Create and control hypoxic environments with one instrument. Gas Mixer.

Product catalog summary

Project Overview
The project, in collaboration with the University of Sydney, focuses on the relationship between Obstructive Sleep Apnea (OSA) and colorectal carcinoma cells. It is managed by Dr. Kristina M. Cook from the Charles Perkins Centre, who has a strong background in Chemical Biology.

Role of MCQ Instruments
MCQ Instruments are utilized to create and control specific hypoxic environments necessary for the research. Their Gas Blenders significantly reduce gas consumption by 30% and simplify both hardware and software setup, leading to a 70% time saving.

Research Significance
OSA is linked to increased cancer development and worse outcomes due to nocturnal intermittent hypoxia. The study uses animal models to show increased tumor growth and metastasis under OSA-like conditions. The research aims to understand how intermittent hypoxia affects HIF-1 activity, which is crucial in cancer progression.

Technological Advantages
The GB100 Series allows precise control of gas flow rates from 0.1 ml/min to 500 ml/min without cut-off, ensuring stable flow even at lower ranges. The Software PRO Version enables automation of experiments, enhancing research efficiency.

Research Findings
The study developed a cell-based model to examine intermittent hypoxia effects on HCT116 colorectal cancer cells. It was found that intermittent hypoxia increases HIF-1α and the expression of HIF-target genes, which are associated with a worse prognosis. The total dose of hypoxia, rather than the frequency or duration of cycles, determined the magnitude of changes in the hypoxic signature.

Conclusion
The use of MCQ Gas Mixers facilitates cancer research by simplifying equipment setup and allowing for customizable oxygen level protocols, thereby advancing the understanding of tumor hypoxia effects.

Catalog excerpts

Create and control hypoxic environments with one instrument. Gas Mixer.-1

© HYPOXIC ATMOSPHERE © LIFE SCIENCE © MEDICAL STUDIES A SOLID BUSINESS CASE IN COLLABORATION WITH THE “UNIVERSITY OF SYDNEY “ GENERAL INFORMATION ABOUT THE PROJECTTARGET OF THE PROJECT: Obstructive SLeep Apnea and CoLorectaL Carcinoma CeLLs DEPARTMENT: CharLes Perkins Centre HEAD OF PROJECT MANAGEMENT: Dr. Kristina M. Cook - kristina.cookcasydney.edu.au ROLE OF MCQ INSTRUMENTS: To create and control, specific hypoxic environments. MORE INFORMATION ABOUT THE HEAD OF THE PROJECT Dr Kristina Cook is a research fellow in the Charles Perkins Centre. Dr Cook completed her D.Phil. in Chemical Biology at the University of Oxford in a collaborative program with the NIH (USA) as an OxCam Biomedical Research Scholar. She graduated Summa Cum Laude from San Diego State University, with a B.S. in Molecular and Cellular Biology and a minor in Chemistry (awarded a ‘distinction’, the highest honour).

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Create and control hypoxic environments with one instrument. Gas Mixer.-2

DESCRIPTION OF THE APPLICATION AND THE TARGET Obstructive sleep apnea (OSA) aﬀects a signiﬁcant proportion of the population and is linked to increased rates of cancer development and a worse cancer outcome. OSA is characterized by nocturnal intermittent hypoxia and animal models of OSA-like intermittent hypoxia show increased tumor growth & metastasis. Advanced tumors typically have regions of chronic hypoxia, activating the transcription factor, HIF-1, which controls the expression of genes involved in cancer progression. Rapid intermittent hypoxia from OSA has been proposed to increase HIF-1...

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