iWorx ZS-200 Zebrafish ECG system
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iWorx ZS-200 Zebrafish ECG system - 1

IWORX ZEBRAFISH ECG In cardiovascular drug discovery, Zebrafish are used to model such processes as thrombosis, collateral vessel development, inflammation, cardiomyopathy, and cardiac regeneration. The iWorx ZS-200 Zebrafish ECG Recording and Analysis System provides an ideal way to use this cost-effective model for high throughput, rapid screening of compounds. The LS-30ECG LabScribe3 ECG Analysis Module provides an array of analysis options including T and QT segment shortening and prolongation which are a key indicator of cardiac function. The ZS-200 provides a compact, easy-to-use and non-invasive solution for investigation of cardiac side effects of a vast number of molecules. Zebrafish ECG Recording and Analysis System Thumb Screw to raise and adjust Electrode contact with fish Fish pedestal

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iWorx ZS-200 Zebrafish ECG system - 2

IWORX ZEBRAFISH ECG The ZS-200 Zebrafish system provides a compact, easy-to-use and non-invasive solution for investigation of cardiac side effects of a vast number of molecules. The system features: ■ Cost-effective, simple method for rapid, consecutive measurements ■ Small footprint increases data flow and helps go/no go decision making System Components The iWorx ZS-200 Zebrafish ECG Recording System consists of: • IX-100F Recorder (5 in. x 4 in. x 2 in.) optimized for recording microvolt ECG signals from Zebrafish. The System has a system noise of about 1 microVolts with the electrodes...

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iWorx ZS-200 Zebrafish ECG system - 3

IWORX ZEBRAFISH ECG • A-ZEC-200 Zebrafish ECG Recording Chamber. The Zebrafish chamber has been optimized for recording ECG from Zebrafish that are between 1" to 2" in length. The chamber (4 in. x 2 in. x 3 in.) consists of the following components: - Aluminum enclosure that is grounded to reduce 60 Hz noise. - Fish pedestal with a machined cavity to make it easy to place the fish on its back. - A thumb screw with a swivel mechanism to position the electrode on the fish. - Replaceable electrode holder with AgAgCl electrodes.Shielded electrode cables used to carry the small ECG signal from...

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iWorx ZS-200 Zebrafish ECG system - 4

IWORX ZEBRAFISH ECG Software LS30-ECG iWorx LabScribe ECG Software Module is a powerful and user-friendly tool intended to automate the analysis of ECG data from a variety of species. Specific analysis templates are included to accurately delineate PQRST onset, durations and amplitudes. Custom templates can also be created based on unique ECG profiles and saved to a library for future use. Other features include beat averaging, beat classification and outlier removal based on abnormal R-R intervals, heart rate, noise and activity, as well as the ability easily extract source data and...

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iWorx ZS-200 Zebrafish ECG system - 5

IWORX ZEBRAFISH ECG Simple, Non-Invasive Protocol Preparing the Chamber: Raise the electrodes and clean them with water. Apply electrode gel to the electrodes. The Zebrafish is placed in a 2-phenoxyethanol anesthetizing solution (1:1000 dilution) for approximately 2-3 minutes until there is minimal gill motion. The pedestal is removed from the chamber. The fish is then positioned on its back on the pedestal. The pedestal is placed in the chamber such that the fish is under the electrodes. The position of the first electrode should be just below the gills of the fish, along the midline. The...

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iWorx ZS-200 Zebrafish ECG system - 6

IWORX ZEBRAFISH ECG Published Citations • Missinato, Maria A., et al. ''Dusp6 attenuates Ras/MAPK signaling to limit zebrafish heart regeneration.” Development145.5 (2018): dev157206. • Dvornikov, Alexey V., et al. ‘‘Phenotyping an adult zebrafish lamp2 cardiomyopathy model identifies mTOR inhibition as a candidate therapy.” Journal of molecular and cellular cardiology (2019). • Liu, Hao, et al. ‘Screening and identification of cardioprotective compounds from Wenxin Keli by activity index approach and in vivo zebrafish model.” Frontiers in Pharmacology 9 (2018): 1288. • Woods, Courtney...

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