Small Vessel Myograph System

Small Vessel Myograph system GREETINGS AND WELCOME TO OUR IS-05 SMALL VESSEL MYOGRAPH DEVICE CATALOGUE! WELCOME TO PRECISION IN VASCULAR RESEARCH EXPLORE UNRIVALED PERFORMANCE AND PRECISION Embark on a journey of precision and innovation as Each device showcased in this catalogue embodies we introduce you to our cutting-edge range of devic- the culmination of cutting-edge technology and years es designed to revolutionize vascular research. At MDE of expertise. Witness the seamless integration of inno- Ltd., we pride ourselves on pioneering advancements in vation and functionality, empowering...

Small Vessel Myograph system The history of capillary vessel myography dates back Vessels from various species, including transgenic to the late 19th century, when the scientific and med- models, and vascular beds can be examined in a varie- ical community showed increasing interest in better ty of pathological disease states. Vessels are dissected, understanding the vascular structures and blood flow cleaned, and then mounted onto a myograph under dynamics. Capillaries, as microscopic vessels between isometric techniques. Each vessel is then normalized to arteries and veins, play a crucial role...

Small Vessel Myograph system The simple design and easy-to-use set-up makes the IS-05 small vessel myograph device ideal for both physiological and pharmacological investigations. Only non-toxic materials used while ISO-05 equipment was manufactured to avoid artefact effects. The volume of the bath is 10 ml. Inlets and outlets are provided for water jacket and for bubbling. Multi-chamber myograph systems are the most commonly used as they can measure the contractility of several tissues simultaneously. THE SYSTEM SHOWS A UNIQUE MODULARITY WITH FEATURES: • The device can be easily and quickly...

Small Vessel Myograph system Small vessel wire myograph bath system Force measuring bridge amplifier Temperature measuring amplifier Workstation with data acquisition software 1. Force measuring bridge amplifier and temperature measuring amplifier 4. Double walled buffer reservoir 5. Circulating water bath 7. Workstation with data acquisition software

Small Vessel Myograph system Measuring bath (channel 1) 9. Water jacket inlet tap (channel 1) 2. Measuring bath (channel 2) 10. Water jacket outlet tap (channel 1) 3. Water jacket inlet 11. Carbogen pressure adjuster tap (channel 1) 4. Bath unit overflow outlet (channel 1) 12. Water jacket bypass tap (channel 2) 13. Water jacket outlet tap (channel 2) 6. Bath unit overflow outlet (channel 2) 14. Water jacket inlet tap (channel 2) 7. Water jacket outlet 15. Carbogen pressure adjuster tap (channel 2) 8. Water jacket bypass tap (channel 1) Built in force measuring sensor 2. Sensor fastener 3. Sample...

Small Vessel Myograph system MAIN PARTS OF THE DEVICE Due to its modular design, assembling the device is re- Establish the electronic connections by linking the IN sock- markably straightforward, achievable in just a few steps. et (1) of the amplifier (A) to the 9-pole D-sub socket of Begin by addressing the electronic connections initial- the sensor (B) using extension cable (C). Notably, the sen- ly, and once completed, proceed to finalize the device’s sor is integrated into the bath. The extension cable (C) is integration with the tubes. The latter step is notably un- equipped with a 9-pole...

Small Vessel Myograph system The following diagram illustrates the tubing connections and outlines the theoretical configuration of the primary components. The tubing is pre-assembled onto the bath during the workshop phase, requiring only the connections between the main parts to be established. Given the uncertainty regarding the final setup location, factory standard length tubes have been affixed to the system, with the flexibility to be adjusted by shortening or elongating as needed. The water-heated capillary vessel myograph bath excels in efficiency, precision, and benefits compared to...

Small Vessel Myograph system Circulating water bath 2. Myograpph bath unit 3. Double walled Krebs reservoir Carbogen tank Buffer resevoir Reservoir holder clamp with bubling adjuster D Circulating water bath (CWB) E Baseplate F Myograph bath F1 Myograph bath buffer filling inlet 2. Water jacket inlet 3. F1 Myograph bath overflow outlet 4. F1 Myograph bath carbogen inlet 5. G1 Myograph bath carbogen inlet 8. Water jacket outlet 7. G1 Myograph bath overflow outlet 6. G1 Myograph bath buffer filling inlet

Small Vessel Myograph system One of the key attributes of the bath lies in its detachability and The detachability also facilitates easy maintenance, clean- reattachability to and from the base plate. This enables easy ing, and reconfiguration of the system, providing research- placement under a microscope, facilitating straightforward ers with enhanced accessibility and adaptability for diverse observation. Consequently, the microvessel can be effortlessly experimental setups. The ability to remove the bath from the secured to the holders, streamlining the experimental process baseplate streamlines...

Small Vessel Myograph system CHI bath is closed and ready to detachTAP UNIT In order to facilitate easy disconnection and reconnection, the baseplate is equipped with a tap system, allowing the detachment of the measurement baths from the water heating circuit without causing water used for heating to escape from the system. The purpose of the built-in tap units on the baseplate is to ensure that the water jacket circuit remains open even when one or both baths are detached from the baseplate. During the “Bath Off” mode, this tap combination enables the user to detach the bath for sample application...

Small Vessel Myograph system A BRAND NEW CLAMPING MECHANISM… Buffer reservoir In response to customer demands and the ongoing evolution of our systems, a cutting-edge clamp- ing mechanism (designated as unit 10) was introduced to our vessel myography baths in early 2022. The purpose of the clamping unit (1) is to accommodate and precisely position a diverse array of sensors and oth- er devices from MDE and various manufacturers, meeting the requirements of modern experimentation. To affix a sensor or other device within the clamp (1), begin by gently loosening the securing screws (3). This action...