Experience predictability CADENCE is designed for predictable procedures with Streamlined instrumentation Advanced anatomic design

CADENCE◊ is designed for predictable procedures Designed for efficiency in the OR through: Reproducible implant alignment Repeatable talar preparation due to instruments with fluoroscopic cues with pins that set the location of multiple guides Tibia resection Talar resection Intuitive tray and instrument layout to facilitate procedure flow as compared to reported OR times2,3 of Wright Medical Infinity® and InBone® with Prophecy® P

Designed for optimal fit through: Anatomic tibial baseplate Anatomic talar implant with fibular sulcus with conical axis of rotation available in chamfer and flat cut designs Biased poly options Customizable implant combinations to address sagittal deformities to treat a variety of patient anatomies* Anterior *Number of available implant combinations varies by country and region

Indications The CADENCE◊ Total Ankle System is designed to treat ankle arthritis through replacement of the ankle joint with a prosthesis, thereby reducing pain, restoring alignment, and allowing for movement at the replaced joint. The CADENCE Total Ankle System is indicated for use to treat: • Systemic arthritis of the ankle (e.g. rheumatoid arthritis, hemochromatosis) • Primary arthritis (e.g. degenerative disease) • Secondary arthritis (e.g. post-traumatic, avascular necrosis, if minimally 2/3 of the talus is preserved) CADENCE Total Ankle System is also indicated for revision surgeries following...