MEASURE THE ANS TITRATE ANALGESICS IMPROVE POSTOPERATIVE PAIN ANI and NIPE in OR Analgesia Nociception Index New born Infant Parasympathetic Evaluation

The problem Pain is the conscious perception of nociception Nociception (from Latin nocere ‘to harm or hurt’) is the process Arreflexia activity muscle into of the sensory nervous system response to certain harmful or potentially harmful stimuli. In nociception, intense chemical Nociception triggers a variety of physiological changes and nociceptors, produces a signal that travels along a chain of nerve fibres via the spinal cord to the brain. (chili powder in the eyes), mechanical (cutting, crushing.), or thermal (heat and cold) stimulation of sensory nerve cells, called to control the autonomic...

In order to control surgical stress analgesics, often opioids, are administered, but overdosing and infra-dosing can cause side effects such as: longer recovery times (12), PONV (13), urine retention (14), shivering (15), thromboembolism (16), pulmonary complications (17), bradycardia (18), hypotension (19), ileum (14), respiratory failures (14), post-op hyperalgesia (15), delirium (16) (17), POCD (18), cancer progression (18) and chronic pain (19). By using ANI and NIPE monitors MDoloris offers insights into the sympathetic/parasympathetic balance allowing titration of analgesics (24) and the...

The result Analgesics are titrated based on heart rate and blood pressure. Funcke et al., demonstrated that ANI is more sensible and specific than haemodynamics to detect nociception in adults (9) and children (10). NIPE is able to show the effect of the analgesic provided and detect nociception better than heart rate (11). ANI/NIPE has been recommended with a B level by The Society for Pediatric Anesthesia in their recommendations for the use of opioids in children during the preoperative period (11). Detect nociception in adults 100 Possibility to decrease opioids administration whitout any...

Testimonials I use daily the ANI monitor during my opioid-free anesthesia to titrate the non-opioid analgesic drugs. It allows me to reduce the dexmedetomidine and lidocaine dosages, which results in a faster and better awakening process of the patient as hemodynamics do not always reflect the surgical stress of the patient. Dr. Jan Paul J Mulier MD Department of Anaesthesiology & Intensive care, AZ Sint-Jan Brugge KULeuven & UGent NIPE is an excellent intraoperative tool for pediatric anesthesiologists who assist neonates and infants. NIPE device allow us not only to confirm the efficacy of...

Improve outcomes: Published evidences: Intraoperative «Analgesia Nociception Index» - Guided Fentanyl Administration During Sevoflurane Anesthesia in Lumbar Discectomy and Laminectomy: A Randomized Clinical Trial 1,3 less NRS in PACU 64% lower PACU tot fentanyl 82% lower nausea / 23% shivering Henry D Upton1 , Guy L Ludbrook, Andrew Wing, Jamie W Sleigh Evaluation of the variability of ani values in digestive surgery Nguyen Quoc Kinh, Trinh Ke Diep, Emmanuel Boselli, Luu Quang Thuy Analgesia nociception index (ani) monitoring in patients with thoracic paravertebral block: a randomized controlled...

MDoloris Medical Systems SAS Biocentre Fleming - Bâtiment C Epi de Soil 270, rue Salvador Allende 59120 Loos - France Tel: +33 (0)3 62 09 20 80 / Fax +33 (0)9 72 38 75 27 www.mdoloris.com ANI Monitor V2, ANI MOC-9, NIPE Monitor V1 and the ANI-MR are class IIa medical device, manufactured by MDoloris Medical Systems. CE evaluation was performed by Bureau Veritas Italy (1370) for the ANI Monitor V2, NIPE Monitor V1 and the ANI MOC-9. CE evaluation was performed by BSI (2797) for the ANI-MR.© 2021 MDoloris Medical Systems. All rights reserved. MD/QUA/EN14.3 v.04