Clinical Consistency and Reliability Validation of JZ Biotech SDMA Assay KeyWord: SDMA, JZ Biotech, Method Comparison, Clinical Agreement, High Consistency, Low Systematic Bias, Reliability 1. Introduction 4.1 Descriptive Statistics Symmetric Dimethylarginine (SDMA) is a biomarker widely used in veterinary and human medicine to assess renal function. Accurate measurement of SDMA is critical for early detection of kidney disease. JZ Biotech and brand A are two prominent diagnostic companies offering SDMA testing solutions. This report compares SDMA results obtained from both systems to evaluate their agreement and correlation, which is essential for Pearson’s r: 0.93 (p < 0.001), indicating a strong linear relationship (Figure 1). Regression Equation: brand A = 0.85 x JZ Biotech +1.5 clinical decision-making and harmonizing laboratory (R2 = 0.86). To compare the analytical performance of JZ Biotech and brand A SDMA assays by: Assessing the correlation between results. Evaluating bias and agreement using statistical methods. Data from cases collected at the Cooperative Animal Hospital from December 2023 to September 2024. Mean Bias: +1.8 pg/dL (JZ Biotech > brand A). 95% Limits of Agreement: -9.2 pg/dL to +12.8

Key Insight: Higher variability observed in samples or special samples and did not affect the overall with SDMA >60 µg/dL (Figure 2) . Figure 2: Bland-Altman Plot High concordance: strong correlation with industry Pearson's correlation coefficient (r = 0.93): the data Lead Clinical Analyst demonstrated a highly linear correlation (p < 0.001) between JZ Biotech and brand A's SDMA results, which met the criteria for interchangeability both statistically and clinically (Figure 1). Prof. Yang Liheng The regression equation (brand A = 0.85 × JZ Biotech + 1.5): the slope was close to 1 (0.85) and the...