Ambulatory Lung Diagnostic System LOTHAR MEDICAL Ambulatory Lung Diagnostic System The Ambulatory Lung Diagnostic System (ALDS) is a two-in-one device designed to perform both Airway Oscillometry and Forced Spirometry. This innovative system leverages a cloud-based algorithm to analyze test results, integrating clinical outcome parameters with patient history to deliver a clear physiological interpretation of lung function for healthcare providers. The system algorithm identifies obstructive and restrictive patterns, helping clinicians detect and understand corresponding respiratory limitations. Engineered for mobility, durability, and efficiency, the ALDS supports high patient throughput with each test typically taking just a few minutes. By combining both diagnostic methods in daily diagnostic routines, the ALDS offers a comprehensive, multidimensional assessment of lung function, enhancing pulmonary diagnostics. Airway Oscillometry Ambulatory Lung Diagnostic Airway Oscillometry is a simple, non-invasive technique that measures the mechanical impedance of the lungs - a combination of respiratory resistance (airway openness) and reactance (elasticity and inertance of the airways). During the test, the patient breathes normally and calmly through the ALDS device. While doing so, the system delivers gentle pressure oscillation to the lung. These sound waves travel through the airways, and the device captures the resulting pressure and airflow at the mouth. The system then calculates clinically relevant, frequencydependent impedance parameters, providing valuable insights into lung mechanics without requiring forced breathing maneuvers. Forced Spirometry Forced Spirometry is a diagnostic technique used to measure airflow during a forced breathing maneuver. During this test, the patient performs a spirometry maneuver - taking a deep breath and then exhaling forcefully through the ALDS device. The system captures the airflow and calculates clinically relevant flow and volume parameters, offering valuable insights into the patient’s pulmonary function. LOTHAR MEDICAL GmbH Magdalene-Schoch-Str. 5 97074 Wuerzburg, Germany Advanced Spirometry for Comprehensive Lung Health Monitoring

LOTHAR MEDICAL Normal at rest You should measure post spirometry if COPD is suspected Oscillometry determine response to bronchodilator measure airway resistance Clinical Pathway Complex Limitation You should consider referral of the patient You should consider treatment for You should consider treatment for Normal at rest You should conduct a provocation test if Asthma is suspected Note: If indicated you should consider referral of the patient. Device Specification Technical Parameters Technical Standards Clinical Parameters LOTHAR MEDICAL GmbH Magdalene-Schoch-Str. 5 97074 Wuerzburg, Germany...