Methemoglobin pulse co-oximeter® Methemoglobin (SpMet®) is a breakthrough measurement that allows clinicians to noninvasively and immediately detect elevated levels of methemoglobin in the blood— facilitating earlier diagnosis and treatment for patients with methemoglobinemia, a dangerous but underdiagnosed and undertreated condition. Noninvasive > Continuous >> Methemoglobinemia is an important clinical condition, more common than generally believed, and is linked to increased morbidity and mortality.1 >> Many procedures and drugs commonly used in clinical practice— including iNO therapy in neonates—have been documented as contributing to induced methemoglobinemia.1 >> Methemoglobinemia occurs across all care areas and patient populations yet is often unrecognized and misdiagnosed.1 Select drugs documented to contribute to Methemoglobinemia Benzocaine EMLA topical Nitric oxide Nitrous oxide Phenazopyridine (Pyridium) Silver Nitrate Sodium Nitrate “ Acquired Methemoglobinemia is fairly common and causes morbidity and mortality in both the inpatient and outpatient settings. Acquired methemoglobinemia is often unrecognized and thus untreated.” Dr. Rachel ash bernal and other researchers at Johns Hopkins Hospital

Clinical accuracy SpMet (%) from Pulse CO-Oximetry >> In comparisons of SpHb readings with invasive methemoglobin (MetHb) measurements taken at the same time and analyzed by a laboratory CO-Oximeter, SpMet was validated in the range of 1-15% with an accuracy of +1% at 1 standard deviation.* * Masimo FDA Submission Data © 2012 Masimo Corporation. All rights reserved. Proven accuracy compared to invasive laboratory methods* Reference MetHb (%) from Laboratory CO-Oximeter TECHNOLOGY PLATFORM Masimo rainbow SET® is a noninvasive monitoring platform enabling the assessment of multiple blood constituents...