France Technopôle de l’Aube BP 2 10902 Troyes Cedex 9 France +33 (0)3 25 82 32 63 www.ldrmedical.com China Unit 08, Level 16, Building A, Beijing Global Trade Center #36 North Third Ring Road East, Dongcheng District, Beijing, China, 100013 +86 10 58256655 Brazil Rua Bela Vista, 77 - Centro São Bernardo do Campo CEP: 09715-030 São Paulo Brazil +55 11 43327755 United States 4030 West Braker Lane, Suite 360 Austin, Texas 78759 512.344.3333 LUMBAR ARTIFICIAL DISC ( MOBILE BEARING ARTIFICIAL DISC TECHNOLOGY CERVICAL ARTIFICIAL DISC LDR, LDR Spine, LDR Médical, BF+, BF+(ph), Easyspine, Laminotome, MC+, Mobi, Mobi-C, Mobi-L, Mobidisc, ROI, ROI-A, ROI-C, ROI-MC+, ROI-T and verteBRIDGE are trademarks or registered trademarks of LDR Holding Corporation or its affiliates in France, the United States or other countries.

MOBILE BEARING ARTIFICIAL DISC TECHNOLOGY The controlled mobility of the mobile insert is the foundation of the Mobi artificial disc technology. This platform of second generation artificial discs was designed by a team of surgeons specializing in spinal arthroplasty. CONTROLLED MOBILITY Encourages respect of the instantaneous axes of rotation for a return to physiological mobility of the intervertebral disc. Reduces the stresses on the posterior facet joints. Mobidisc was first implanted in November 2003. Since then, over 2000 arthroplasties were completed worldwide prior to 2008. Follow-up...

Demand Safety • Technique is very similar to standard and reproducible ALIF procedure, while the mobile bearing technology and complete discectomy restores mobility. Chamfers on the edges of the superior and inferior endplates help to ease insertion and help to ensure proper endplate conformity. • No over distraction. • Implantation “Guide” secures surgical approach by protecting the large blood vessels while maintaining the height during insertion. • One-step implantation. • Minimal invasion of vertebral endplates. • Self-guided prosthesis. The reduction of stresses on the bone to implant interface...

Restore Mobility • Insert mobility provides six degrees of freedom and is self-controlled by the compression of the implant during flexion/extension and side bending. • Two lateral stops on the inferior plate help to control mobility of the insert while preventing expulsion. • Optimal patient anatomy matching with nine implant foot print sizes available. • Five insert height options represent an overall implant height range of 9.5mm to 14mm. • Each plate is offered in three lordotic options 0°, 5° and 10°. MOBILE BEARING ARTIFICIAL DISC TECHNOLOGY

Provide Control • The mobile insert is free to translate and rotate on the inferior plate between the four peripheral stops which control mobility and prevent expulsion. • The contact surface is optimized and perfectly balanced between the flat and spherical surfaces. • The contact area is optimized to provide improved lubrication for the articulation; optimizing the wear characteristics between the Cobalt Chrome and Polyethylene. • Modular keels are placed on implant endplates prior to disc assembly for implant to bone fixation. • The pure Titanium outer surface with hydroxyapatite coating encourages...

Provide Control Secure yet conservative implant to bone fixation • The contact area is optimized to provide improved lubrication of the articulation and is perfectly balanced between the flat and spherical surfaces. • Four overall footprint sizes and insert height options for a total implant height of of 4.5, 5, 6 and 7mm allow for optimal anatomic congruency. • Captured insert design resists expulsion. • Design preserves the Instantaneous Axis of Rotation (IAR) allowing more natural physiological movement of the treated segment. • Thin Cobalt Chrome endplates feature a roughened titanium surface...

Restore Mobility • Cobalt chrome and polyethylene articulation provide optimal wear characteristics; while the insert mobility supports six degrees of freedom for the device. • Mobility is self-controlled by the physiological forces applied to the insert during Flexion/Extension and Side Bending. • Four peripheral stops control the mobility of the insert in all axes. Demand Safety • All Mobi-C implants are delivered in sterile packages, under blister pack, with sterilization control stickers guaranteeing the safety of each implant. • LDR packaging ensures absolute traceability from the first...

Expect Results Natural Design = Natural Motion First implanted in November 2004, over 5000 Mobi-C arthroplasties were completed worldwide in the first three years of use. Follow-up of 275 patients with average follow-up of 17 months indicate exceptional results with 91.2% of patients being “Satisfied” or “Very Satisfied” with the surgery. 96.6% of the patients reported that they would undergo the surgery again. Natural movement is the result of our conservative implantation technique, superior device size range and our unique, specific to cervical, engineering specifications. All these features...

Expect Results Natural Design = Natural Motion First implanted in November 2004, over 5000 Mobi-C arthroplasties were completed worldwide in the first three years of use. Follow-up of 275 patients with average follow-up of 17 months indicate exceptional results with 91.2% of patients being “Satisfied” or “Very Satisfied” with the surgery. 96.6% of the patients reported that they would undergo the surgery again. Natural movement is the result of our conservative implantation technique, superior device size range and our unique, specific to cervical, engineering specifications. All these features...

Restore Mobility • Cobalt chrome and polyethylene articulation provide optimal wear characteristics; while the insert mobility supports six degrees of freedom for the device. • Mobility is self-controlled by the physiological forces applied to the insert during Flexion/Extension and Side Bending. • Four peripheral stops control the mobility of the insert in all axes. Demand Safety • All Mobi-C implants are delivered in sterile packages, under blister pack, with sterilization control stickers guaranteeing the safety of each implant. • LDR packaging ensures absolute traceability from the first...