Total Hemoglobin pulse co-oximeter® SpHb Total Hemoglobin (SpHb®) is a breakthrough measurement that allows clinicians to noninvasively and continuously monitor hemoglobin— facilitating earlier and better clinical decisions, improved patient safety, and reduced cost of care. Noninvasive > Continuous surgery >> Blood transfusions increase morbidity, mortality, and cost of treatment.1, 2, 3, 4 >> Continuous and noninvasive SpHb is proven to help clinicians reduce blood transfusions during surgery.5 critical care and obstetrics >> Late detection of bleeding increases risks and cost of treatment.6 >> Continuous and noninvasive SpHb allows you to track changes in hemoglobin that may help you detect bleeding earlier.7 emergency department >> Traditional invasive lab testing provides delayed results and requires a painful needle stick and time consuming blood draws. >> Noninvasive spot check hemoglobin may facilitate timely patient assessment and reduce the need to wait for lab results. “ Masimo SpHb is an impressive new tool that could potentially help us to more safely guide patients in surgery through to recovery. With it, not only can we spot hemoglobin changes as they occur, but we can see where they are heading. This ability to identify an upward or downward hemoglobin trend on a second-by-second basis as it occurs could be of tremendous value.” Ronald Miller, MD Chief of Anesthesia, Professor and Chairman of the Dept. of Anesthesia and Perioperative Care at the University of California, San Francisco, CA

Clinical accuracy SpHb CO-Oximeter 16 SpHb (g/dL) 14 12 10 8 6 Bias + Standard Deviation = 0.0 + 1.0 g/dL 4 18 16 HemoCue Hb (g/dL) CO-Oximter Hb (g/dL) 16 HemoCue 18 14 12 10 8 6 6 8 10 12 14 16 18 14 12 10 8 6 4 2 Bias + Standard Deviation = 0.9 + 0.6 g/dL Bias + Standard Deviation = 0.3 + 1.3 g/dL 0 4 4 © 2012 M asimo C orporation. A ll rights reserved. 18 4 Hematology Analyzer tHb (g/dL) 6 8 10 12 14 16 18 4 6 8 10 12 14 16 18 Hematology Analyzer tHb (g/dL) Hematology Analyzer tHb (g/dL) >> In Masimo’s FDA submission, SpHb was validated in a range of 8 to 17 g/dL with accuracy of 1.0 g/dL...