BIBLIOGRAPHY - Albini A, Adelman-Grill BC. Collagenolytic cleavage products of collagen type I as chemoattractants for human dermal fibroblasts. Eur J Cell Biol 1985 36: 104–7 - Purna SK, Babu M Collagen based dressings – a review. Burns 2000, 26: 54–62 INTEGRATED METHOD treatment and management of complex skin lesions - Ruszczak Z Effect of collagen matrices on dermal wound healing. Adv Drug Delivery Rev 55: 2003,1595–1611 - Rudnik A Advances in tissue engineering and use of type I bovine collagen particles in wound bed preparation. J Wound Care 2006,15: 402–3 - Di Cosmo F Edge effect: the role of collagen in wound healing. Adv Skin Wound Care 2009, 22(suppl 1): 13–16 - Rangaraj A, Harding K, Leaper D. Role of collagen in wound management. Wounds uk, 2011, Vol 7, No 2, 54 – 63 - La Rosa A. Ultrasonic debridement and collagenenic therapy in the management of leg ulcers with a new integrated method. 5th International Workshop on Wound Technology – Paris, January 20-22, 2013, 59 -Sudbeck BD, Parkes WC, Welgus HG, Pentland AP. Collage-stimulated induction of keratinocytes collagenases is mediated via tyrosine kinase and protein kinase C activities. J Biol Chem 1994, 269: 30022– 29 - Veves A, Sheene P, Hau P. A randomised controlled trial of a collagen/ oxidised regenerated cellulose dressing, Promogran, versus standard treatment in the management of diabetic foot ulcers. Arch Surg 2002137: 822–7 - La Rosa A. et al. Ultrasonic Treatment of Infected Leg Ulcers: Results Preliminary. 15th World Congress of Phlebology of the Union Internationale de Phlebologie - Rio de Janeiro, October 2-7, 2005 - Wolcott RD, Kennedy JP, Dowd SE. Regular debridement is the main tool for maintaining a healthy wound bed in most chronic wounds. J Wound Care 2009 18: 54–6 Italia Medica srl - Milano Via V. Monti 77, 20145 Milano - ITALY tel. +39 02 33603560 fax +39 02 33101796 www.italiamedicasrl.com [email protected] - Equine Pericardium Collagen Wound Dressing in the Treatment of the Neuropathic Diabetic Foot Wound. A Pilot Study. John G. Fleischli, DPM, Terese J. Laughlin, DPM and Jeffery W. Fleischli, DPM. Journal of the American Podiatric Medical Association. Volume 99 Number 4301-305 2009 - E. A. O’Toole - Extracellular matrix and keratinocyte migration, Blackwell Science Ltd Clinical and Experimental Dermatology 2001, 26, 525±530

INTEGRATED METHOD The treatment of complex skin lesions, such as chronic ulcers, traumas and burns, requires effective management of the following therapeutic phases: Cleansing - debridement of the lesions Stimulation of granulation tissue Management of infections and pain Re-epithelialization of the lesions Management of therapeutic phases using: Treatment and management of complex skin lesions GENERA UDD (Ultrasonic Debridement Device) Cleansing - ultrasonic debridement of the lesions, with removal of necrotic-fibrinous material and significant reduction of the bacterial load, is aimed at preparing...