Freeze Drying Systems for Pharmaceutical Production Customised Solutions Designed & Made in Germany

Martin Christ is a world leader in the development and manufacturing of freeze dryers, with over 65 years of experience. We would now like to invite you in the following pages to learn a little more about at the developments outlined above. We want to present to you now the centrepiece of our company – the area in which all our expertise and experience come together: We are talking about the construction of customised systems for sterile production of pharmaceutical products. In this sector too, the name Martin Christ stands for utmost customer satisfaction all over the world. We develop and...

Optimised system design for aseptic production of active substances For GMP processes in the fields of pharmaceutical, diagnostic and specialist applications we offer the double-chamber principle, developed by us, with a large opening to the ice condenser positioned below the drying chamber. The large cross-section creates ideal flow conditions for water vapour. Especially at the start of the drying process, undesirably large pressure differences between the drying chamber and the ice condenser chamber can occur if the opening is not large enough to handle the enormous quantities of water vapour...

Advantages of the Martin Christ Epsilon DS freeze dryers: • Customised, and space-saving due to compact frame design • Process specific system configurations such as door designs with door-in-door variants, or slot door and separate inspection door • Automation with Siemens S7 and user-friendly process visualisation LPCplus • Safe operation than ks to redundant systems • Effective and validated CIP cleaning • Integrated, fully automatic filter test (FIT) • Pressure chamber > 2.5 bar for steam sterilisation (SIP) from 121 °C up to 135 °C • Hydraulic-pneumatic door locking system • Thoroughly tested...

6 Routine applications | LDplus Display

Customised System Layout The main criterion in selecting a freeze drying system is the desired quality of the final product. Combined with other requirements, for example with regard to incorporation into process sequences, space requirements, high cost effectiveness, and compliance with all relevant legal requirements. Based on our tried and tested double-chamber principle, we plan and implement your requirements: product-oriented, process-optimised and adapted for each individual application. Your process decides The integration of the system technology into the process flow must be guaranteed....

Detail Engineering at the Highest Level Tailored and energy-saving refrigiration systems Cooling systems of production freeze driers normally use standard commercially available piston compressors, which are equipped with up to six independent cooling systems depending on the size of the system. As an alternative when power requirements are high, screw compressors can be installed. During the freezing process the entire cooling system works primarily for shelf temperature control, and during the drying process – depending on the process section – mainly on the ice condenser. The intelligent energy...

Best quality shelf design The shelves for the pharmaceutical product are made from highquality stainless steel. They are welded together with the latest laser methods and achieve a surface finish of Ra ≤ 0.6 µm. The eveness is ± 0.5 mm over the entire shelf. The FEM-optimised design used results in a robust and yet weightsaving layout. Heating and cooling times are reduced. The temperature distribution on the shelf and over the entire set of shelves is ± 1 Kelvin. This temperature distribution is being demonstrated by shelf mapping as part of the acceptance process at our factory. The number...

Cleaning of the freeze dryer is normally carried out automatically with Cleaning in Place methods – or CIP for short. In this method the entire drying chamber including the shelves, hydraulic cylinder bellows and the ice condenser chamber with the ice condenser coils can be reached by the integral conical nozzle system. This fully automatic cleaning process is validated and complies with the ISO 13408 guidelines. In recent years the circulation method with its reduced volume flow has become more and more industrial standard. Process sequence (example): 1 Cleaning step in the continuous method...

The CIP process is normally followed by steam sterilization, or SIP (Sterilization in Place). Again, this process is validated and runs fully automatically. Steam sterilization and cleaning process use the same set of piping. By exact determination of the cold spot in the overall system (on the ice condenser drain) and monitoring of the temperature at this point, the sterilization process is controlled in an adjustable manner using the LPCplus process visualisation software (pressure or temperature, duration). The filter integrity test (FIT) is usually used to test the proper operation (“integrity”)...

Application Optimised Automation Concept The Martin Christ automation concept combines the standards of leading process automation solutions with the focus on the freeze drying processes of the pharmaceutical industry. This results in a corresponding system for both the process viualization and the process data management. • Siemens S7-400 control system • Process visualization with the Martin Christ LPCplus process control system • Integration and interfacing of loading and unloading with other external systems • Operation of several stations, e.g. in the clean room and the control room • Intrinsically...

Process Visualization Specific to Freeze Drying Production freeze dryers in the pharmaceutical industry should offer more than just comprehensive monitoring of running processes – e.g. functions for quality assurance. Martin Christ units feature fully automatic process control with direct parameter adjustment to give you optimal protection against spoiled batches of your valuable products. Process visualization with LPCplus Our user-friendly software for process and system control provides a uniform user interface for all freeze dryer functions and associated administration tasks. The SCADA software...