Enhancing Pulmonary Diagnostics with the Ambulatory Lung Diagnostic System ALDS LOTHAR MEDICAL Ambulatory Lung Diagnostic System The Ambulatory Lung Diagnostic System (ALDS) is a two-in-one device designed to perform both Airway Oscillometry and Forced Spirometry. This innovative system leverages a cloud-based algorithm to analyze test results, integrating clinical outcome parameters with patient history to deliver a clear physiological interpretation of lung function for healthcare providers. The system algorithm identifies obstructive and restrictive patterns, helping clinicians detect and understand corresponding respiratory limitations. Engineered for mobility, durability, and efficiency, the ALDS supports high patient throughput with each test typically taking just a few minutes. By combining both diagnostic methods in daily diagnostic routines, the ALDS offers a comprehensive, multidimensional assessment of lung function, enhancing pulmonary diagnostics. Airway Oscillometry Ambulatory Lung Diagnostic Airway Oscillometry is a simple, non-invasive technique that measures the mechanical impedance of the lungs - a combination of respiratory resistance (airway openness) and reactance (elasticity and inertance of the airways). During the test, the patient breathes normally and calmly through the ALDS device. While doing so, the system delivers gentle pressure oscillation to the lung. These sound waves travel through the airways, and the device captures the resulting pressure and airflow at the mouth. The system then calculates clinically relevant, frequencydependent impedance parameters, providing valuable insights into lung mechanics without requiring forced breathing maneuvers. Forced Spirometry Forced Spirometry is a diagnostic technique used to measure airflow during a forced breathing maneuver. During this test, the patient performs a spirometry maneuver - taking a deep breath and then exhaling forcefully through the ALDS device. The system captures the airflow and calculates clinically relevant flow and volume parameters, offering valuable insights into the patient’s pulmonary function. SPIRO Advanced Spirometry for Comprehensive Lung Health Monitoring LOTHAR MEDICAL GmbH Magdalene-Schoch-Str. 5 97074 Wuerzburg, Germany

Oscillometry Spirometry remains the most widely used and validated method for assessing pulmonary function. The ALDS measures key parameters such as: © Forced Vital Capacity (FVC) © Forced Expiratory Volume in 1 second (FEV1) These values are key for diagnosing lung diseases, assessing severity, and tracking treatment. Spirometry is recommended by major guidelines such as GINA and GOLD. However, spirometry has notable limitations that underscore the need for complementary tools that can provide additional insights into lung function, particularly in challenging patient populations: • Effort-dependence:...

• History: 25-pack-year smoking history, occasional cough, mild exertional dyspnea • No prior diagnosis of asthma or COPD ClinicalPresentation The patient presented for a routine health checkup. He reported mild shortness of breath during physical activity but denied wheezing or frequent respiratory infections. Given his smoking history, the clinician opted for a comprehensive lung function assessment. SpirometryResults (5) Recommended next examination step: You should consider testing for reversibility by administering a bronchodilator followed by an oscillometry • R5 (total airway resistance):...

measure airway resistance determine response to bronchodilator Complex Limitation You should consider referral of the patient Normal at rest You should measure post spirometry if COPD is suspected You should consider treatment for You should consider treatment for Normal at rest You should conduct a provocation test if Asthma is suspected Note: If indicated you should consider referral of the patient. Technical Standards Technical Parameters Airway Oscillometry Forced Spirometry Forced expiratory volumes LOTHAR MEDICAL GmbH Magdalene-Schoch-Str. 5 97074 Wuerzburg, Germany + 49 931 6193816-0 sales@...