EMBRYO CULTURE MAMMALIAN HEART DEV. HIGH-RANGE O2 VARIATION A SOLID BUSINESS CASE IN COLLABORATION WITH THE “TECHNICAL UNIVERSITY OF MUNICH“ GENERAL INFORMATION ABOUT THE PROJECT Investigation of Early Mammalian Heart Development Department of Internal Medicine I (Cardiology) HEAD OF PROJECT MANAGEMENT: Dr. Jessica Kornherr To supply the rotating incubator with a very small flow of a defined gas mixture, varying concentrations and automate the process MORE INFORMATION ABOUT THE HEAD OF THE PROJECT The Technical University of Munich (TUM) is one of Europe’s top universities. It is committed to excellence in research and teaching, interdisciplinary education and the active promotion of promising young scientists. The university also forges strong links with companies and scientific institutions across the world. TUM was one of the first universities in Germany to be named a University of Excellence. Moreover, TUM regularly ranks among the best European universities in internationa

DESCRIPTION OF THE APPLICATION AND THE TARGET The mammalian heart is one of the rst and most complex organs formed during embryogenesis. Highly specialized signaling programs are guiding cardiac progenitor cells towards their right position in the forming heart to ensure its proper function. However, dysregulation in these complex pathways during early development can lead to congenital heart defects. Thus, there is high demand in investigating the molecular and cellular processes leading to abnormal heart development for analyzing disease mechanisms and developing potential therapies. Murine...