneCeramic™ - 2

Radiograph shows pneumatized sinus Initial clinical situation Flap elevated, alveolar ridge visible and insufficient bone height for implant placement Window technique used to access the sinus floor Straumann BoneCeramic wetted with patient's blood BoneCeramic packed to the sinus through the opened window Radiograph shows the elevated floor after sinus floor elevation with BoneCeramic International Headquarters Institut Straumann AG Peter Merian-Weg 12 CH-4002 Basel, Switzerland Phone: +41 (0)61 965 11 11 Straumann North American Headquarters Straumann USA, LLC

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