T011T012B0C2

T011T012B0C2

T011T012B0C2

Product catalog summary
Product Overview
This document describes the B-raf V600E Gene Mutation Detection Kit, which is used for detecting mutations in the B-raf oncogene, specifically the V600E mutation. This kit aids in the molecular diagnosis of tumors and helps guide individualized clinical treatment plans for cancer patients.
Mutation Frequency
  • Malignant Melanoma: 60% - 80%
  • Thyroid Cancer: 29% - 83%
  • Colorectal Cancer: 6% - 15%
  • Lung Cancer: 1% - 3%
Product Advantages
  • High Sensitivity: Detects B-raf V600E mutations as low as 1%.
  • Strong Specificity: Utilizes dual blocking technology with ARMS primers and blocking probes to increase detection specificity.
  • High Accuracy: Reliable results with reduced false negatives through internal control gene supervision.
  • Easy Operation: Test completion within 3 hours from specimen submission to result.
Clinical Significance
  • Patients with wild-type K-ras gene and B-raf mutations show ineffective treatment with EGFR inhibitors like cetuximab and panitumumab.
  • Panitumumab and Erbitux are effective in patients with wild-type B-raf tumors.
  • B-raf mutation serves as both a predictive and prognostic indicator, with poor prognosis in colorectal cancer patients with this mutation.
Clinical Trial Data
  • Thyroid Cancer Sample: Sensitivity 100%, Specificity 90.91%, Total Coincidence Rate 98.07%
  • Colorectal Cancer Sample: Sensitivity 100%, Specificity 98.19%, Total Coincidence Rate 98.31%
Packing Specifications
12 Tests per Kit
Testing Samples
Applicable to tumor patient’s lesion tissue, including fresh diseased tissue, frozen pathological section, and paraffin-embedded pathological tissue or section.
Contact Information
Jiangsu Mole BioScience Co., Ltd.
Addresses in Hangzhou, Zhejiang, and Taizhou, Jiangsu, China.
Email: [email protected]
Stock code: 839185
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Catalog excerpts

T011T012B0C2-1

B-raf V600E Gene Muta�on Detec�on Kit (Fluorescent Probe-Based Real-Time PCR Assay) ——Auxiliary diagnos�c indicators (DNA) for the individualized treatment plan for cancer pa�ents Product Usage This kit is used for the detec�on of muta�ons in tumor-specific oncogene gene B-raf V600E, and can be used for individualized molecular diagnosis of tumors, thereby guiding individualized clinical treatment plans for tumor pa�ents. Muta�on Frequency of B-raf Gene V600E Colorectal Cancer Lung Cancer Mole Biology reserves the right to modify and interpret the pictures, text and data in this

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T011T012B0C2-2

Product Advantage High Strong Specificity Easy Operation High Accuracy Dual blocking technology by using ARMS primers and blocking probes, effec�vely increasing the specificity of detec�on Comple�ng the test within 3 hours from submi�ng the specimen to ge�ng the result Reliable results and reducing false nega�ve test results through internal control gene supervision Accurate detec�on of B-raf gene V600E site muta�on as low as 1% Clinical Significance Medica�on Guide 1: Pa�ents with wild-type K-ras gene and muta�ons in B-raf gene show ineffec�ve treatment with EGFR inhibitors such as cetuximab and...

 Open the catalog to page 2

Archived catalogs

  1. B052T050B0C2

    2  Pages

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