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Malvern Panalytical
Inline Particle Measurement

Inline Particle Measurement

Product catalog summary

Introduction
Inline particle measurement is crucial in the chemical, pharmaceutical, and food industries, where materials are often processed as dry powders or granules. Real-time data from in-line particle size measurement enhances process control, reduces waste, and improves product consistency.

Benefits of In-line Particle Measurement

Improves process understanding and efficiency.
Reduces processing times and waste.
Enables quick detection and correction of process deviations.
Enhances safety and minimizes risks.
Increases process utilization while maintaining product quality.
Improves product reproducibility and consistency.
Accelerates process scale-up and reduces time to market.

Measurement Principle
The Parsum probe uses a patented spatial filter technique to measure particle size distributions. It detects particles passing through a laser beam, calculating their velocity and size. The system provides real-time particle size trends, allowing for process performance insights.

Types of Probes

IPP 80-P: Designed for pharmaceutical and food processes, suitable for batch and continuous production, ATEX certified for Zone 0/20.
IPP 70-S: Suitable for dense particle flows, monitors performance, and reports status via LEDs and process control systems.
IPP 70-Se: Intrinsically safe for explosive atmospheres, ATEX certified for Zone 0 and Zone 20.
IPP 70-SL/SLe: Customizable length for large process spaces, ATEX certified versions available.

Process Interface and Accessories
Accessories include air purge units and sample dispersers, ensuring robust measurements and realistic particle size distribution assessments.

Software

IPP: Core measurement interface for control and result presentation.
Analog Output: Transmits results to control systems.
ParsumView: Ensures compliance with FDA’s 21CFR Part 11, offers enhanced GUI and data processing.
OPC-Server: Facilitates data transfer and remote control for multiple probes.
LabView-VIs: Allows development of interfaces to access probe data.
LogAnalyzer and ExcelConnect: Enable data analysis and real-time plotting in Excel.

Applications

Determining layer thickness in pharmaceutical processes.
Detecting screen breakage in milling processes.
Tracking granulation endpoints in mixing processes.
Monitoring fluidized bed granulation for consistency.
Continuous measurement in washing powder granulation.
Monitoring grain size during grinding processes.
Controlling material feed in fluid bed dryers.
Detecting material segregation during silo discharge.

Technical Data

Measurement Range: 50 μm to 6000 μm, velocity 0.01 m/s to 50 m/s.
Maximum Concentration: Up to 30% (vol.), depending on particle properties.
Temperature Range: Up to +100°C at measurement volume, +60°C at electronics enclosure.
Contact Materials: Stainless steel 316 L, sapphire windows.
Maximum Cable Length: 100 m, extendable with cable amplifier.

Contact Information
For Germany, Austria, and Switzerland, contact Parsum GmbH. For other countries, contact Malvern Instruments Worldwide.

Catalog excerpts

Valuable Insight in your Process

Open the catalog to page 1

= Our offer Just under three quarters of all materials processed in the chemical, pharmaceutical and food industries are present as dry powders or granules. As a result, in many processing steps the particle size and size distribution is one of the most important material characteristics. Whereas conventional laboratory analysis is designed to determine the particle size in order to obtain information regarding the quality of end products and intermediates, in-line particle size measurement provides the direct, real time data on the performance of a manufacturing process that is often decisive...

Open the catalog to page 2

This probe has been designed to measure the particle size and size distribution of powders, pellets or granules in pharmaceutical and food processes. It is a valuable PAT tool that can be easily installed in areas where cleanliness, cleanability and hygiene are important requirements. The probe can be used for conventional batch processes or for monitoring continuous production processes and includes enhanced self-diagnostic features. It is ATEX certified for Zone 0/20 operation. This universal in-line particle sizing probe is designed for direct use in dense particle flows such as those found...

Open the catalog to page 3

= Examples of application =■'Technical Data: Continually determine the layer thickness and the agglomerate fraction in pharmaceutical fluidized bed pellet coating processes. Measurement Range: particle size: 50 ^im ... 6000 ^im velocity: 0,01 m/s ... 50 m/s Detect screen breakage in milling processes for the production of cellulose fibers by identifying the presence of single large particles. Maximum Concentration: depends from particle properties, up to 30 % (vol.) Track progress and determine the granulation end point in high-shear mixing processes, in order to enable faster process scale-up....

Open the catalog to page 4

All Malvern Panalytical catalogs and technical brochures

*Prices are pre-tax. They exclude delivery charges and customs duties and do not include additional charges for installation or activation options. Prices are indicative only and may vary by country, with changes to the cost of raw materials and exchange rates.

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