T021T012B0C2

T021T012B0C2

T021T012B0C2

Product catalog summary
Background Overview
The K-ras gene, located on chromosome 12, is crucial in tumor growth regulation. Mutations in this gene lead to continuous cell growth and cancer by disrupting normal cell signaling and preventing apoptosis.

K-ras Gene Mutation Detection Kit
This kit uses a fluorescent probe-based real-time PCR assay to detect K-ras gene mutations, aiding in personalized cancer treatment plans. It is particularly relevant for colorectal, pancreatic, and lung cancers, with mutation frequencies of approximately 40%, 90%, and 15%, respectively.

Product Advantages
  • Speed: Results are available within 3 hours.
  • Reliability: Internal control gene supervision reduces false negatives.
  • Specificity: The amplification refractory mutation system and Taqman fluorescence quantitative PCR technology enhance detection specificity by inhibiting wild-type template amplification.
  • Safety: Closed-tube detection minimizes contamination risks.
  • Accuracy: Capable of detecting mutant DNA concentrations as low as 1%, surpassing direct sequencing methods.
  • Sensitivity: High sensitivity ensures precise detection.
  • Ease of Operation: User-friendly for clinical settings.

Clinical Significance
Detecting K-ras mutations in benign tumors can indicate potential malignant transformation, guiding effective targeted drug selection (e.g., Erbitux, Panitumumab) for individualized treatment.

Packing Specifications
The kit includes 12 tests per package and is suitable for various tumor tissue samples, including fresh, frozen, or paraffin-embedded tissues.

Contact Information
Jiangsu Mole BioScience Co., Ltd. provides contact details for their offices in Hangzhou and Taizhou, China, for further inquiries.
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Catalog excerpts

T021T012B0C2-1

K-ras Gene Muta�on Detec�on Kit (Fluorescent Probe-Based Real-Time PCR Assay) ——Auxiliary diagnos�c indicators (DNA) for the individualized treatment plan for cancer pa�ents Background Overview The K-ras gene is located on chromosome 12 and plays an important role in the growth of human tumors. The normal K-ras gene can regulate the cell growth path. Once the K-ras gene is mutated and it permanently ac�vated, then intracellular signal conduc�on is disturbed, which leads to con�nuous cell growth and prevents cell apoptosis, thereby causing cancer. K-ras Gene Muta�on Frequency Pancreatic Cancer Lung Cancer Mole Biology reserves the right to modify and interpret the pictures, text and data in this man

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T021T012B0C2-2

Product Advantage Clinical significance Easy High Accuracy Operation Comple�ng the test within 3 hours from submi�ng the specimen to ge�ng the result High Safety Reliable results and reducing false nega�ve test results through internal control gene supervision High Sensitivity Accurate detec�on of mutant DNA with concentra�on as low as 1%, be�er than direct sequencing method Reducing pollu�ons through the closed-tube detec�on Strong Specificity Amplifica�on refractory muta�on system combined with Taqman fluorescence quan�ta�ve PCR technology, inhibi�ng wild-type template amplifica�on and improving...

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Archived catalogs

  1. B052T050B0C2

    2  Pages

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