Pleth Variability Index Pulse co-oximeter® PVI Pleth Variability Index (PVI®) is a breakthrough measurement that may help clinicians noninvasively and continuously assess fluid status of patients. Noninvasive > Continuous >> Fluid administration is critical to optimizing patient status.1 >> Traditional methods to guide fluid administration often fail to predict fluid responsiveness.2 >> Newer methods may accurately predict responsiveness but are invasive or costly.3 >> PVI has been shown to help clinicians predict fluid responsiveness in mechanically ventilated patients under general anesthesia during surgery and in the ICU.4, 5 >> PVI has been shown to help clinicians improve fluid management and decrease lactate levels compared to standard care.6 “PVI demonstrated high accuracy in discriminating fluid responders from non-responders—providing a unique opportunity to better manage a patient’s fluid volume to optimize cardiac performance and organ perfusion.” maxime cannesson, MD Associate Professor of Anesthesiology in the Department of Anesthesiology & Perioperative Care at the University of California, Irvine

CLINICAL BENEFITS Pleth Variability Index (PVI) Arterial Pulse Pressure (APP) Pulmonary Capillary Wedge Pressure (PCWP) Central Venous Pressure (CVP) Adapted from Cannesson M. et a I. Br J Anesth 2008;101(2):200-206. PVI showed a similar accuracy (0.93 area under the curve) vs. pulse pressure variation from an invasive arterial catheter (0.94) and superior accuracy vs. cardiac index (0.56), central venous pressure (0.42), and pulmonary capillary wedge pressure (0.40). PVI has been shown to help clinicians to predict fluid ventilated patients under general anesthesia, defined as a significant...