Specification of Plasma Fractionator Evaflux 5A 5A10 Material Inner diameter Wall thickness Hollow fiber Ethylene vinyl alcohol copolymer Polycarbonate resin Membrane surface area Outside hollow fibers Inside hollow fibers Priming volume Outer dimension Filled liquid Sterile water Sterilization method Gamma-ray irradiation Note *Please read instructions carefully when using the product. *EvafluxTM is a trademark of KAWASUMI LABORATORIES, INC. For patients with hyperlipidemia refractory to conventional drug therap

What is Familial Hypercholesterolemia (“FH”) ? When should LDL apheresis commence? “FH” is an autosomal dominantly-inherited disease due to a congenital absence of low-density lipoprotein receptor (LDL-R) , that transports cholesterol-carrying lipoprotein particles into cells. A congenital absence of LDL-R results clinically in elevated concentrations of plasma Functional Homozygotes with LDL >500 mg/dL Functional Heterozygotes with no known cardiovascular disease but LDL ≧ 300 mg/dL Homozygous FH Pattern of Inheritance Inheritance of the abnormal gene from both parents Inheritance of the abnormal...

Double / Cascade Filtration Plasmapheresis Flow Diagram of Cascade Filtration (CF) with Evaflux 5A Double/ Cascade Filtration plasmapheresis is one of the LDL apheresis methods with the [ in combination with Centrifugal Cell Separator ] following principle. Plasma Pump Blood cells High molecular weight substances From patient Low molecular weight substances (Albumin etc.) Membrane Plasma Separator or Centrifugal Cell Separator 2 Whole blood is separated into blood cells and plasma. Plasma Fractionator The plasma fraction containing high molecular weight such as Lipids is discarded. Centrifugal...

Removal rate of risk factors It is reported that DFPP using Evaflux 5A achieved the high removal rate of LDL , Lp(a) and Total cholesterol, LDL, Lp(a), and fibrinogen were removed by 60-80% after each session of fibrinogen, which are considered as the risk factors for arteriosclerosis. DFPP treamtnet. Removal rate (％) Fig 3: Removal Rate of Evaflux 5A S.C.is a parameter indicating the membrane permeability at a certain point. (When 4,000 ml of plasma was processed) Fig 2: Sieving Coefficient of “Evaflux” (When 1,000 ml of plasma was processed) Each patient was treated with DFPP at 2 weeks intervals...