Catalog excerpts

L-Hydro - 2

Sxe the ate 1960S 2 'V-nbc* st Ticthods have been developed of proposed and used lor p'eservafon ol tissue products- These include soiutons containing alcohol high ionc strength of high osmolarity. Most of these methods aim at p'evenlirg the protein components in tissues from s^oslances osed may inhibit subsequent chemical treatment methods or cause complications in SLOsequent processes.

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L-Hydro - 3

Glutaradchyde as tissue preservation has Lee- usee lo' over 40 years, and ■ beer sixcesstul in treat ng different botogCa xenograft tissues used in heart vaVes Glutaradehyde's main (unction is lo establish crossJirk connectons in the collagen [hat can provide structure and Collagen Strand Reactive Groups

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L-Hydro - 4

1 ■ Glutaraldehyde reouces imrnunogenicity: ii is one the main reasons for the success ot this method ol peservatoa such as n giutaradehyde-treateo xenograft r SSJCS tor bbp'osthetic heal valves.3 2- An exce ent slerila^l: One musl remember this when working with a non-g Paraldehyde method 0" treating implanted tissues. 3- Reativety duraole: The durability oJ g jtaraldenyde treated issue valves demonstrated by in vitro fatigue tester, was party resoonsibte lor the successful development o( the clinical glularaldefiyde treated porcine 1 - Cytotoxic: li has been demonstrated that...

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L-Hydro - 5

Many publications have shewn thai gk/tarakJehyde is sM a good option tor tissue treatment, as $ obtains good results for old patients in duratMy and resistance. problem for this technology, for many years methods to reduce calcification have been developed. None of them 100% calcium free, proof that this feature is not well seen in congenital defects repair

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L-Hydro - 6

So What is the Goal in Tissue Treatment? • Establish biological tissue • Inhibit antigenicity • Reduce I Suppress the inflammatory response • Guarantee sterility • Enable cell reconstruction after implant

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L-Hydro - 7

L-Hydro Principles 1. Present (o receptor cells a non viable xenograft matrix (acelular), similar to natural human matrix. 2. Cells grow in same natural function 3. Reconstruction stimulated by similar natural matrix and physiologic conditions In Vivo - tissue engineering." Based or these principles. Labcor in collaboration with Dr. David Cheung, PhD, Heart Institute of Montana5 have developed this method of tissue treatment technology, by the name L-Hydro. Preserve xenog-aft products to be implanted in hLmans as potentially capaole to functonaly reconstruct with no rejection and/or...

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L-Hydro - 8

L-Hydro Tissue Treatment Howitworks Sails ETOH Mild Chemical Oxidation Fresh tssue ts harves:ed TOTH the submerged n a cc*d etharal salts soluticn - Bto Ixrden redxtioa Ptrform mid chemical oxoaxn rraix;rxj pate'itml cxid/aoJe mate^ls that can attract ritiarnmaEcry 'oacticn f'OTi :fic fios: Awcii-kiown psty-giyco w^ch bras tig'iiy to colagen is also added to mask the potential nor- cxractcd anbgoa

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L-Hydro - 9

Anti-Inflammatory Agent Anani-nflammaioiyagcni sacteoo to 'edu<^ ir'LTTTTiuHlofy rt-;-ip::rse Dung \no rplant procedure a hecann ccatng rodjeos eel Mild Chemical exact properties ol tfee

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L-Hydro - 10

Inflammatory Cells Endothelial Cells 'issue Colls

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L-Hydro - 11

Tissue Matrix inflammatory cells, endothelial cells are permitted to grow. This way endothelial cells allows infiltration of connective cells becoming the synthesis

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L-Hydro - 12

• PolymcnTation roacton • Coating. Cytotoxic ghJtaalOef-iyoe • Vfcxtficalon of MUno Groups • Break down of toxc poyne«s ■ °e&$ton\ resduaJ arcgeneoTy • ^erasta"! esdual cytotoxicity Conventional - depends on Toxicity of giutaiakJohyo© mprovod TILJIII stop reduction of boburdon, Inon Iral sto- zatior 1 Aia&yde slorage/shipping solulion * Coating, nor Cytotoxic poty gfycoi • No froaftcalior. o* ATWIO Grcxx)S • No txeak down of towc poymers • No persistent re$<|jaJ artgeneoly • No parstslent resdual cytotoxicity • Mull* step reduction of C*oburden - L-Hyc»o process • Final liquid prttse...

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L-Hydro - 13

Endothefial Cells

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L-Hydro - 14

• Tissue Growth - New Tissue Matrix • No persistent residuai antigenicity • Very iow level of calcification • Preserve natural structural and mechanical characteristics Poicine pulmora-y vave

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L-Hydro - 15

Biological tissue treatments • Heart valves Labcor Products Treated with L-Hydro • Babygraft / Corograft / Perigraft (Mesenteric artery) (Pericardium conduit, portion ctosecf with porcine pulmonary valve) Qfobed jugular vein) (Pericardium repair membrane)

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L-Hydro - 17

1 - Wtlans, Meivyn A>, ER.C.S.: Tissue Vaves in Young Patients - A recipe tor Disaster. Department Of Cardio thorasic sygery. Provincial HosoitaL Pen E zabeth, South Africa Journal ol Carcfcac Surgeiy Vol 6, No 4, 2 - Jameson, W. R trie e: a). : Carpen:ier tdwards Sandard Porcioe Biophfosthe&s: A 21 -years Experience, University of British Cclurrkba. Vancojvor, Canada- Ann 3 - Salgaler M, L, Bajpai R K.; Immunogenicity ol glu:araklchyOo-l'C3tcd bovho ooricaraal tissue xonograf:s in rabbrls. Unheralty ol Dayton, Daylon. Ohio. Journal of Biomedical Materials Research, 1985; 19:1-12 4 - Nina...

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