LOTHAR MEDICAL Ambulatory Lung Diagnostic System ALDS Professional Ambulatory Lung Diagnostic System Professional The Ambulatory Lung Diagnostic System Professional (ALDS PRO) is a single-device instrument for measuring Airway Oscillometry, Forced Spirometry and Exhaled Nitric Oxide (FeNO). The system's cloud-based algorithm evaluates the readings and uses the resulting clinical outcome parameters along with patient history data to provide physicians with a physiological interpretation of the results. The algorithm is based on published concepts for interpreting obstructive and restrictive patterns that indicate corresponding limitations. The ALDS is specifically designed for general practitioners. The system fulfills modern requirements for mobility and robustness to efficiently examine many patients per day. The typical duration of an examination is only a few minutes per patient and implements a guided clinical pathway including airway resistances, forced expiratory flows and the fractional concentration of exhaled NO. The opportunity to combine these tests provides a comprehensive and multidimensional evaluation of the lung function. Airway Oscillometry Airway Oscillometry is a simple, non-invasive technique that measures the mechanical impedance of the lungs - a combination of respiratory resistance (airway openness) and reactance (elasticity and inertance of the airways). During the test, the patient breathes normally and calmly through the ALDS device. While doing so, the system delivers gentle pressure oscillation to the lung. These sound waves travel through the airways, and the device captures the resulting pressure and airflow at the mouth. The system then calculates clinically relevant, frequencydependent impedance parameters, providing valuable insights into lung mechanics without requiring forced breathing maneuvers. Advanced Pulmonary Function Assessment FeNO Fractional Exhaled Nitric Oxide Forced Spirometry Exhaled Nitric Oxide (FeNO) Forced Spirometry is a diagnostic technique used to measure airflow during a forced breathing maneuver. During this test, the patient performs a spirometry maneuver - taking a deep breath and then exhaling forcefully through the ALDS device. The system captures the airflow and calculates clinically relevant flow and volume parameters, offering valuable insights into the patient’s pulmonary function. Exhaled nitric oxide (NO) is measured when asthma or other respiratory conditions involving airway inflammation are suspected. Nitric oxide (NO) is a gas produced by certain cells during an inflammatory response. The fraction of exhaled NO (FeNO) serves as a biomarker for diagnosing, monitoring, and guiding treatment in both adults and children with asthma. FeNO is particularly useful in diagnosing asthma and determining which patients are likely to benefit from inhaled corticosteroids. Additionally, FeNO helps predict exacerbations and assess the potential for successful reduction or discontinuation of corticosteroid therapy. LOTHAR MEDICAL GmbH Magdalene-Schoch-Str. 5 97074 Wuerzburg, Germany ALDS PRO-Product-Flyer - Version 2.0

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