CellColt Brochure
CellColt Brochure
The CellColt™ system is a selective multi-radial bone marrow aspiration device designed for stem cell therapy. It is developed by M.D.L. S.r.l., located in Delebio, Italy. The system is intended to enhance the recovery of stem cells and progenitor cells while minimizing contamination from peripheral blood.
System Features
- The device includes a patented lateral hole system that ensures homogeneous aspiration by varying the diameter of the side holes.
- A shorter cannula is used to increase stability during insertion and reduce aspirate coagulation.
- The system does not use a threaded handle, which minimizes movement and increases the overall length.
- A slider with a one-click system and sized side holes ensures uniform absorption along the tip's length.
- The diamond trocar tip provides stability during insertion into the cortical bone, and a blunt stylet ensures safe insertion into the marrow.
- A stopper is included to identify the minimum depth of insertion, and the system is designed for use without a centrifuge.
Bone Marrow Aspiration
The optimal site for bone marrow aspiration is the Iliac Crest, which has a higher concentration of cells compared to other sites like the tibia, heel, or femur. The CellColt™ system is designed to achieve selective aspiration, maximizing the recovery of stem and progenitor cells while minimizing peripheral blood contamination.
References
The document cites several studies and reviews that support the use of bone marrow aspirate concentrate in various clinical applications, particularly in orthopedics and tendon pathology.
Catalog excerpts
Sources 1. Cotter, EJ, Wang, KC, Yanke, AB, Chubinskaya, S (2018) Bone marrow aspirate concentrate for cartilage defects of the knee: From bench to bedside evidence. Cartilage, 9(2):161-170. 2. Imam, MA, Holton, J, Horriat, S, Negida, AS, Grubhofer, F, Gupta, R, Narvani, A, Snow, M (2017) A systematic review of the concept and clinical applications of bone marrow aspirate concentrate in tendon pathology. SICOT J, 3(58). 3. Nancarrow-Lei, R, Mafi, P, Mafi, R, Khan, W (2017) A systemic review of adult mesenchymal stem cell sources and their multilineage differentiation potential relevant to muskuloskeletal tissue repair and regeneration. Current stem cell research & therapy, 12(8), 601-610. 4. Scarpone, MA, Kuebler, D (2016) Maxx - regen bone marrow aspiration system and related concentrations of stem and progenitor cells. Royal Biologics. For device instructions or more information, contact us or visit our website CellColt™ Selective multiradial bone marrow aspiration system for stem cell therapy M.D.L. S.r.l. Via Tavani 1/A, Delebio (SO), Italy, 23014 Tel: +39 0342 682130 E-mail: [email protected]
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The best site for bone marrow aspiration is the Iliac Crest which contains a higher average concentration of cells compared to the tibia, heel or femur1, 2. Scarpone et al4 reports that, in order to limit the dilution with peripheral blood, the best trocar needs to have a closed tip in and radial side holes, which allow a more selective aspiration and in proximity to the trabeculae, where the higher concentrations of mesenchymal and progenitor cells are located. The CellColt™ System allow to achieve a selective aspiration of the bone marrow maximizing the stem cells and progenitor cells recovery...
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