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WAVEsystem Next-generation bioanalytical instruments for drug discovery

The wave of the future in kinetics Kinetics in hours instead of days Modern label-free technology meets no-clog microfluidics and automated software to provide superior affinity and kinetic data quality and challenging sample compatibility.

Real samples, real data.

The Creoptix WAVEsystem puts a breakthrough level of kinetics analysis at your fingertips by pushing the boundaries of affinity range and sample compatibility. The system’s exceptionally high data quality, sample compatibility and automated software facilitates drug discovery and enable new inroads into R&D. Intuitive wizards Move seamlessly from sample to data in a simple stepwise process. Automated software enables outputs to be generated at the touch of a button. Wizards guide the user through experimental set up, kinetic evaluation and report generation, with open access formats...

Measure biological interactions in relevant contexts fast Confidently detect and quantify biological interactions in real-time, for high-quality kinetic data across a broader range of samples than traditional equipment. With waveRAPID®, Creoptix introduced a new way of measuring kinetics to boost throughput. Instead of relying on a titration series in conventional kinetics, waveRAPID injects a single concentration, pulsing the sample over the sensing surface at increasing durations. From a single well, kinetics can be derived: the on-rate, off-rate, affinity and Rmax. No-clog microfluidics...

label-free data like you’ve never seen before

Confidence in kinetic measurements Real is measuring kinetics of biological interactions in relevant contexts. Only the WAVE innovative microfluidic cartridge tolerates native, physiological and harsh conditions, providing access to new data not possible before. real is crude small molecule development Capture fast off-rates of weakly binding fragments and high-quality low potency leads for more suc-cessful drug discovery. • Separate binders from non-binders with offrate kinetic analysis of crude reac-tion mixtures • Resolve weak binders with off-rates as fast as 10 s–1. • Measure in...

real is (less) diluted Serology - serum, plasma and more Measure antibody kinetics in (un)diluted serum and plasma while reducing cross-contamination and potential clogging. Accurately measure binding kinetics in conditions closer to real life and confidently characterize the tightest binders in: • 100% blood serum or plasma • Cell extracts 90% Serum • Cell culture supernatant Biologics development Measure more than just affinity, even in the low pM range, while confirming and entichign ELISA data. • Slow off-rate analysis of high-affinity binders • Detection of anti-drug antibodies (ADA)...

Creoptix WAVE GENERAL Noise (RMS) Readout Frequency Association Const. Range ka = 102 – 5x107 M-1 sec–1 (small molecules) ka = 102 – 3x109 M-1 sec–1 (large molecules) Dissociation Const. Range Analysis temperature range Molecular Weight Limit waveRAPID Functionality FLUIDICS Flow Channels / Path Channel Referencing Flow Cells Sealed, disposable, integrated into disposable WAVEchip Flow Rate Crude Sample Robustness SAMPLE HANDLING 2x microtiter plates (96 or 384 well, standard or deep well) or vial racks (48 positions of 1.5ml) Sample Volume Required µ Models & Specifications Sample Capacity...

Creoptix WAVEdelta GENERAL Noise (RMS) Readout Frequency Association Const. Range ka = 102 – 5x107 M-1 sec–1 (small molecules) ka = 102 – 3x109 M-1 sec–1 (large molecules) Dissociation Const. Range Analysis temperature range Molecular Weight Limit waveRAPID Functionality FLUIDICS Flow Channels / Path Channel Referencing Flow Cells Sealed, disposable, integrated into disposable WAVEchip Flow Rate Crude Sample Robustness SAMPLE HANDLING Sample Capacity 2x microtiter plates (96 or 384 well, standard or deep well) or vial racks (48 positions of 1.5ml) Automatic switching between 4 buffers...

kinetics in hours instead of days To stay up-to-date with our latest developments, visit www.creoptix.com To make the most out of your WAVEsystem, contact our team at support.creoptix@malvernpanalytical.com To make the most out of your WAVEsystem, contact our team at support.creoptix@malvernpanalytical.com label-free data like you've never seen before Creoptix AG | Zugerstrasse 76 | 8820 Wädenswil | Switzerland (HQ) www.creoptix.com | +41 44 533 26 60 ©2022 Creoptix Sensors/Creoptix, WAVEchip, WAVEcore and waveRAPID are trademarks of Creoptix AG, All goods and support services sold by...