West Penn Hospital Burn Center OBJECTIVE Research suggests that Active Leptospermum Honey’ (ALH) improves outcomes in patients with partial thickness burns by enhancing the healing and re-epithehalization rate and and producing favorable clinical outcomes.' 3 This prospectively planned pilot study was IRB approved and designed to establish preliminary results for effectiveness and to inform for future large scale clinical trials. This case series study assesses the effectiveness of ALH Gel on time-to-heal, bacterial growth in the wound, patient satisfaction, and cost of treatment in patients with partial thickness facial bums. Two patients with thermal burn injuries treated with ALH at initial presentation, mid-treatment, and at study completion. METHODS Seven patients (ages 7-64) with partial thickness facial burns were recruited from a northeastern U.S. burn center. Dressing changes with ALH, wound photography, and tests for the presence of exudate were performed daily. Bacterial growth was assessed via wound cultures on days 1 and 7 (+/- 2 days). Three physicians independently reviewed the daily photographs which were presented in a randomized order to minimize bias; they then assigned standardized ratings of wound healing. Patients completed a satisfaction survey at the end of treatment, and cost of treatment was calculated. Figure 1. Physician Rating of Wound Status - Week 1 RESULTS Time-to-heal ranged from three to 14 days (mean 8.1 days). Wound cultures revealed normal bacterial growth on days 1 and 7 for all patients. Patients rated ALH gel favorably, with the most common complaint of stickiness in five patients. One patient expenenced transient burning on application that did not interrupt treatment. Averago cost of treatment was S61.55 per patient. Table 1. Enrollment Criteria Table 2. Individual Patient Characteristics and Outcomes ID Gender Age Burn Type Total TBSA Face TBSA Co-Morbidities ^ay"^1 CONCLUSION Healing time was congruent with or better than what would have been expected with standard treatment using antimicrobial ointment. Further, despite no oral or iv antibiotic treatment, during the study time frame, wound cultures showed no abnormal bacterial growth. Finally, patients overall reported satisfaction with treatment. Our findings suggest that ALH is a clinically and economically valuable treatment for partial thickness facial burns. References: 1 Mobn.PC Th; tritencemd Ibtratuculefct tf* use Of toney asa iwurtidre-sitg. 1 ;19|41:204*220.2 Bar$€. toteetn. W. terryEJ.CtrfcrOA.The iruajaiardteclenai Kdiityd rehoney:OTbactErtalmctrnu r&ei&ot and trarar plim* aroff sis; fur J CIn MfcrolM totef to 0|:1199-206.3. Getrge MM. totting KF. tatty IMEDWCWET* h- /iro actvcy agaM dntcal isolates ot MRSA VP£ sr<J rmwr r<jitr&st3tir< gra/n-rKgatve organsrs ndudng toucfcnwws Mtonctt UEOMMY*ActM UyftupcnmmHonty Unsung OftraSomkc* he. Fttrcetm HJ Dvrra Sowcw pxwtted an tduatttfu! o'»ilto sspfol his rweafiii. The bftnwtcn rrcf/ ircfctte a use thU tus rut been Cf (Jeered fc* tte FcaJ aid Ch-fl Mnnfetatfon. Ths rlirra^m cs r>:4 teng irwrW cn Beta! of Denra Soemes.