Pilot Freeze Dryers Smart Processes Powerful and highly efficient

Best equipment for R&D and small production Pilot freeze dryers from Martin Christ are ideal for R&D or small production systems for new products. All three models are suitable for the freeze drying of solids or liquids in a wide variation of containers, including ampoules, vials, glass flasks, plasma bottles, dishes, etc. The units share a geometrical likeness as production-scale units and use similar temperature control principles. Epsilon 1-4 LSCplus Epsilon 2-4 LSCplus 4 kg The Epsilon 1-4 LSCplus and Epsilon 2-4 LSCplus benchtop freeze dryers are singlechamber units with a 4 kg ice condenser...

Design features General features • Minimised space requirements: very compact design with high efficiency and economical operation. • Powerful shelf temperature control Actively cooled and heated shelves 6 and 10 kg units: control range –50 °C or –60 °C to +60 °C, shelf temperature accuracy ±1 K, cool down/heat up benchtop freeze dryers > 1 K (+20 °C to –40 °C) 4 kg units: control range -45 °C (Epsilon 1-4 LSCplus) or –75°C (Epsilon 2-4 LSCplus) to +60 °C, shelf temperature accuracy better than ±2 K – (temperature distribution can be improved by utilising aluminium thermoblocks), cool down/heat...

Widest range of custom solutions The Epsilon Pilot range from Martin Christ sets the standard for high quality and productive pilot systems. These freeze dryers look and operate nearly the same as large production freeze dryers. They provide the highest level of functions for successful research and process development. Pilot systems with custom configurations have been supplied to global pharmaceutical companies and biotech start-ups. Modifications include: • Cleanroom integration • Isolator/glove box integration • Process optimisation tools Process Analytical Technology (PAT) -- LyoControl...

Advanced system technology Martin Christ freeze dryers are high performance universal units for the freeze drying of solid or liquid products in a wide variety of vials, trays or other containers. Typical applications for freeze drying are materials such as bacterial and virus cultures, blood plasma, serum fractions, antibodies, sera, vaccines, biopharmaceutical complex proteins, plant extracts and diagnostic test kits. All operations are possible inside our single and double chamber systems: • Pre-freezing of products on liquid-controlled shelves down to a shelf temperature of –75 °C (depending...

Double-chamber systems • Ice condenser directly behind the drying chamber • Large cross-section between drying and ice condenser chambers • Nearly no pressure drop between both chambers. Excellent drying rates for sensitive materials and products with low eutectic points or low collapse temperatures • Powerful shelf temperature control Liquid cooled and heated shelves, control range –50 °C to +60 °C (Epsilon 2-6D LSCplus) or –60 °C to +60 °C (Epsilon 2-10D LSCplus), cooling/heating rate up to >1 K/min (+20 °C to –40 °C), shelf temperature accuracy better than ±1 K • Intermediate valve for determination...

LSCplus controller To aid in designing your process sequences, we have integrated our highly regarded LSCplus controller with its production-oriented user interface into every model. All of the accessories are also integrated. Automatic process sequences ensure reproducible results. • Symbol driven colour touchscreen control • Automatic or manual freeze drying sequence • Intuitive input of programs based on different pre-installed freeze drying sequences or recipes • Graphical diagram of the freeze drying process • Automatic program adaptation according to actual product conditions • Memory for...

Process monitoring and documentation We realise that process monitoring and documentation are crucial for the validation of many applications regardless of recipe and batch size. Documentation and archiving of all process data is possible with the LyoLogplus software, which can be installed on a separate PC. The data can be transferred from the freeze drying system to the PC on a USB stick or directly over Ethernet. LyoLogplus enables seamless documentation and post-process analysis with an intuitive user interface. LPCplus can also be used. With LPCplus you can develop programs for freeze drying...

Process optimisation – in detail The LSCplus series offers a variety of options to optimise your freeze drying processes, including automatic determination of critical product data. AutoLyo Using pre-defined programs/recipes and intelligent interactions of product-related parameters such as • Product temperature • Ice condenser temperature • LyoRx (electrical resistance) • Pressure data (pressure increase test, comparison between Pirani and capacitive sensor) Pressure increase test (6 and 10 kg systems) The transition from the main drying phase to the final drying phase can be initiated with...

Process optimisation – innovative tools WTMplus in Martin Christ pilot units Wireless temperature measurement WTMplus for up to 16 sample sensors is available as an option. Special features include: • Fully integrated system within LSCplus controller • No separate modules necessary for monitoring and visualisation • Antenna inside drying chamber for maximum coverage of all vial positions • Improved sensor technology, compact and robust design • High accuracy ±0.5 K (max. ±1 K) • No heat input to samples as with wired probes, therefore measurement of real values • Excellent value for money LyoBalance...

Technical specifications Specifications One chamber 4 kg 3 kg/24 h approx. –55 °C approx. 41 l One chamber 4 kg 3 kg/24 h approx. –88 °C approx. 41 l Nominal power of basic unit Ice condenser: • Max. capacity • Max. performance • Temperature • Chamber volume Shelf system: • Dimensions (W x D) • Temperature range • Temperature accuracy Refrigeration system Refrigerant Dimensions (W x H x D) with stoppering device and manifold Weight Power supply (other voltages upon request) Defrosting function Vial stoppering: • Manual • Hydraulic • Automatic function "aeration-stoppering-storage" Process control...