KOELIS BEST PAPERS 1st Edition - 2009-2016

Over the past years KOELIS has been featured in many clinical publications reviewed and accepted by international journals. Within the next document you will find abstracts of the best published results. The consequences of these studies include the potential use of multiparametric MRI exams as first-line diagnostic methods, the implementation of targeted, or at least adapted, biopsies, perhaps as a firstline approach but definitely as a second-line approach, as well as active surveillance protocols based on imaging and mapping. Although the effects are still to be measured, these new practices...

Mapping of transrectal ultrasonographic prostate biopsies: quality control and learning curve assessment by image processing Mozer P1, Baumann M, Chevreau G, Moreau-Gaudry A, Bart S, Renard-Penna R, Comperat E, Conort P, Bitker MO, Chartier-Kastler E, Richard F, Troccaz J. 1Department of Urology, Assistance Publique-Hôpitaux de Paris, Paris, France J US Med. 2009 PURPOSE: OBJECTIVE: Mapping of transrectal ultrasonographic (TRUS) prostate biopsies is of fundamental importance for either diagnostic purposes or the management and treatment of prostate cancer, but the localization of the cores seems...

3-Dimensional Elastic Registration System of Prostate Biopsy Location by Real-Time 3-Dimensional Transrectal Ultrasound Guidance With Magnetic Resonance/Transrectal Ultrasound Image Fusion Ukimura O1, Desai MM, Palmer S, Valencerina S, Gross M, Abreu AL, Aron M, Gill IS 1From the Center for Image-Guided Therapy, University of Southern California Institute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California MATERIALS AND METHODS: We used 3 CIRS-053 prostate phantoms containing 3 hypoechoic lesions to perform ultrasound guided biopsy and 3 CIRS066 phantoms...

MRI and ultrasound-guided prostate biopsy using soft image fusion Rud E1, Baco E, Eggesbø HB. 1Division of Diagnostics and Intervention, Department of Radiology and Nuclear Medicine, Oslo University Hospital Anti cancer. 2012 OBJECTIVES: Transrectal ultrasound (TRUS)-guided random biopsies is the gold standard when diagnosing prostate cancer. A new 3D system with organ tracking, allows accurate targeted biopsies using magnetic resonance imaging (MRI) and TRUS soft image fusion. The aim of the study was to evaluate the accuracy of targeted biopsies. MATERIALS AND METHODS: Retrospective study of...

Prebiopsy Magnetic Resonance Imaging and Prostate Cancer Detection: Comparison of Random and Targeted Biopsies Nicolas Barry Delongchamps,* Michaël Peyromaure, Alexandre Schull, Frédéric Beuvon, Naïm Bouazza, Thierry Flam, Marc Zerbib, Naira Muradyan, Paul Legman and François Cornud From the Departments of Urology (NBD, MP, TF, MZ), Radiology (AS, PL, FC) and Pathology (FB), Assistance Publique-Hôpitaux de Paris, Cochin Hospital and Department of Clinical Research, Assistance Publique-Hôpitaux de Paris, Tarnier Hospital (NB), Paris Descartes University, Sorbonne Paris Cité and Tourville Imaging...

TRUS-MRI image registration: a paradigm shift in the diagnosis of significant prostate cancer Cornud F1, Brolis L, Delongchamps NB, Portalez D, Malavaud B, Renard-Penna R, Mozer P. 1Department of Radiology, Hôpital Cochin, Paris, France COMPARING TECHNOLOGIES ABSTRACT: Accuracy of multiparametric MRI has greatly improved the ability of localizing tumor foci of prostate cancer. This property can be used to perform a TRUS–MR image registration, new technological advance, which allows for an overlay of an MRI onto a TRUS image to target a prostate biopsy toward a suspicious area Three types of registration...

Prospective randomized trial comparing magnetic resonance imaging (MRI)-guided in-bore biopsy to MRI-ultrasound fusion and transrectal ultrasound-guided prostate biopsy in patients with prior negative biopsies Arsov C1, Rabenalt R, Blondin D, Quentin M, Hiester A, Godehardt E, Gabbert HE, Becker N, Antoch G, Albers P, Schimmöller L. 1Department of Urology, Heinrich-Heine University, Düsseldorf, Germany. Eur Urol. 2015 BACKGROUND: A significant proportion of prostate cancers (PCas) are missed by conventional transrectal ultrasound-guided biopsy (TRUS-GB). It remains unclear whether the combined...

Value of multiparametric MRI in the work-up of prostate cancer Cornud F¹, Delongchamps NB, Mozer P, Beuvon F, Schull A, Muradyan N, Peyromaure M. ¹Service de Radiologie, Hôpital Cochin, Paris, France. Curr Urol. 2011 ABSTRACT: The role of magnetic resonance imaging (MRI) in prostate cancer evaluation is controversial and likely underestimated. Technological advances over the past 5 years have demonstrated that multiparametric MRI, including diffusion-weighted imaging (DWI) and dynamic contrast-enhanced MRI, can evaluate the actual tumor burden of a newly diagnosed prostate cancer more accurately...

Targeted MRI-guided prostate biopsies for the detection of prostate cancer: initial clinical experience with real-time 3-dimensional transrectal ultrasound guidance and magnetic resonance/transrectal ultrasound image fusion Fiard G¹, Hohn N, Descotes JL, Rambeaud JJ, Troccaz J, Long JA. ¹Urology Department, Grenoble University Hospital, Grenoble, France. METHODS: We prospectively included 30 patients for suspicion of prostate cancer from November 2011 to August 2012. All patients were previously evaluated by a multiparametric MRI, interpreted by a single radiologist who attributed a Prostate...

Validation of the European Society of Urogenital Radiology scoring system for prostate cancer diagnosis on multiparametric magnetic resonance imaging in a cohort of repeat biopsy patients Portalez D¹, Mozer P, Cornud F, Renard-Penna R, Misrai V, Thoulouzan M, Malavaud B. ¹Department of Radiology, Clinique Pasteur, Toulouse, France. Eur Urol. 2012 BACKGROUND: Wide variations in acquisition protocols and the lack of robust diagnostic criteria make magnetic resonance imaging (MRI) detection of prostate cancer (PCa) one of the most challenging fields in radiology and urology. OBJECTIVE: To validate...