INTEGRATED METHOD

Product catalog summary

Introduction
The document outlines an integrated method for the treatment and management of complex skin lesions, such as chronic ulcers, traumas, and burns. This method involves the use of specific devices and therapies to effectively manage different therapeutic phases.

Specifications

GENERA UDD (Ultrasonic Debridement Device): This device is used for the cleansing and ultrasonic debridement of lesions. It removes necrotic-fibrinous material and significantly reduces bacterial load, preparing the ulcerative bed for grafts and medical treatments.
GENIX IT (Collagen Infusion Therapy): This therapy involves the application of a collagen membrane equipped with an infusion catheter to stimulate granulation tissue and manage infections and pain. The collagen is derived from heterologous pericardial or dermal tissue and is absorbable, aimed at dermal regeneration.
GENIX EGI (Epithelial Growth Inducer): This is used for re-epithelialization of lesions. It involves applying a collagen membrane derived from heterologous pericardial tissue to the edges of the lesion to stimulate and accelerate healing.

Procedures
The treatment process involves several phases:

Cleansing and Debridement: Initial cleansing using GENERA UDD to prepare the wound bed.
Granulation and Infection Management: Application of GENIX IT to stimulate granulation and manage infections and pain.
Re-epithelialization: Use of GENIX EGI to promote and accelerate the re-epithelialization process.

Case Studies
The document includes case studies demonstrating the effectiveness of the integrated method:

An 80-year-old patient with an infected post-traumatic skin ulcer showed significant improvement after treatment with GENERA UDD and GENIX IT.
Complete healing was observed in another case after three months of treatment using GENIX EGI.

Conclusion
The integrated method using GENERA UDD, GENIX IT, and GENIX EGI provides a comprehensive approach to managing complex skin lesions, promoting effective healing through a structured therapeutic process.

Catalog excerpts

BIBLIOGRAPHY - Albini A, Adelman-Grill BC. Collagenolytic cleavage products of collagen type I as chemoattractants for human dermal fibroblasts. Eur J Cell Biol 1985 36: 104–7 - Purna SK, Babu M Collagen based dressings – a review. Burns 2000, 26: 54–62 INTEGRATED METHOD treatment and management of complex skin lesions - Ruszczak Z Effect of collagen matrices on dermal wound healing. Adv Drug Delivery Rev 55: 2003,1595–1611 - Rudnik A Advances in tissue engineering and use of type I bovine collagen particles in wound bed preparation. J Wound Care 2006,15: 402–3 - Di Cosmo F Edge effect: the role of collagen in wound healing. Adv Skin Wound Care 2009, 22(suppl 1): 13–16 - Rangaraj A, Harding K, Leaper D. Role of collagen in wound management. Wounds uk, 2011, Vol 7, No 2, 54 – 63 - La Rosa A. Ultrasonic debridement and collagenenic therapy in the management of leg ulcers with a new integrated method. 5th International Workshop on Wound Technology – Paris, January 20-22, 2013, 59 -Sudbeck BD, Parkes WC, Welgus HG, Pentland AP. Collage-stimulated induction of keratinocytes collagenases is mediated via tyrosine kinase and protein kinase C activities. J Biol Chem 1994, 269: 30022– 29 - Veves A, Sheene P, Hau P. A randomised controlled trial of a collagen/ oxidised regenerated cellulose dressing, Promogran, versus standard treatment in the management of diabetic foot ulcers. Arch Surg 2002137: 822–7 - La Rosa A. et al. Ultrasonic Treatment of Infected Leg Ulcers: Results Preliminary. 15th World Congress of Phlebology of the Union Internationale de Phlebologie - Rio de Janeiro, October 2-7, 2005 - Wolcott RD, Kennedy JP, Dowd SE. Regular debridement is the main tool for maintaining a healthy wound bed in most chronic wounds. J Wound Care 2009 18: 54–6 Italia Medica srl - Milano Via V. Monti 77, 20145 Milano - ITALY tel. +39 02 33603560 fax +39 02 33101796 www.italiamedicasrl.com [email protected] - Equine Pericardium Collagen Wound Dressing in the Treatment of the Neuropathic Diabetic Foot Wound. A Pilot Study. John G. Fleischli, DPM, Terese J. Laughlin, DPM and Jeffery W. Fleischli, DPM. Journal of the American Podiatric Medical Association. Volume 99 Number 4301-305 2009 - E. A. O’Toole - Extracellular matrix and keratinocyte migration, Blackwell Science Ltd Clinical and Experimental Dermatology 2001, 26, 525±530

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INTEGRATED METHOD The treatment of complex skin lesions, such as chronic ulcers, traumas and burns, requires effective management of the following therapeutic phases: Cleansing - debridement of the lesions Stimulation of granulation tissue Management of infections and pain Re-epithelialization of the lesions Management of therapeutic phases using: Treatment and management of complex skin lesions GENERA UDD (Ultrasonic Debridement Device) Cleansing - ultrasonic debridement of the lesions, with removal of necrotic-fibrinous material and significant reduction of the bacterial load, is aimed at preparing...

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GENERA UDD
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