Whole-body plethysmography System The whole-body plethysmography (WBP) system allows for the measurement of lung function and airway response in awake, freely moving animals. It avoids the effects of invasive tracheotomy and anesthesia, making the procedure easy and fast, and is suitable for long-term follow-up studies. The animal is placed in whole-body plethysmograph, which is connected to a highly sensitive sensor. When the animal breathes, volume of the body tracing chamber. The volume change is converted into electrical signal by pressure transducer and amplifier, computer screen after processing....

• No anesthesia, No surgery, Free moving. • Anesthesia and surgery can affect the animal's spontaneous breathing. • Animals are in awake and free-moving state during measurement, this allows for long-term follow-up studies, suitable for initial drug screening Acquire the real data • Non-invasive method can obtain the respiratory rate, tidal volume and minute ventilation under the real spontaneous breathing. The invasive mode is the animals applied by mechanical ventilation after anesthesia surgery, so the a b o v e p a r a m e t e r s c a n n o t b e o b t a i n e d accurately. High throughput...

- Breath Frequency - Tidal Volume - Respiratory Flow - Minute Ventilation - Inspiratory Time - Expiratory Time - Peak Inspiratory Flow Rate - Peak Expiratory Flow Rate - Relaxation Time - Accumulated Volume - Other Parameters Cough detection

Whole-body plethysmography System Morphine withdrawal Safety Pharmacology COPD Cough Pulmonary Fibrosis

The system can be extended to connect with a nebulizer to administer drug to the animals, this is generally used in cough and asthma studies. WBP system can detect and record the respiratory parameters and airway hyperresponsiveness during excitation. The WBP system can detect and record the changes of respiratory indexes and airway hyper-responsiveness during the excitation process, which can be used to evaluate the broncho-constriction, etc. Easy Setup Automatic calibration Complete calibration operations in 1 minute. Powerful analytical capabilities, the software can perform both single-wave...

Whole-body plethysmography System Optional Plethysmographs With water bottles and food trough, available for long-term continuous monitoring Electrophysiology plethysmograph, for combined with optogenetic technology, EEG, EMG,etc. NHP(non-human primate) plethysmograph Rabbit, dog, ferret plethysmograph Model Selection

Whole-body plethysmography System Inhalation toxicology studies Combined with optogenetic technology, EEG, EMG,etc. Simultaneous monitoring of animal activity and respiratory Infrared thermal imaging for shell temperature

Whole-body plethysmography System Synchronized video recording Telemetry system: Core temperature, ECG, EEG, etc. Continuous drug administration, blood collection and microdialysis *Customization is accepted according to customer experiment requirements

• Sun Lingna, Fan Mingrui, Huang Dong, Li Bingqin, Xu Ruoting, Gao Feng, Chen Yanzuo. "Clodronate-loaded liposomal and fibroblast-derived exosomal hybrid system for enhanced drug delivery to pulmonary fibrosis" [J]. Biomaterials, 2021 • Jiang C, Huang H, Yang X, et al. Targeting mitochondrial dynamics of morphine-responsive dopaminergic neurons ameliorates opiate withdrawal[J]. The Journal of Clinical Investigation, 2024. • Jinru Zhang, Keqin Ji, Yuanmeng Ning, Lingna Sun, Mingrui Fan, Chunjie Shu, Ziqi Zhang, Tianyu Tu, Jingyun Cao, Feng Gao, and Yanzuo Chen. Biological Hyperthermia-Inducing...