STYL‘One Evo Advanced Compaction Simulator

Research and Development in Focus With over 125 years of combined experience with small-scale, fully instrumented machines, KORSCH and MEDELPHARM have entered into a strategic partnership agreement focused on offering the most advanced line of R&D tablet compression technology in the world. The combined R&D product line meets and exceeds every requirement, from early-stage powder characterization and formulation development, to scale-up and production support. The new R&D line covers the full spectrum of tableting technology from single-layer to five-layer, as well as core coating. MEDELPHARM...

The Most Versatile Compaction Simulator The STYL’One Evo is the most advanced compaction simulator and has the capability to produce virtually any tablet format. The machine features 50 kN compression force capability, which may be applied for both precompression and main compression. The machine permits the use of standard EU/TSM B, D, and EU-441 tooling. Special tooling for larger formats, or multi-tip tools for mini-tablets can also be utilized. The STYL’One Evo is an easy to use, easy to clean R&D press. Work with minimal material quantities Work with standard compression profiles cale-up...

STYL’One Evo is very flexible and can be equipped with a wide range of accessories and software modules to accommodate virtually any product development requirement. The powerful software is very intuitive and the machine permits tablet format changes in just minutes. Compression stud- ies can be planned and executed in a simple and efficient manner, with the capability to create an experiment using standard profiles (saw tooth or square wave), or replicate a high-speed production press. The STYL’One Evo is offered in a medium and high containment execution. Characterization of API and Excipients...

STYL’One Evo Advanced Compaction Simulator Tableting has never been so easy to investigate, from pure API characterization and formulation development to scaleup at production speeds.The versatility of the STYL’One Evo covers all tablet formats from single to five-layer, including core placement for Tab-in-Tab. The machine is equipped with a unique drive technology in a compact footprint which is ideal for the laboratory environment. The simulator can operate in a displacement mode to replicate any rotary press, or in a compression force mode where the system will produce tablets at preset force...

Advanced Instrumentation The STYL’One Evo is designed with the most advanced instrumentation to measure the upper and lower compression force and punch position. Mechanical deformation is measured and compensated by the software. Standard Instrumentation Lower punch force (kN) Mimicking the Dwell Time (flat portion of punch head) Precompression Force Main Compression Force Upper punch force (kN) Ejection Force Upper Punch Displacement Lower punch position (mm) Lower Punch Displacement Optional Instrumentation Material: Lubricated lactose – Main Pressure : 291 MPa (29 kN) – Punches: EU-B, round...

Powerful Software Platform The user-friendly Analis software is installed on a laptop or on a panel PC. Analis controls the STYL’One Evo, collects the data generated, and analyzes the data by plotting a wide range of parameters including manufacturability, tabletabil- ity, compressibility and compactibility. Customized plots for any data parameter are easily developed to explore porosity, ejection stress, elastic recovery. Control System Data Acquisition and Analysis The STYL’One Evo is entirely controlled by software. Each process parameter is precisely entered through a Human Machine Interface...

Efficient Analysis The software has been designed with different modules to accommodate a wide range of tablet formats while keeping ease of use and ergonomics at the heart of the development. Pre-defined compression cycles are readily accessible for more than 200 production tablet presses. In addition, R&D User Friendly Interface The interface looks like a laboratory notebook which simplifies and streamlines experimental design and data analysis. The setup of experiments is done by specifying the tooling type and the compression dynamics (cycles and process parameters). After high frequency...

Analis acquires all data in real time. USP <1062> plots for tablet characterization are integrated into STYL’One Evo software. Manufacturability profiles (tablet breaking force vs compression force) and tabletability profiles (tensile strength vs pressure) are readily available. Compressibility and compactibility profiles can be used when powder true density is known. The user can also build customized plots and reports. As a result, Analis expedites research projects. Single Tablet Capability This part of the software permits analysis of tests conducted on a single tablet. It allows the full...

Unprecedented Flexibility The STYL’One Evo is a flexible research tool that can accommodate virtually any tablet size, shape, and format, making it an ideal choice for OSD development applications. Multi-Layer up to 5 Layers STYL’One Evo can be fitted with one, two or three gravity or forced feeders to produce tablets up to five layers. The multi-layer software module permits the layer parameters to be established based on the tablet format. Critical process parameters including tamping force and filling height of each individual layer as well as precompression, main compression and ejection...

Containment Solutions The STYL’One Evo is designed to work under negative pressure and as such, the standard execution does offer a clean working environment. For applications that require a higher level of powder containment, the system is offered in a medium and high containment execution. The medium containment execution with the Enhanced Operator Safety Enhanced Operator Safety (EOS) EOS adds extra safety by reducing operator exposure to airborne particles during operation. Vacuum and manual control of air flow ensure permanent negative pressure in the compaction area of the simulator. Compaction...